Iris lymphoma in a pediatric cardiac transplant recipient Clinicopathologic findings

Primary Intraocular Lymphoma

“…93,155,172,189 Iatrogenic immunosuppression may also lead to PIOL. 39,49,120,126,173,218 The cause for the increased incidence in immunocompetent patients is unknown. 155 The Central…”

“…29 PIOL usually occurs in adults from the third to the eighth decades of life, 19,27,107 although cases in infants 39,211 and adolescents are documented. 163,183 The mean age of presentation is in the fifth and sixth decades of life.…”

“…22,54 Rare cases can present with infiltration of the iris or angle 39,202 or as a pseudohypopyon. 48,138 Examination of the posterior segment ( Fig.…”

EBV-induced polymorphic lymphoproliferative disorder of the iris after heart transplantation

“…Posttransplantation lymphoproliferative disorder (PTLD) can be observed in all age groups after transplantation of the kidney, liver, heart, lung, or bone marrow [17]. Taking all solid organ transplants together, the incidence of PTLD is approximately 2-3% [2,3,7,14,17,23]. However, kidney recipients are at a lower risk than heart or lung recipients due to the different immunosuppression regimens [14,17,24].…”

“…Thus, PTLD represents a wide spectrum of B-lymphocyte proliferation. In the majority of cases, there is a predominant population of monoclonal cells embedded in a polymorphic infiltrate [2,7]. Interestingly, the proliferating B-cell clone in PTLD may not only stem from the recipient, but also, less often, from the transplant donor [4,23].…”