“…Studies applying Ayahuasca to animal models have argued that chronic exposure may provoke toxic and cognitive-impairment effects, such as neuronal loss (Figueroa, 2012; Pic-Taylor et al, 2015) and increased serotonergic activity that induces neurodegeneration (Jiang et al, 2015). The zebrafish ( Danio rerio ) has attracted scientific attention in recent years, and is at the forefront of developmental biology studies (Grunwald and Eisen, 2002; Kalueff et al, 2014), in addition to being a promising model in predictive validation for drug research (Gerlai et al, 2000; Rico et al, 2007; Luchiari and Chacon, 2013; Chacon and Luchiari, 2014; Sterling et al, 2015; Santos et al, 2016). Both adult and larval zebrafish have been applied in studies approaching basic neuroscience questions and it has been successfully used to understand brain development and functioning in humans due to the high conservation of many molecular pathways, genes and protein products with mammals (Holzschuh et al, 2001; Kaslin and Panula, 2001; Kaslin et al, 2004; McLean and Fetcho, 2004; Faraco et al, 2006; Prober et al, 2006).…”