Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement

Shirvani, Hossein; Rahmati-Ahmadabad, Saleh

doi:10.1186/s12944-019-0960-4

Cited by 23 publications

(20 citation statements)

References 40 publications

(48 reference statements)

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“…Once converted from white to brown, adipose tissue takes on the function of dispersing heat energy, while white adipose tissue is responsible for storing energy. This event, in turn, causes an increase in total body energy expenditure [32].…”

Section: Discussionmentioning

confidence: 99%

The influence of concurrent training intensity on serum irisin and abdominal fat in postmenopausal women

Rashti

Mehrabani

Damirchi

et al. 2019

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Introduction: Menopause seems to be among the factors related to the development of prediabetes and central obesity. Conversely, physical activity may have a major role in reducing metabolic syndrome in women of postmenopausal age. Material and methods: Forty-eight postmenopausal active and sedentary women within the ages of 45-65 years were randomized to four groups: 1) high-intensity concurrent interval exercise (HCI; n = 15), 2) moderate-intensity continuous concurrent exercise (MCC; n = 14), 3) control daily active (CDA; n = 10), and 4) control sedentary (COS; n = 9). The subjects in the preceding training groups exercised three times per week for 50-65 min/session with high/moderate concurrent exercise for 10 weeks. The levels of serum irisin, insulin sensitivity, abdominal fat distribution (visceral and subcutaneous), and total abdominal fat were measured at baseline and post-test. Results: This study showed that the HCI group had a significantly increased serum irisin (p < 0.001), stimulated favorable alterations in insulin sensitivity status (p = 0.003), and significantly decreased subcutaneous, visceral and, total abdominal fat (p < 0.001). Also, the insulin sensitivity status was significantly increased (p = 0.01) and subcutaneous abdominal fat significantly decreased in the MCC group (p = 0.018). However, this study's results did not find a considerable correlation between insulin sensitivity, irisin level, weight loss and abdominal fat distribution. Conclusions: High-intensity concurrent exercise has a greater influence on improving most metabolic-related parameters than moderate-intensity concurrent exercise.

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Section: Discussionmentioning

confidence: 99%

The influence of concurrent training intensity on serum irisin and abdominal fat in postmenopausal women

Rashti

Mehrabani

Damirchi

et al. 2019

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“…At present, the design of many studies increasing the concentration of Nesfatin-1 in the body is based on direct injection in the brain. Hossein Shirvani et al [65] found that exercise or supplementation of flaxseed oil could also increase the level of Nesfatin-1 in the body, which reduces the food intake through calcium signaling pathways, thereby decreasing the occurrence of obesity. Aside from regulating food intake, many researchers started to focus on the relationship between brown adipose and Nesfatin-1.…”

Section: The Nervous System Regulates the Occurrence Of Obesity Thmentioning

confidence: 99%

Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity

Song

Wang

Zhang

et al. 2019

IJMS

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Nowadays, high epidemic obesity-triggered hypertension and diabetes seriously damage social public health. There is now a general consensus that the body’s fat content exceeding a certain threshold can lead to obesity. Calcium ion is one of the most abundant ions in the human body. A large number of studies have shown that calcium signaling could play a major role in increasing energy consumption by enhancing the metabolism and the differentiation of adipocytes and reducing food intake through regulating neuronal excitability, thereby effectively decreasing the occurrence of obesity. In this paper, we review multiple calcium signaling pathways, including the IP3 (inositol 1,4,5-trisphosphate)-Ca2+ (calcium ion) pathway, the p38-MAPK (mitogen-activated protein kinase) pathway, and the calmodulin binding pathway, which are involved in biological clock, intestinal microbial activity, and nerve excitability to regulate food intake, metabolism, and differentiation of adipocytes in mammals, resulting in the improvement of obesity.

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“…Exercise-activated mitophagy was mediated by the irisin/FNDC5-PINK1/Parkin-LC3/P62 pathway, which could significantly increase the level of myocardial anti-oxidation and improve cardiac function [ 13 ]. As the myogenic exerkine [ 8 ], irisin could result in clearer cardioprotection by exercise training [ 14 , 15 ], However, whether this protective effect works through PINK1/Parkin-mediated mitophagy still lacks experimental evidence. Furthermore, whether the cardioprotective effect of exercise also works through this mechanism and which exercise mode is better in MI myocardium still remain to be studied.…”

Section: Introductionmentioning

confidence: 99%

Exercise Training Enhances Myocardial Mitophagy and Improves Cardiac Function via Irisin/FNDC5-PINK1/Parkin Pathway in MI Mice

Qin

Liang

et al. 2021

Biomedicines

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Myocardial infarction is the major cause of death in cardiovascular disease. In vitro and in vivo models are used to find the exercise mode which has the most significant effect on myocardial irisin/FNDC5 expression and illuminate the cardioprotective role and mechanisms of exercise-activated myocardial irisin/FNDC5-PINK1/Parkin-mediated mitophagy in myocardial infarction. The results indicated that expression of irisin/FNDC5 in myocardium could be up-regulated by different types of exercise and skeletal muscle electrical stimulation, which then promotes mitophagy and improves cardiac function and the effect of resistance exercise. Resistance exercise can improve cardiac function by activating the irisin/FNDC5-PINK1/Parkin-LC3/P62 pathway, regulating mitophagy and inhibiting oxidative stress. OPA1 may play an important role in the improvement of cardiac function and mitophagy pathway in myocardial infarction mice by irisin-mediated resistance exercise. Resistance exercise is expected to become an effective therapeutic way to promote myocardial infarction rehabilitation.

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Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement

Cited by 23 publications

References 40 publications

The influence of concurrent training intensity on serum irisin and abdominal fat in postmenopausal women

The influence of concurrent training intensity on serum irisin and abdominal fat in postmenopausal women

Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity

Exercise Training Enhances Myocardial Mitophagy and Improves Cardiac Function via Irisin/FNDC5-PINK1/Parkin Pathway in MI Mice

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