Iron catalyzed conversion of NO into nitrosonium (NO+) and nitroxyl (HNO/NO−) species

Stojanovic, Srdjan; Stanić, Dragana; Nikolić, Milan; Spasić, Mihajlo; Niketić, Vesna

doi:10.1016/j.niox.2004.09.007

Cited by 53 publications

(25 citation statements)

References 37 publications

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“…As regards our hypothetical {Fe(NO) 2 } 7 structure of M-DNIC, the formation of the [Fe + (NO + ) 2 ] core in M-DNIC can be easily explained in the framework of the mechanism depicted in Scheme 1. The concomitant formation of nitrous oxide (N 2 O) in the course of M-DNIC synthesis and the involvement of three NO molecules in the formation of one M-DNIC were confirmed in experiments carried out by other authors [45, 46]. …”

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confidence: 54%

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Electronic and Spatial Structures of Water-Soluble Dinitrosyl Iron Complexes with Thiol-Containing Ligands Underlying Their Ability to Act as Nitric Oxide and Nitrosonium Ion Donors

Vanin

Burbaev

2011

Journal of Biophysics

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The ability of mononuclear dinitrosyl iron commplexes (M-DNICs) with thiolate ligands to act as NO donors and to trigger S-nitrosation of thiols can be explain only in the paradigm of the model of the [Fe+(NO+)2] core ({Fe(NO)2}7 according to the Enemark-Feltham classification). Similarly, the {(RS−)2Fe+(NO+)2}+ structure describing the distribution of unpaired electron density in M-DNIC corresponds to the low-spin (S = 1/2) state with a d7 electron configuration of the iron atom and predominant localization of the unpaired electron on MO(dz2) and the square planar structure of M-DNIC. On the other side, the formation of molecular orbitals of M-DNIC including orbitals of the iron atom, thiolate and nitrosyl ligands results in a transfer of electron density from sulfur atoms to the iron atom and nitrosyl ligands. Under these conditions, the positive charge on the nitrosyl ligands diminishes appreciably, the interaction of the ligands with hydroxyl ions or with thiols slows down and the hydrolysis of nitrosyl ligands and the S-nitrosating effect of the latter are not manifested. Most probably, the S-nitrosating effect of nitrosyl ligands is a result of weak binding of thiolate ligands to the iron atom under conditions favoring destabilization of M-DNIC.

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supporting

confidence: 54%

“…(For the presence in DNIC of only two thiol-containing ligands see below). The concomitant formation of nitrous oxide (N 2 O) in the course of M-DNIC synthesis and the involvement of three NO molecules in the formation of one M-DNIC were confirmed in more recent studies [45, 46]. …”

mentioning

confidence: 64%

Electronic and Spatial Structures of Water-Soluble Dinitrosyl Iron Complexes with Thiol-Containing Ligands Underlying Their Ability to Act as Nitric Oxide and Nitrosonium Ion Donors

Vanin

Burbaev

2011

Journal of Biophysics

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“…For example, nitric oxide ( ∙ NO) was initially thought to interact directly with GSH to produce S -nitrosoglutathione (GSNO). However, further investigation demonstrated ∙ NO must first be converted to NO + (nitrosonium ion) in an iron- or copper-catalyzed reaction before reacting with GSH to form GSNO [90, 91]. It should be noted that GSNO and other nitrosothiols can be used for storage and transportation of ∙ NO because as unstable compounds they can be decomposed easily to generate ∙ NO and GSSG.…”

Section: Glutathione Functionsmentioning

confidence: 99%

Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

Lushchak

2012

Journal of Amino Acids

957

741

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Glutathione (GSH) is a tripeptide, which has many biological roles including protection against reactive oxygen and nitrogen species. The primary goal of this paper is to characterize the principal mechanisms of the protective role of GSH against reactive species and electrophiles. The ancillary goals are to provide up-to-date knowledge of GSH biosynthesis, hydrolysis, and utilization; intracellular compartmentalization and interorgan transfer; elimination of endogenously produced toxicants; involvement in metal homeostasis; glutathione-related enzymes and their regulation; glutathionylation of sulfhydryls. Individual sections are devoted to the relationships between GSH homeostasis and pathologies as well as to developed research tools and pharmacological approaches to manipulating GSH levels. Special attention is paid to compounds mainly of a natural origin (phytochemicals) which affect GSH-related processes. The paper provides starting points for development of novel tools and provides a hypothesis for investigation of the physiology and biochemistry of glutathione with a focus on human and animal health.

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“…Oxidation of the Fe center produces Fe(III)-NO compounds which can transfer NO + easily while being reduced to Fe(II). If a suitable oxidant (even a slow one) is present, the iron can sustain a catalytic cycle [65] (Scheme 6).…”

Section: Nitrosationmentioning

confidence: 99%

Redox signaling: Bioinorganic chemistry at its best

Ullrich

Kissner

2006

Journal of Inorganic Biochemistry

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Iron catalyzed conversion of NO into nitrosonium (NO+) and nitroxyl (HNO/NO−) species

Cited by 53 publications

References 37 publications

Electronic and Spatial Structures of Water-Soluble Dinitrosyl Iron Complexes with Thiol-Containing Ligands Underlying Their Ability to Act as Nitric Oxide and Nitrosonium Ion Donors

Electronic and Spatial Structures of Water-Soluble Dinitrosyl Iron Complexes with Thiol-Containing Ligands Underlying Their Ability to Act as Nitric Oxide and Nitrosonium Ion Donors

Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

Redox signaling: Bioinorganic chemistry at its best

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