Irisin: A potentially candidate marker for myocardial infarction

Kuloğlu, Tuncay; Aydın, Suna; Eren, Mehmet Nesimi; Yılmaz, Musa; Şahin, İ̇brahim; Kalaycı, Mehmet; Sarman, Emine; Kaya, Nihat; Yılmaz, Osman; Türk, Ahmet; Aydin, Y.; Yalçın, Mehmet Hanifi; Uras, Nimet; Gürel, Ali; İlhan, Selçuk; Gül, Evrim

doi:10.1016/j.peptides.2014.02.008

Cited by 106 publications

(79 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Due to the small number of analysed cases, the difference in normality and equality of variances between gene expression was also reported in adipose tissue [9][10][11]. To date, numerous studies have been published evaluating the role of irisin in pathological entities [12,13] and thyroid dysfunction in metabolic disorders [14][15][16]. To the best of the authors' knowledge, the first clinical presentation of the thyroid function impairment influence on serum irisin level was published in 2014.…”

Section: Discussionmentioning

confidence: 99%

Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

Zybek-Kocik¹,

Sawicka‐Gutaj²,

Wrotkowska³

et al. 2016

Endokrynologia Polska

View full text Add to dashboard Cite

Introduction: Irisin, a cleaved and secreted part of the transmembrane protein FNDC5, is a recently discovered adipo-myokine that is said to have a significant influence on body metabolism. Changes in thyrometabolic state may also alter the serum irisin level. Since already reported data are not fully consistent, the aim of the present research is to evaluate the time-dependent changes in serum irisin level in patients affected by overt hypothyroidism. Material and methods:The study involved 36 subjects -two groups of 12 patients with long-lasting (AITD) and short-term (TC) overt hypothyroidism, and a control group (CG) of 12 subjects, matched for age and gender. Serum irisin level, thyrometabolic state, creatine kinase (CK -muscle damage marker), glucose, and insulin concentration were assessed and compared between groups. Results: The irisin level was significantly lower in AITD than in TC and CG (p = 0.02; p < 0.01; respectively) patients, with no statistical difference between TC and CG (p > 0.05). There was no significant difference between free triiodothyronine and free thyroxine levels in AITD and TC patients (p > 0.05). CK concentration was significantly higher in AITD than in CG patients (p < 0.01) with no difference between AITD and TC patients (p > 0.05) as well as TC and CG patients (p > 0.05). Additionally, the CK level negatively correlated with the irisin level (r = -0.58; p < 0.01).

show abstract

Section: Discussionmentioning

confidence: 99%

Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

Zybek-Kocik¹,

Sawicka‐Gutaj²,

Wrotkowska³

et al. 2016

Endokrynologia Polska

View full text Add to dashboard Cite

show abstract

“…Besides, immunoreactivity of irisin has been detected in the salivary glands, kidneys, ovary, testes, rectum, intracranial arteries, and stomach, etc. (8,(10)(11)(12). FNDC5 mRNA which is the precursor of irisin is secreted from the seminal vesicles, penis, and testes (11,14).…”

Section: Discussionmentioning

confidence: 99%

“…It is also produced in many tissues including adipose tissue, liver, heart and salivary gland (7)(8)(9)(10)(11)(12). Irisin is a component of fibronectin type 3-domain containing 5 (FNDC5) protein.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Value of Irisin and Visfatin in Experimental Testicular Torsion

