Irish coffee: Effects of alcohol and caffeine on object discrimination in zebrafish

Santos, Luana Carla dos; Ruiz-Oliveira, Julia; Oliveira, Jéssica Janine de; Silva, Priscila F.; Luchiari, Ana Carolina

doi:10.1016/j.pbb.2016.01.013

Cited by 18 publications

(14 citation statements)

References 81 publications

(102 reference statements)

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“…In this respect, on the second day, once the familiar object was recognized, the fish spent more time around the new object, instead of moving between them. This behavior pattern was also observed in the studies by Oliveira et al (2015) and Santos et al (2016). Another element that could draw the fish's attention is the color of the object.…”

Section: Discussionsupporting

confidence: 78%

Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)

et al. 2016

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The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognition.

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Section: Discussionsupporting

confidence: 78%

Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)

et al. 2016

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“…In this view, our data corroborate other studies showing the zebrafish ability to learn about objects and use the previous acquired information to discriminate a novel environmental feature (Oliveira et al, 2015; Santos et al, 2016; Pinheiro-da-Silva et al, 2017). The ability to learn and change behavior according to one’s experiences is highly valuable to all animal species, as it provides several benefits to fitness.…”

Section: Discussionsupporting

confidence: 91%

“…Studies applying Ayahuasca to animal models have argued that chronic exposure may provoke toxic and cognitive-impairment effects, such as neuronal loss (Figueroa, 2012; Pic-Taylor et al, 2015) and increased serotonergic activity that induces neurodegeneration (Jiang et al, 2015). The zebrafish ( Danio rerio ) has attracted scientific attention in recent years, and is at the forefront of developmental biology studies (Grunwald and Eisen, 2002; Kalueff et al, 2014), in addition to being a promising model in predictive validation for drug research (Gerlai et al, 2000; Rico et al, 2007; Luchiari and Chacon, 2013; Chacon and Luchiari, 2014; Sterling et al, 2015; Santos et al, 2016). Both adult and larval zebrafish have been applied in studies approaching basic neuroscience questions and it has been successfully used to understand brain development and functioning in humans due to the high conservation of many molecular pathways, genes and protein products with mammals (Holzschuh et al, 2001; Kaslin and Panula, 2001; Kaslin et al, 2004; McLean and Fetcho, 2004; Faraco et al, 2006; Prober et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish

Lobão-Soares

Eduardo-da-Silva

Amarilha

et al. 2018

Front. Behav. Neurosci.

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Ayahuasca is a psychoactive brew traditionally used in shamanistic and vegetalistic rituals and has recently received lot of attention due to potential cognitive benefits. Ayahuasca effects are caused by the synergistic interaction of β-carbolines (harmine, harmaline and tetrahydroarmine) contained in Banisteriopsis caapi stalks combined with the N,N-dimethyltryptamine (DMT) from Psychotria viridis leaves, a potent agonist to serotonin (5-HT) receptors. The present study approaches the effects of chronic and acute exposure to two Ayahuasca concentrations (0.1 and 0.5 ml/L) on the cognitive ability to discriminate objects in a one-trial learning task in zebrafish. Based on the combination of concentrations and exposure regimens, we divided adult zebrafish in five treatment groups: acute 0.1 and 0.5 ml/L, chronic 0.1 and 0.5 ml/L, and control 0.0 (n = 20 for each group). Then we tested them in a memory task of object discrimination. Acute Ayahuasca exposed groups performed similarly to the control group, however chronically treated fish (13 days) presented both impaired discriminative performance and locomotor alterations. Overall, these results indicate that Ayahuasca is a potent psychoactive drug that, in chronic exposure, negatively affects mnemonic parameters in zebrafish. In single exposure it does not affects cognitive performance, but the higher concentration (0.5) affected locomotion. Moreover, we reinforce the importance of the zebrafish for behavioral pharmacological studies of drug screening, in special to psychedelic drug research.

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“…The following groups were tested: control (0 mg/L caffeine; n = 12), chronic 10 mg/ L (n = 14), and chronic 50 mg/L (n = 14). The caffeine concentrations used were based on the behavioral characterization of caffeine effects by Santos et al (2016). To obtain these concentrations, the specific amount of caffeine powder (Sigma-Aldrich #cat C0507) was diluted in the system water.…”

Section: Caffeine Exposurementioning

confidence: 99%

“…In the modern world we are constantly bombarded with information in a multitasking work environment, making it important to focus one's attention even in the face of distractors, a valuable asset for enhanced learning. In this respect, studies have investigated the effects of caffeine on cognition, primarily on attention and learning (Angelucci, Cesario, Hiroi, Rosalen, & Cunha, 2002;Santos, Oliveira, Oliveira, Silva, & Luchiari, 2016).…”

mentioning

confidence: 99%

Coffee time: Low caffeine dose promotes attention and focus in zebrafish

2019

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In this study we investigated the ability of zebrafish to discriminate visual signs and associate them with a reward in an associative-learning protocol including distractors. Moreover, we studied the effects of caffeine on animal performance in the task. After being trained to associate a specific image pattern with a reward (food) in the presence of other, distractor images, the fish were challenged to locate the exact cue associated with the reward. The distractors were same-colored pattern images similar to the target. Both the target and distractors were continually moved around the tank. Fish were exposed to three caffeine concentrations for 14 days: 0 mg/L (control, n = 12), 10 mg/L (n = 14), and 50 mg/L (n = 14). Zebrafish spent most of the time close to the target (where the reward was offered) under the effects of 0 and 10 mg/L caffeine, and the shortest latency to reach the target was observed for the 10-mg/L caffeine group. Both caffeine treatments (10 and 50 mg/L) increased the average speed and distance traveled when compared to the control group. This study confirms previous results showing that zebrafish demonstrate conditioned learning ability; however, low-dose caffeine exposure seems to favor visual cue discrimination and to increase zebrafish performance in a multicue discrimination task, in which primarily focus and attention are required in order to obtain the reward.Caffeine is one of the most consumed stimulants in the world (Ferré, 2008;Lieberman, 1992). It is present in a wide range of products, including coffee, energy drinks, teas, and chocolate. The popularity of this substance lies in its beneficial effects, such as heightened attention and alertness and decreased fatigue

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Irish coffee: Effects of alcohol and caffeine on object discrimination in zebrafish

Cited by 18 publications

References 81 publications

Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)

Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)

It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish

Coffee time: Low caffeine dose promotes attention and focus in zebrafish

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