Iridoids from the roots of<i>Valeriana jatamansi</i>

Xu, Jing; Fang, Lingzhi; Li, Yushan; Guo, Yuanqiang

doi:10.1080/10286020.2011.618804

Cited by 16 publications

(5 citation statements)

References 18 publications

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“…Lin et al () identified 13 acylated iridoids, namely, jatamanvaltrates A–M ( 16 – 28 ) from whole plant. Two new iridoids, jatamanvaltrates N ( 29 ) and O ( 30 ), were also extracted from the roots of V. jatamansi (Xu, Guo, Fang, Li, & Guo, ). Similarly, Wang et al () reported the occcurance of two iridoids, jatamanvaltrates P ( 31 ) and Q ( 32 ), along with three known iridoids, valtrate ( 1 ), rupesin B ( 33 ), and chlorovaltrate ( 34 ) from the roots and rhizomes of V. jatamansi .…”

Section: Valepotriatesmentioning

confidence: 99%

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Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Jugran

Rawat

Bhatt

et al. 2019

Phytotherapy Research

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Valeriana jatamansi Jones (Family: Caprifoliaceae), a high value medicinal plant, was distributed in many countries of Asia. The species possesses important valepotriates and is a good source of flavones or flavone glycosides, lignans, sesquiterpenoids or sesquiterpenoid glycoside, bakkenolide type sesquiterpenoids, phenolic compounds, terpinoids, etc. The use of the species in traditional and modern medicines is well known. For instance, V. jatamansi is very important for its insect repelling and antihelmethic properties. Similarly, sedative, neurotoxic, cytotoxic, antidepressant, antioxidant, and antimicrobial activities of the species in various ailments in the indigenous system of medicine, particularly in Asia, are reported. This review focuses on the detailed phytochemical composition, medicinal uses, and pharmacological properties of V. jatamansi along with analysis of botanical errors in published literature and reproducibility of the biomedical researches on this multipurpose herbaceous species.

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Section: Valepotriatesmentioning

confidence: 99%

“…Valepotriate, jatamanvaltrate N ( 29 ) from the roots of V. jatamansi , exhibited weak neuroprotective activities (Xu, Guo, Fang, et al, ). Jatamanvalterate P ( 31 ) is a novel iridoid ester isolated from V. jatamansi traditionally used for treatment of nervous disorder (Yang et al, ).…”

Section: Medicinal Uses and Pharmacology Propertiesmentioning

confidence: 99%

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Jugran

Rawat

Bhatt

et al. 2019

Phytotherapy Research

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“…Generally, the structures of monoethenoid iridoids contain only one double bond located between C-3 and C-4 ( Lin et al, 2009 ), that is, compounds 1 – 65 ( Figure 4 ). The structures of diene iridoids contain two double bonds located between C-3 and C-4 and between C-5 and C-6, but some are located between C-4 and C-5 and between C-6 and C-7 ( Xu et al, 2012a ; Lin et al, 2014 ). The diene iridoids include compounds 66 – 146 ( Figure 4 ).…”

Section: Phytochemistrymentioning

confidence: 99%

The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry

Wang

et al. 2022

Front. Pharmacol.

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Valeriana plants are members of the Caprifoliaceae family, which include more than 200 species worldwide. We summarized previous reports on traditional clinical applications, bioactivities, and phytochemistry of Valeriana by searching electronic databases of Science Direct, Web of Science, PubMed, and some books. Some Valeriana species have been used as traditional medicines, demonstrating calming fright and tranquilizing mind, promoting Qi and blood, activating blood circulation and regulating menstruation, dispelling wind and eliminating dampness, regulating Qi-flowing to relieve pain, and promoting digestion and checking diarrhea, and treating diseases of the nervous, cardiovascular, and digestive systems, inflammation, gynecology, and others. Pharmacology studies revealed the effects of Valeriana, including sedative, hypnotic, antispasmodic, analgesic, antidepressant, anxiolytic, anticonvulsant, antiepileptic, neuroprotective, antibacterial, antiviral, cytotoxic, and antitumor effects as well as cardiovascular and cerebrovascular system improvements. More than 800 compounds have been isolated or identified from Valeriana, including iridoids, lignans, flavonoids, sesquiterpenoids, alkaloids, and essential oils. Constituents with neuroprotective, anti-inflammatory, cytotoxic, and sedative activities were also identified. However, at present, the developed drugs from Valeriana are far from sufficient. We further discussed the pharmacological effects, effective constituents, and mechanisms directly related to the traditional clinical applications of Valeriana, revealing that only several species and their essential oils were well developed to treat insomnia. To effectively promote the utilization of resources, more Valeriana species as well as their different medicinal parts should be the focus of future related studies. Clinical studies should be performed based on the traditional efficacies of Valeriana to facilitate their use in treating diseases of nervous, cardiovascular, and digestive systems, inflammation, and gynecology. Future studies should also focus on developing effective fractions or active compounds of Valeriana into new drugs to treat diseases associated with neurodegeneration, cardiovascular, and cerebrovascular, inflammation and tumors. Our review will promote the development and utilization of potential drugs in Valeriana and avoid wasting their medicinal resources.

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“…Valepotriates are considered to be the major active components of Valeriana jatamansi Jones . In recent years, many new valepotriates from Valeriana jatamansi Jones have been discovered that show significant antitumor and antianxiety activities . Many of these compounds are used in the treatment of gastrointestinal diseases .…”

Section: Introductionmentioning

confidence: 99%

Flexible and powerful strategy for qualitative and quantitative analysis of valepotriates in Valeriana jatamansi Jones using high‐performance liquid chromatography with linear ion trap Orbitrap mass spectrometry

Wang

Zheng

Deng

et al. 2017

J of Separation Science

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Valeriana jatamansi Jones is an important medicinal plant and its quality is closely related to its region of origin. In the current study, we utilized a flexible and powerful strategy for comprehensive evaluation of the quality diversity for 15 regions in China. The method was based on a hybrid linear ion trap-Orbitrap mass spectrometry platform. For structure characterization, fragmentation patterns were detected by analyzing a series of standard compounds using data dependent multistage mass spectrometry acquisition. A fragment ion database for valepotriates was established, and the acquired data were high throughput filtered by fragment ion search for compound identification. For quantitative purposes, we normalized the mass spectrometry data of 15 samples using SIEVE 2.0 and the differences in composition were analyzed using principal component analysis combined with hierarchical clustering analysis. The results identified a total of 92 compounds from Valeriana jatamansi Jones. Samples from Dali, Kunming, and Baoshan have better qualities and concentrations of the main active constituents. To verify our strategy, we compared the valtrate, acevaltrate, and baldrinal contents using high-performance liquid chromatography with diode array detector. We developed and validated a comprehensive qualitative and quantitative analytical method to achieve quality control of Valeriana jatamansi Jones.

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Iridoids from the roots ofValeriana jatamansi

Cited by 16 publications

References 18 publications

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry

Flexible and powerful strategy for qualitative and quantitative analysis of valepotriates in Valeriana jatamansi Jones using high‐performance liquid chromatography with linear ion trap Orbitrap mass spectrometry

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