1980
DOI: 10.1002/1097-0142(19800801)46:3<565::aid-cncr2820460324>3.0.co;2-n
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Iron, copper, and zinc liver tissue levels in patients with malignant lymphomas

Abstract: Levels of iron, copper, and zinc in liver tissue and of copper in serum were studied in 53 cases of untreated malignant lymphoma (14 cases of Hodgkin's disease and 17 of lymphocytic and 22 of histiocytic lymphoma). The values were compared with the levels of these metals in the liver tissue of 23 healthy persons. Liver tissue was obtained by means of percutaneous biopsy examination with a Menghini needle. Part of the samples was used for histologic examination, and the remainder for metal level determination. … Show more

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Cited by 20 publications
(8 citation statements)
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“…The fact that copper levels, both in serum and tissue, are elevated in various malignancies has been known for several decades [1,2,4]. There is a considerable body of evidence to indicate that copper is required for tumour angiogenesis [30].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The fact that copper levels, both in serum and tissue, are elevated in various malignancies has been known for several decades [1,2,4]. There is a considerable body of evidence to indicate that copper is required for tumour angiogenesis [30].…”
Section: Discussionmentioning
confidence: 99%
“…Elevation of copper levels in the serum and blood of patients with malignancies is well documented [1][2][3][4]. Studies with plant-derived polyphenols such as epigallocatechin-3-gallate (EGCG) [5,6] show that they are potent inducers of apoptosis in malignant cells, whereas normal cells are refractory to this effect.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, zinc concentration in normal tissues surrounding the secondary liver cancers was statistically higher than normal controls. Hence, differences in Zn concentration may cause some health problems [23,24].…”
Section: Livermentioning
confidence: 99%
“…It may be mentioned that chromatin bound copper can be mobilized by copper chelators such as 1,10-phenanthroline to cause internucleosomal DNA fragmentation [23]. It is well evidenced that serum and tissue copper levels are considerably elevated in cancer patients [24][25][26][27]. Such a mechanism would be independent of receptor and mitochondria mediated programmed cell death [3,28].…”
Section: Introductionmentioning
confidence: 99%