Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Zhang, Huijie; Zhang, Xianfeng; Ma, Zufu; Pan, Lingling; Chen, Zheng; Han, Hao; Han, Chao; Zhuang, Xiongjie; Lü, Yan; Li, Xuejun; Yang, Shuyu; Li, Xiaoying

doi:10.1016/j.jhep.2013.04.030

Cited by 195 publications

(174 citation statements)

References 33 publications

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“…The significant lowest levels of triglycerides and downtrend in VLDL in HIG observed in the present study corroborate with other study (30), which observed that higher levels of lipids in blood and liver have correlation with lower FNDC5/irisin levels.…”

Section: Discussionsupporting

confidence: 93%

Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk

Bonfante

Chacon-Mikahil

Brunelli

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Thus, the aim of this study was to compare if higher or smaller fibronectin type 3 domain-containing protein 5 (FNDC5)/irisin levels are associated with inflammatory and metabolic markers, caloric/macronutrient intake, physical fitness and type 2 diabetes mellitus (T2DM) risk in obese middle-aged men, and also to correlate all variables analyzed with FNDC5/irisin. Subjects and methods: On the basis of a cluster study, middle-aged obese men (IMC: 31.01 ± 1.64 kg/m²) were divided into groups of higher and smaller levels of FNDC5/irisin. The levels of leptin, resistin, adiponectin, tumor necrosis factor alpha (TNFα), interleukin 6 and 10 (IL6, IL10), lipopolysaccharide (LPS), glucose, insulin, glycated hemoglobin, insulin resistance and sensibility, lipid profile, risk of T2DM development, body composition, rest energy expenditure, caloric/macronutrient intake and physical fitness were measured. Results: The higher FNDC5/ irisin group presented improved insulin sensibility (homeostasis model assessment -sensibility (HOMA-S) (p = 0.01) and QUICKI index (p < 0.01)), insulin (p = 0.02) and triglyceride levels (p = 0.01), lower insulin resistance (homeostasis model assessment -insulin resistance (HOMA-IR) (p = 0.01), triglycerides/glucose (TYG index) (p = 0.02), neck circumference (p = 0.02), risk of T2DM development (p = 0.02), tendency to decrease serum resistin (p = 0.08) and significant lower LPS levels (p = 0.02). Inverse correlations between FNDC5/irisin and body weight (r -0.46, p = 0.04), neck circumference (r -0.51, p = 0.02), free fat mass (r -0.49, p = 0.02), triglycerides (r -0.43, p = 0.05) and risk of developing T2DM (r -0.61, p = 0.04) were observed. Conclusions: These results suggest that higher FNDC5/irisin levels in obese middle-aged men are related to a better metabolic profile and lower risk of T2DM development and serum LPS, a potential inducer of insulin resistance. Arch Endocrinol Metab. 2017;61(6):524-33

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Section: Discussionsupporting

confidence: 93%

Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk

Bonfante

Chacon-Mikahil

Brunelli

et al. 2017

Arch. Endocrinol. Metab.

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“…A limitation of the current study and previous is that a wide range of circulating irisin levels have been reported (Choi et al, 2013;Huh et al, 2012;Moreno-Navarrete et al, 2013;Stengel et al, 2012;Zhang et al, 2013), even through a same study (Moreno-Navarrete et al, 2013). This range of detection could be the result of variations on target epitopes among manufacturers, as no consensus exists on which part or parts of this membrane protein are soluble, nor does a consensus on the mechanism of irisin secretion exist (Roca-Rivada et al, 2013).…”

Section: Discusionmentioning

confidence: 73%

“…Surprisingly, a recent report has revealed a significant decrease in circulating irisin and adipose and muscle tissue gene expression levels in obesity, suggesting that irisin is inversely associated with different adiposity markers (Moreno-Navarrete et al, 2013). On the other hand, low circulating irisin levels were associated with chronic kidney disease (Wen et al, 2013), intrahepatic triglycerides content in obese adults with non alcoholic fatty liver disease (Zhang et al, 2013) and with type 2 diabetes (Choi et al, 2013;Liu et al, 2013). All together these reports highlight the need of further research to elucidate the true role of irisin in health and disease (Polyzos et al, 2013).…”

Section: Discusionmentioning

confidence: 95%

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

124

114

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Objective: The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. The objective of this work was to evaluate whether circulating human irisin levels are modulated by body size and changes in adiposity during an energy restriction treatment and the subsequent weight regain.Methods: A group of 94 obese patients (50 men, 44 women; 49.4 6 9.4 years; BMI 35.6 6 4.5 kg/m 2 ) participated in a weight loss program following an 8-week hypocaloric diet (230% energy expenditure) with a weight maintenance follow-up. The patients were evaluated at 0, 8, and 24 weeks after starting treatment. In addition, 48 normal-weight subjects (16 men, 32 women; 35.71 6 8.8 years; BMI 22.9 6 2.2 kg/m 2 ) participated as controls. Plasma irisin, body weight, body composition, and hormones controlling energy homeostasis were measured.Results: Irisin levels were higher in obese subjects (353.1 6 18.6 ng/mL) than in those of normal-weight (198.4 6 7.8 ng/mL; P 0.001) and were also higher in men (340.9 6 20 ng/mL) than in women (267.6 6 12 ng/mL; P < 0.05). Moreover, irisin plasma levels were significantly correlated with high levels of direct and indirect adiposity markers, such as weight, BMI, waist circumference, and fat mass, as measured by bioimpedance, but not with height or leptin levels. Interestingly, irisin levels paralleled body weight reduction after the dietary treatment (week 8) and again returned to the baseline levels at 24 weeks in those patients regaining the lost weight.Conclusions: Irisin strongly reflects body fat mass, suggesting that the irisin circulating levels are conditioned by adiposity level. Am. J. Hum. Biol. 26:198-207, 2014.

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“…Therefore, irisin can regulate the amount of intra-liver triglyceride through FGF21. Furthermore, a decline in the plasma irisin causes a rise in ALT and AST, signifying that irisin can function as a protective against liver steatosis (16).…”

Section: Discussionmentioning

confidence: 99%

“…A recent research in this regard made it evident that physical activity can result in the lowering of liver osteotasis. The co-activator of this lowering is unknown, but it was recently shown that the levels of plasma irisin is inversely related to the triglyceride content of the liver and it was suggested that irisin was involved (16).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain. Objective(s). This study aims at comparing the effects of resistance and endurance training on FNDC5 (the precursor of irisin myokine) gene expression in male rat liver tissues.. Methods. Fifteen Wistar male rats (aged 10-12 weeks with an average weight of 331.8 ±63.09 gr) were used. After being taken to the animals' laboratory, the subjects were randomly assigned to three equal groups viz: control (N=5), endurance (N=5) and resistance (N=5). For the purpose of tissue sampling, all these subjects were anesthetized 72 hours after the experiment had been completed. The liver tissue was immediately removed and then quickly frozen in liquid nitrogen and kept at a temperature of -80o C until RNA extraction. FNDC5 relative gene expression was identified by Real-time PCR method. Results. Data analysis revealed a significant difference in FNDC5 gene expression among the groups (P=0.008, Chi Square=31.791). No significant difference was observed between the resistance training and endurance training groups in FNDC5 gene expression, though (P=0.959). Conclusion. It can be established that both resistance and endurance training can similarly affect the production and secretion of exerciseinduced myokines, including FNDC5 irisin, which can in turn protect against obesity and its impacts on the liver tissue by stimulating the process of browning of white fat.

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Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Cited by 195 publications

References 33 publications

Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk

Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

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