Iron and folate metabolism in tuberculosis.

Roberts, P. D.; Av, Hoffbrand; Mollin, D. L.

doi:10.1136/bmj.2.5507.198

Cited by 40 publications

(17 citation statements)

References 20 publications

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“…A number of studies have documented anemia in patients with TB (3, 5, 8-11), however, these studies involved only small numbers of patients and the results were not uniform. Moreover, there has been no study on the evolution of TB-associated anemia after establishment of short-term combination anti-TB chemotherapy in the 1980s.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence and Evolution of Anemia Associated with Tuberculosis

et al. 2006

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Tuberculosis (TB) may produce abnormalities in the peripheral blood, including anemia. However, the evolution of TB-associated anemia with short-term combination anti-TB chemotherapy has not been well elucidated. The aim of this study was to characterize TB-associated anemia by clarifying its prevalence, characteristics, and evolution, through involving large numbers of patients with TB. The medical records of adult patients with TB diagnosed between June 2000 and May 2001 were reviewed. Among 880 patients with TB, 281 (31.9%) had anemia on diagnosis of TB, however, the hemoglobin concentration was less than 10 g/dL in only 45 patients (5.0%). Anemia was more frequently associated with the female and old age. Good treatment response, young age (≤65 yr-old) and initial high hemoglobin were the predictive factor for resolution of anemia. In 202 patients with anemia (71.9%), anemia was normocytic and normochromic. During or after anti-TB treatment, anemia was resolved in 175 (64.6%) out of 271 patients without iron intake. The mean duration of resolution from the initiation of anti-TB treatment was 118.8±113.2 days. In conclusion, anemia is a common hematological abnormality in patients with TB and close observation is sufficient for patients with TB-associated anemia, because TB-associated anemia is usually mild and resolves with anti-TB treatment.

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Section: Introductionmentioning

confidence: 99%

The Prevalence and Evolution of Anemia Associated with Tuberculosis

et al. 2006

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“…The association of folate deficiency and tuberculosis has been noted by Roberts et al (1966). They concluded that folate deficiency was not due to the chemotherapy but to the disease process itself, or a poor diet.…”

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confidence: 99%

Lactobacillus casei C.S.F. folate activity.

Wells¹,

Casey²

1967

BMJ

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“…The most common hematologic abnormality that is associated with TB is cytopenia. In another study of 68 patients taking PAS, approximately 90% had subnormal blood folic acid levels, in contrast to 35% of a control group of similar patients (Roberts et al 1966). As with any chronic infection, there may be a suppression of normal hematopoiesis.…”

Section: Possible Mechanisms Of Hematologic Findings In Tuberculosismentioning

confidence: 92%

Hematologic Findings in Mycobacterial Infections Among Immunosuppressed and Immunocompetent Patients

Akpek

2004

Tuberculosis

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Iron and folate metabolism in tuberculosis.

Cited by 40 publications

References 20 publications

The Prevalence and Evolution of Anemia Associated with Tuberculosis

The Prevalence and Evolution of Anemia Associated with Tuberculosis

Lactobacillus casei C.S.F. folate activity.

Hematologic Findings in Mycobacterial Infections Among Immunosuppressed and Immunocompetent Patients

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