Iridoid–loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation

Sozański, Tomasz; Kucharska, Alicja Z.; Rapak, Andrzej; Szumny, Dorota; Trocha, Małgorzata; Merwid-Ląd, Anna; Dzimira, Stanisław; Piasecki, Tomasz; Piórecki, Narcyz; Magdalan, Jan; Szeląg, Adam

doi:10.1016/j.atherosclerosis.2016.10.001

Cited by 75 publications

(69 citation statements)

References 43 publications

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“…Ursolic acid ( 112 ) may ameliorate colitis by regulating NF-κB and MAPK signaling pathways via the inhibition of LPS binding to toll-like receptors 4 (TLR4) on immune cells (Jang et al, 2014). Taking into consideration a wide range of ingredients and general mechanisms responsible for induction or prevention of inflammation, in vitro results fit to conclusions obtained from animal experiments and a clinical study (Sung et al, 2009; Sozanski et al, 2014, 2016; Moldovan et al, 2016). In particular, cornuside ( 6 ) was indicated as an immunomodulatory dogwood-derived compound in a model of sepsis in rats (Jiang et al, 2009).…”

Section: Similarities and Differences Of Pharmacological Effects Or Bsupporting

confidence: 72%

“…As mentioned before these protective effects seem to be based on the same chemical constituents. In animal studies for both plant materials evidence was shown for antihypertensive effects, decreasing blood pressure and reduction of circulating cholesterol concentration (Park et al, 2009; Rafieian-Kopaei et al, 2011; Asgary et al, 2014; Sozanski et al, 2014, 2016; Hosseinpour et al, 2017). The ethanolic extract of C. officinalis fruits has significantly inhibited adipogenesis (87.1%) in 3T3-L1 preadipocytes (Roh and Jung, 2012; Kang et al, 2014).…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

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Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

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Section: Similarities and Differences Of Pharmacological Effects Or Bsupporting

confidence: 72%

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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“…The antioxidant properties of Cornus mas L. fruits have been shown in several other studies using different assay methods. 21,22 In this study, we have investigated the antidiabetic effect of the extract of Cornus mas L. fruits in rats with STZ-induced DM.…”

Section: Discussionmentioning

confidence: 99%

“…The compounds were administered daily throughout the experimental period. The administration dose and duration were selected based on previous studies 21,22,26 and the content of main compounds, total polyphenols (YC: 326.75 ± 7.12 mg gallic acid equivalent per g, RC: 375.30 ± 4.04 mg gallic acid equivalent per g) and antioxidant activity (YC: 2.65 ± 0.03 01 μmol trolox equivalent per g, RC: 2.83 ± 0.01 μmol trolox equivalent per g) of cornelian cherry extracts from yellow and red fruits.…”

Section: Animal Experimentsmentioning

confidence: 99%

Antidiabetic effects of extracts of red and yellow fruits of cornelian cherries (Cornus mas L.) on rats with streptozotocin-induced diabetes mellitus

et al. 2019

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“…The detection of the anthocyanins was performed at a 520 nm wavelength. The chromatographic separation and identification of the targeted anthocyanins was assessed based on their retention times and peak areas with respect to their corresponding standard compounds (Sigma Aldrich, Darmstadt, Germany; Extrasynthese, Lyon, France) and to the chromatographic data stipulated in the literature [16][17][18].…”

Section: Hplc Analysis Of the Anthocyaninsmentioning

confidence: 99%

Co-Microencapsulation of Anthocyanins from Cornelian Cherry Fruits and Lactic Acid Bacteria in Biopolymeric Matrices by Freeze-Drying: Evidences on Functional Properties and Applications in Food

et al. 2020

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Cornus mas was used in this study as a rich source of health-promoting bioactives. The cornelian cherries were used to extract the polyphenols and anthocyanins. The chromatographic profile of the Cornus mas fruit extract revealed the presence of several anthocyanins, mainly delphinidin, cyanidin and pelargonidin glycosides. The extract was co-microencapsulated with Lactobacillus casei ssp. paracasei in a unique combination of whey protein isolates, inulin and chitosan by freeze-drying, with an encapsulation efficiency of 89.16 ± 1.23% for anthocyanins and 80.33 ± 0.44% for lactic acid bacteria. The pink-red colored powder showed a total anthocyanins content of 19.86 ± 1.18 mg cyanidin-3-glucoside/g dry weight (DW), yielding an antioxidant activity of 54.43 ± 0.73 mMol Trolox/g DW. The viable cells were 9.39 × 109 colony forming units (CFU)/g DW. The confocal microscopy analysis revealed the microencapsulated powder as a complex one, with several large formations containing smaller aggregates, consisting of the lactic acid bacteria cells, the cornelian cherries’ bioactive compounds and the biopolymers. The powder was tested for stability over 90 days, showing a decrease of 50% in anthocyanins and 37% in flavonoids content, with no significant changes in antioxidant activity and CFU. The powder showed a significant inhibitory effect against the α-amylase of 89.72 ± 1.35% and of 24.13 ± 0.01% for α-glucosidase. In vitro digestibility studies showed a significant release of anthocyanins in gastric juice, followed by a decrease in intestinal simulated conditions. The functional properties of the powder were tested by addition into a yogurt, highlighting a higher and more stable antioxidant activity at storage when compared to the control.

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Iridoid–loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation

Cited by 75 publications

References 43 publications

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Antidiabetic effects of extracts of red and yellow fruits of cornelian cherries (Cornus mas L.) on rats with streptozotocin-induced diabetes mellitus

Co-Microencapsulation of Anthocyanins from Cornelian Cherry Fruits and Lactic Acid Bacteria in Biopolymeric Matrices by Freeze-Drying: Evidences on Functional Properties and Applications in Food

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