Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

Abstract

Introduction: Irisin, a cleaved and secreted part of the transmembrane protein FNDC5, is a recently discovered adipo-myokine that is said to have a significant influence on body metabolism. Changes in thyrometabolic state may also alter the serum irisin level. Since already reported data are not fully consistent, the aim of the present research is to evaluate the time-dependent changes in serum irisin level in patients affected by overt hypothyroidism. Material and methods:The study involved 36 subjects -two groups of 12 patients with long-lasting (AITD) and short-term (TC) overt hypothyroidism, and a control group (CG) of 12 subjects, matched for age and gender. Serum irisin level, thyrometabolic state, creatine kinase (CK -muscle damage marker), glucose, and insulin concentration were assessed and compared between groups. Results: The irisin level was significantly lower in AITD than in TC and CG (p = 0.02; p < 0.01; respectively) patients, with no statistical difference between TC and CG (p > 0.05). There was no significant difference between free triiodothyronine and free thyroxine levels in AITD and TC patients (p > 0.05). CK concentration was significantly higher in AITD than in CG patients (p < 0.01) with no difference between AITD and TC patients (p > 0.05) as well as TC and CG patients (p > 0.05). Additionally, the CK level negatively correlated with the irisin level (r = -0.58; p < 0.01).

Growth Hormone Treatment Increases Plasma Irisin Concentration in Patients with Turner Syndrome

“…Therefore, we removed the impact of pubertal status and sex hormone fluctuations in our study. Additionally, the data regarding the relationship between thyroid function and irisin show a profound impact of abnormal thyroid function on Ir concentration [27,28].…”

Irisin and Autophagy: First Update

“…The circulating level of irisin is related also to the phenotype of different disease. For example, modulation of irisin concentrations were described in obese subjects, in patients with type 2 diabetes (T2DM) [ 53 ], chronic renal disease (CKD) [ 54 ], and hypothyroidism [ 55 ].…”

Thyroid hormones modulate irisin concentrations in patients with recently onset hypothyroidism following total thyroidectomy

“…To date, the available data about the relationship between thyroid function and irisin are scarce and somewhat conflicting. In patients with overt hypothyroidism, circulating irisin levels have been described as either increased [5] or decreased [6,8]. Similar discrepancies have been found also among studies which evaluate irisin levels in patient with subclinical hypothyroidism.…”

“…In this regard, it has been proposed that increased TSH might lead to increased adipogenesis and irisin could be produced to keep the fat distribution in balance in the increased white adipose tissue [5]. Irisin has been studied in patients with thyroid dysfunction with somewhat conflicting results [5][6][7][8]. Therefore, it remains to clarify whether the effects of thyroid-axis hormones on metabolism could be possibly mediated by irisin, also because the evidences from interventional human studies that would support a causal effect of thyroid axis on irisin concentrations are currently limited.…”