EBV-induced polymorphic lymphoproliferative disorder of the iris after heart transplantation

Rohrbach, Jens Martin; Kröber, Stefan; Teufel, T.; Kortmann, Rolf‐Dieter; Zierhut, Manfred

doi:10.1007/s00417-003-0751-4

Cited by 25 publications

(12 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although PTLD is one of the most common conditions occurring after solid organ transplantation, ocular PTLD is very rare with only 19 cases reported in the literature (Table I). Bilateral involvement occurred in around half of the cases [1,4,[9][10][11][12][13]15]. The time interval from transplantation to ocular PTLD varied from 3 months to 10 years.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of intraocular post‐transplant lymphoproliferative disorder with intravenous rituximab

Yeung

Loong

et al. 2014

Pediatric Blood & Cancer

View full text Add to dashboard Cite

We reported a rare case of intraocular post-transplant lymphoproliferative disorder (PTLD) arising in a 3-year-old liver transplant recipient who had a prior history of systemic PTLD. The first PTLD entered remission after treatment with intravenous rituximab and withdrawal of immunosuppressants. One year after remission, she presented with granulomatous uveitis and iris nodules in the right eye. Iris biopsy confirmed recurrence of intraocular PTLD, which resolved completely after a second course of intravenous rituximab.

show abstract

Section: Discussionmentioning

confidence: 99%

Successful treatment of intraocular post‐transplant lymphoproliferative disorder with intravenous rituximab

Yeung

Loong

et al. 2014

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Although the treatment of the above mentioned malignancies would follow own protocols, posttransplantation lymphoproliferative disease, caused in children mostly by EpsteinBarr virus, has recently been shown in a case report to be effectively treated by the use of ex vivo-generated Epstein-Barr virus-specific cytotoxic T lymphocytes. 20 …”

Section: Quiescencementioning

confidence: 97%

Therapy of Uveitis in Children

Zierhut¹,

Doycheva²,

Biester³

et al. 2008

International Ophthalmology Clinics

Self Cite

View full text Add to dashboard Cite

With an incidence of approximately 4.3 to 6 1-3 and a prevalence of 30 patients in 100,000 population, 2,3 uveitis in children may affect approximately 5% to 10% of all uveitis patients. There is general consensus that uveitis in children is different as compared with uveitis in adult patients with regard to both the nature of the underlying disorders and the general course of the various diseases. It also seems that the lens, macula, and optic disc are more susceptible to developing irreversible changes compared with adults, and that druginduced side effects can be both more common and problematic in children.This article will give an update on management of uveitis in children. We will first cover treatment for anterior, intermediate, and posterior uveitis, followed by an update of the drugs used to treat uveitis in children. Finally, the role of the pediatrician in therapy will be discussed.Studies published in the last years have provided considerable information concerning new drugs for the treatment of uveitis in

show abstract

“…Recently, our group published the case of a young boy who had developed severe anterior uveitis with iris nodules and secondary glaucoma. 47 The iris biopsy disclosed PTLD with the presence of EBV and massively elevated viral load. The elimination of EBV finally succeeded with the use of ex vivogenerated EBV-specific cytotoxic T-lymphocytes.…”

Section: Malign Disorders or Neoplasiamentioning

confidence: 98%

“…46,47 It can be induced after all kinds of organ transplantation. Latency between transplantation and manifestation of PTLD varies between a few weeks and several years (mean approximately 3 years).…”

Section: Malign Disorders or Neoplasiamentioning

confidence: 99%

Uveitis in Children

Zierhut¹,

Michels²,

Stübiger³

et al. 2005

International Ophthalmology Clinics

Self Cite

View full text Add to dashboard Cite

Uveitis diagnosis and management in children is a challenge due to the fact that chronic courses are more common. Early diagnosis is often difficult and prognosis is worse compared to adults. n EpidemiologyUveitis in children is less frequent compared to adults. It is estimated that the population-based incidence and prevalence of uveitis in children is 5-to 10-fold lower than in adults. Children constitute only about 5% to 10% of patients with uveitis in most tertiary uveitis clinics. Moreover, forms and causes of uveitis in children differ somewhat from those in adults. Whereas in adult patients anterior uveitis accounts for 50%, intermediate uveitis for 30%, and posterior uveitis for 20%, Cunningham 1 found that posterior uveitis was slightly more common than anterior uveitis in a review of 9 large series: anterior uveitis accounted for 30% to 40% of cases, posterior uveitis for 40% to 50%, intermediate uveitis for 10% to 20%, and panuveitis for 5% to 10%. Most of these series have been reported from tertiary care facilities. 1 The distribution of the different types of uveitis varies with age 2 and between reported series, in part because of a different spectrum of diseases seen in different geographic areas. But recent population-based studies suggest that the majority of children with uveitis 135

show abstract

EBV-induced polymorphic lymphoproliferative disorder of the iris after heart transplantation

Cited by 25 publications

References 19 publications

Successful treatment of intraocular post‐transplant lymphoproliferative disorder with intravenous rituximab

Successful treatment of intraocular post‐transplant lymphoproliferative disorder with intravenous rituximab

Therapy of Uveitis in Children

Uveitis in Children

Contact Info

Product

Resources

About