Iron-crosslinked Rososome with robust stability and high drug loading for synergistic cancer therapy

Xue, Xiangdong; Ricci, Marina; Qu, Haijing; Lindstrom, Aaron; Zhang, Dalin; Wu, Hao; Lin, Tzu Yin; Li, Yuanpei

doi:10.1016/j.jconrel.2020.10.013

Cited by 11 publications

(8 citation statements)

References 60 publications

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“…The ironcatechol coordination was also employed to build crosslinked hydrogel with better strength, stiffness, toughness, and selfhealing abilities. [46] Two adjacent Se moieties can form diselenide bonds, making Se metals a good choice for constructing SCN. As shown in Figure 6B, Park group [47] developed a diselenide-crosslinked polymeric micelle for DOX delivery to treat prostate cancer.…”

Section:  Built-in Scns Constructed By Metal-based Crosslinking Str...mentioning

confidence: 99%

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Stimuli‐responsive crosslinked nanomedicine for cancer treatment

Xue

2022

Exploration

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Nanomedicines are attractive paradigms to deliver drugs, contrast agents, immunomodulators, and gene editors for cancer therapy and diagnosis. However, the currently developed nanomedicine suffers from poor serum stability, premature drug release, and lack of responsiveness. Crosslinking strategy can be utilized to overcome these shortcomings by employing stimuli‐responsive chemical bonds to tightly hold the nanostructure and releasing the payloads spatiotemporally in a highly controlled manner. In this Review, we summarize the recently ingenious design of the stimuli‐responsive crosslinked nanomedicines (SCN) in the field of cancer treatment and their advances in circumventing the drawbacks of the conventional drug delivery system. We classify the SCNs into three categories based on the crosslinking strategies, including built‐in, on‐surface, and inter‐particle crosslinking nanomedicines. Thanks to the stimuli‐responsive crosslinkages, SCNs are capable of keeping robust stability during systemic circulation. They also respond to the particular tumoral conditions to experience a series of dynamic changes, such as the changes in size, surface charge, targeting moieties, integrity, and imaging signals. These characteristics allow them to efficiently overcome different biological barriers and substantially improve the drug delivery efficiency, tumor‐targeting ability, and imaging sensitivities. With the examples discussed, we envision that our perspectives can inspire more attempts to engineer intelligent nanomedicine to achieve effective cancer therapy and diagnosis.

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Section:  Built-in Scns Constructed By Metal-based Crosslinking Str...mentioning

confidence: 99%

Section: Built‐in Crosslinking Strategymentioning

confidence: 99%

Stimuli‐responsive crosslinked nanomedicine for cancer treatment

Xue

2022

Exploration

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“…RA is encapsulated in a hydrophobic bilayer that enhances bioavailability when exposed to the gastrointestinal tract. Xue et al developed iron-crosslinked RA–lipid conjugates with high contents of RA and doxorubicin (DOX), which had better stability, bioavailability, and synergistic anti-breast cancer efficacy [ 68 ]. RA–phospholipid complexes increased oral bioavailability through enhanced intestinal permeability; an in vitro assessment determined that it had better permeation and antioxidant activity [ 69 ].…”

Section: Improvement Of Bioaccessibility and Bioavailability—novel Te...mentioning

confidence: 99%

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer

Zhao

Jin

et al. 2022

Biomolecules

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Cancer constitutes a severe threat to human health and quality of life and is one of the most significant causes of morbidity and mortality worldwide. Natural dietary products have drawn substantial attention in cancer treatment and prevention due to their availability and absence of toxicity. Rosmarinic acid (RA) is known for its excellent antioxidant properties and is safe and effective in preventing and inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, and anti-tumor applications of RA-enriched dietary supplements. We discuss techniques to improve RA bioavailability and provide a mechanistic discussion of RA regarding tumor prevention, treatment, and adjuvant therapy. RA exhibits anticancer activity by regulating oxidative stress, chronic inflammation, cell cycle, apoptosis, and metastasis. These data suggest that daily use of RA-enriched dietary supplements can contribute to tumor prevention and treatment. RA has the potential for application in anti-tumor drug development.

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“…They have added ferric iron to the RS for cross linking to stabilize the liposomal structure. The in vivo experiments were conducted in tumor bearing breast cancer mice, which demonstrated that the iron cross linked RS showed significant activity for cancer therapy [83].…”

Section: Liposomesmentioning

confidence: 99%

Journey of Rosmarinic Acid as Biomedicine to Nano-Biomedicine for Treating Cancer: Current Strategies and Future Perspectives

et al. 2022

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Rosmarinic acid (RA) is a polyphenolic metabolite found in various culinary, dietary sources, and medicinal plants like Coleus scutellarioides (Linn) Benth., Lavandula angustifolia Linn., Mellisa officinalis Linn., Origanum vulgare Linn., Rosmarinus officinalis Linn., Zataria multiflora Boiss. and Zhumeria majdae Rech. F. Apart from its dietary and therapeutic values, RA is an important anticancer phytochemical owing to its multi-targeting anticancer mechanism. These properties provide a scope for RA’s therapeutic uses beyond its traditional use as a dietary source. However, its oral bioavailability is limited due to its poor solubility and permeability. This impedes its efficacy in treating cancer. Indeed, in recent years, tremendous efforts have been put towards the development of nanoformulations of RA for treating cancer. However, this research is in its initial stage as bringing a nanoparticle into the market itself is associated with many issues such as stability, toxicity, and scale-up issues. Considering these pitfalls during formulation development and overcoming them would surely provide a new face to RA as a nanomedicine to treat cancer. A literature search was conducted to systematically review the various biological sources, extraction techniques, and anticancer mechanisms through which RA showed multiple therapeutic effects. Various nanocarriers of RA pertaining to its anticancer activity are also discussed in this review.

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Iron-crosslinked Rososome with robust stability and high drug loading for synergistic cancer therapy

Cited by 11 publications

References 60 publications

Stimuli‐responsive crosslinked nanomedicine for cancer treatment

Stimuli‐responsive crosslinked nanomedicine for cancer treatment

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer

Journey of Rosmarinic Acid as Biomedicine to Nano-Biomedicine for Treating Cancer: Current Strategies and Future Perspectives

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