Iritectol G, a novel iridal-type triterpenoid from Iris tectorum displays anti-epileptic activity in vitro through inhibition of sodium channels

Zhang, Chunlei; Chen, Juan; Zhao, Fang; Chen, Ruo-Yun; Yu, De‐Quan; Cao, Zhengyu

doi:10.1016/j.fitote.2017.08.003

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…Both geometrical isomers viz. , iritectols C ( 28 ) 11 and G ( 29 ) 21 (Fig. 3), include the tetrahydrofuran moiety between C-16/C-19 in the polyene side chain, and are produced by Iris tectorum .…”

Section: Iridal Triterpenesmentioning

confidence: 99%

“…On the other hand, it also possessed moderate effects towards ovarian cancer (A2780: IC 50 : 6.5 μM), colon cancer (HCT-16: IC 50 : 9.7 μM), and lung cancer (NCI-H1650: IC 50 : 9.8 μM). 21 Additionally, iritectol G ( 29 ) illustrated anti-epileptic effects via inhibiting spontaneous (IC 50 : 8.2 μM) and 4-aminopyridine-evoked calcium oscillations (IC 50 : 12.5 μM). 21…”

Section: Iridal Triterpenesmentioning

confidence: 99%

“…21 Additionally, iritectol G ( 29 ) illustrated anti-epileptic effects via inhibiting spontaneous (IC 50 : 8.2 μM) and 4-aminopyridine-evoked calcium oscillations (IC 50 : 12.5 μM). 21…”

Section: Iridal Triterpenesmentioning

confidence: 99%

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Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis

et al. 2023

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Section: Iridal Triterpenesmentioning

confidence: 99%

Section: Iridal Triterpenesmentioning

confidence: 99%

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Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis

et al. 2023

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“…Previous chemical investigations have indicated that I. tectorum Maxim. contains a range of compounds including isoflavones, 2 C ‐glycosylflavone, 3 iridal‐type triterpenoids, 4–10 lignans 11 and apocynin derivatives 12 . In addition, an HPLC‐DAD/ESI‐MS n analysis used both positive and negative ion modes to identify fourteen known flavonoids and three phenolic acids in the rhizome of I. tectorum 13 .…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of the chemical components of Iris tectorum Maxim. and evaluation of their nitric oxide inhibitory activity

Gao

Zhang

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Iris tectorum Maxim. is a traditional medicinal herb that is commonly used to treat inflammatory conditions. The present study investigated the fragmentation patterns of isoflavone glycosides and their qualitative analysis. In addition, lipopolysaccharide (LPS)‐induced RAW264.7 macrophages were used to evaluate the anti‐inflammatory properties of I. tectorum Maxim. samples collected at different time points during the year. Methods High‐performance liquid chromatography/quadrupole time‐of‐flight tandem mass spectrometry (HPLC/QTOF‐MS/MS) and HPLC with diode‐array detection were employed for qualitative and quantitative analysis. The fragmentation patterns of the isoflavones were observed in negative electrospray ionization mode with collision‐induced dissociation (CID). Their anti‐inflammatory activity was assessed via nitric oxide (NO) production in LPS‐treated RAW264.7 macrophages. Results A total of 15 chemical components were observed and tentatively identified using HPLC/QTOF‐MS/MS. At low collision energy, the relative abundances of the aglycone radical anions Y0−, [Y0 − H]−•, [Y0 − CH3]−• and [Y0 − H− CH2]−• were used for the structural characterization of tectoridin and tectorigenin‐4′‐O‐β‐D‐glucoside. The radical ions [Y0 − CH3]−• and [Y0 − H − 2CH3]−• were also employed to differentiate between iristectorin A and iristectorin B based upon their high‐energy CID spectra. Levels of 9.02 mg/g of tectoridin and 1.04 mg/g of tectorigenin were found in samples collected in June, which exhibited 69.7% NO inhibitory activity. Conclusions The characteristic fragmentation patterns enabled us to reliably identify isoflavone glycosides. The results of the quantitative determination and NO inhibitory activity offer insight into the optimal I. tectorum Maxim. harvesting time.

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Rearranged iridal-type triterpenoids from Iris tectorum

et al. 2019

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Iritectol G, a novel iridal-type triterpenoid from Iris tectorum displays anti-epileptic activity in vitro through inhibition of sodium channels

Cited by 7 publications

References 32 publications

Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis

Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis

Identification and characterization of the chemical components of Iris tectorum Maxim. and evaluation of their nitric oxide inhibitory activity

Rearranged iridal-type triterpenoids from Iris tectorum

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