Saraç¹,

Yeniocak²,

Sarsu³

et al. 2018

Haseki

View full text Add to dashboard Cite

Aim: Testicular torsion (TT) is one of the most important causes of acute scrotum in children and young men. Very scarce number of serum laboratory parameters might be used in the early diagnosis of patients with TT. We planned this study in consideration of the possible significance of the changes in serum irisin and visfatin levels in the diagnosis of TT. Methods:We used 28 rats in four groups. In the control group, blood samples and specimens of testicular tissue were collected at 2 nd and 4 th hours after torsion. In the torsion groups, the left testis was twisted, and blood samples and specimens of the testicular tissue were collected at the 2 nd and 4 th hours for analysis.Results: There was no statistically significant difference in mean irisin and visfatin levels at the 2 nd and 4 th hours between rats with TT and controls. There was no statistically difference between mean irisin and vistatin levels at the 2 nd hour and at the 4 th hour in torsion and control groups. Conclusion:In our experimental TT method, we could not find a statistically significant difference between serum levels of irisin and visfatin. We assume that further studies are needed on this issue. Keywords: Testicular torsion, experimental, irisin, visfatinAmaç: Testis torsiyonu (TT) çocuklar ve genç erkeklerdeki akut skrotumun en önemli nedenlerinden biridir. TT'li hastalarda erken tanıda kullanılabilecek serum laboratuvar parametreleri oldukça sınırlıdır. Biz de bu çalışmamızı, TT tanısında irisin ve visfatin'in serum düzeylerindeki değişimin anlamlı olabileceğini düşünerek planladık.Yöntemler: Çalışmamızda dört grupta 28 sıçan kullanıldı. Kontrol gruplarında gubernakulum ortaya konduktan sonra 2. ve 4. saatlerde kan ve testis dokuları alındı. Torsiyon gruplarında ise sol testise torsiyon uygulandıktan sonra 2. ve 4. saatlerde kan ve testis dokuları inceleme için alındı. Bulgular: TT olan ratlarda 2. ve 4. saat irisin ve visfatin değerlerinin ortalamalarında kontrol grubuna göre anlamlı fark saptanmadı. Torsiyon grubu ve kontrol gruplarının 4. saatteki irisin ve visfatin ortalamaları ile 2. saat ortalamaları arasında da istatistiksel olarak anlamlı fark saptanmadı. Sonuç:Oluşturduğumuz deneysel TT modelinde, irisin ve visfatinin serum düzeylerinde istatistiksel olarak anlamlı fark bulamadık. Bu konuda ek çalışmalara ihtiyaç olduğunu düşünmekteyiz.

show abstract

“…Concurrently, the PCR assay also demonstrated a significant increase in irisin mRNA levels. An empirical study by Kuloğlu et al (15) reported that irisin levels decreased during the first 24 h of MI. They hypothesized that the decrease in irisin could mitigate ATP loss and provide energy to cells that are in need of energy.…”

Section: Discussionmentioning

confidence: 99%

Irisin levels increase during experimentally induced acute myocardial infarction

Sarioğlu¹,

Korkmaz²

2016

Curr Res Cardiol

View full text Add to dashboard Cite

BACKgROunD: Irisin is a hormone involved in energy metabolism. To date, however, there are scant data regarding irisin levels in infarcted tissues. OBjECTIVE: To evaluate changes in irisin levels in the cardiac tissue of rats during experimentally induced myocardial infarction (MI). METhODS: A total of 21 rats, comprising three groups of seven animals each (MI-1, MI-2 and a control group), were used. Isoproterenol (150 mg/kg once daily for two days ) was used to induce acute MI. The rats in the MI-1 group were evaluated at the end of the first week after the development of MI; rats in MI-2 were evaluated at the end of the second week after the development of MI. Following decapitation, irisin levels in the removed cardiac tissue were examined using polymerase chain reaction and immunohistochemical methods. RESuLTS:Following Masson trichrome stain, irisin levels were found to be increased in the cardiac tissue of MI-1 and MI-2 rats compared with the control group. Furthermore, polymerase chain reaction findings demonstrated that messenger RNA levels of irisin increased by a mean (± SD) factor of 23.3±0.2 in MI-1 rats and 15.9±0.3 in MI-2 rats compared with the control group (P=0.001 for both groups). In addition, immunohistochemical methods revealed that the strength and prevalence of irisin immunoreactivity displayed a significant increase in MI-1 rats (+3 strength) and MI-2 rats (+2 strength) compared with the control group (+1 strength) (P=0.01).COnCLuSIOn: The present study demonstrated an increase in irisin levels in the cardiac tissue of rats with experimentally induced MI. Further studies will determine the significance of this increase in the pathogenesis of MI.

show abstract

Irisin: A potentially candidate marker for myocardial infarction

Cited by 106 publications

References 24 publications

Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

The Diagnostic Value of Irisin and Visfatin in Experimental Testicular Torsion

Irisin levels increase during experimentally induced acute myocardial infarction

Contact Info

Product

Resources

About