Iridoid Glucosides with Free Radical Scavenging Properties from <i>Fagraea blumei</i>

Cuendet, Muriel; Hostettmann, Kurt; Potterat, Olivier; Dyatmiko, Wahjo

doi:10.1002/hlca.19970800411

Cited by 648 publications

(229 citation statements)

References 13 publications

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“…20,21 Fifty microliters of various concentrations of the oils in methanol were added to 5 mL of a 0.004% 881 Simionatto et al Vol. 18, No.…”

Section: Spectrophotometric Dpph Assaymentioning

confidence: 99%

Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Simionatto¹,

Bonani²,

Morel³

et al. 2007

J. Braz. Chem. Soc.

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O óleo essencial obtido a partir das cascas do caule de Croton urucurana Baillon (Euphorbiaceae) foi analisado por CG e CG-EM. 83 compostos foram identificados, sendo borneol (14,7%), acetato de bornila (5,2%), 1-isopropil-7-metil-4-metileno-1,3,4,5,6,8-hexaidro-2H-naftalen-4a-ol (14,7%), sesquicineol (10,5%) e epóxido de γ-gurjuneno (5,4%) os principais componentes. Para o óleo essencial bruto, foi determinada em 3,21 mg mL -1 a EC 50 no ensaio de atividade antioxidante frente ao radical livre DPPH. A fração do óleo essencial bruto que apresentou atividade antioxidante foi purificada por CCD sobre sílica gel. Análises de CG e CG-EM revelaram que α-bisabolol (38,3%), α-eudesmol (9,3%) e guaiol (8,2%) são os principais componentes da fração antioxidante. A EC 50 medida no teste frente ao DPPH foi de 1,05 mg mL -1 para a fração bioativa. Foi determinada a atividade antimicrobiana do óleo essencial bruto frente a sete bactérias Gram-positivas e Gram-negativas e três fungos. Os valores de CIM medidos variaram de 1,25 a 10,00 mg mL -1 .The essential oil obtained from the stem bark of Croton urucurana Baillon (Euphorbiaceae) was analysed by GC and GC-MS. 83 compounds were identified and borneol (14.7%), bornyl acetate (5.2%), 1-isopropyl-7-methyl-4-methylene-1,3,4,5,6,8-hexahydro-2H-naphthalen-4a-ol (14.7%), sesquicineole (10.5%) and γ-gurjunene epoxide (5.4%) were the main components. The EC 50 value of the crude essential oil in the DPPH free radical scavenging assay was 3.21 mg mL -1 . The fraction of the crude essential oil that presented antioxidant activity was purified by prep-TLC on silica gel. GC and GC-MS analysis revealed that α-bisabolol (38.3%), α-eudesmol (9.3%) and guaiol (8.2%) were the main components of the antioxidant fraction. The EC 50 value measured for the bioactive oil fraction in the DPPH assay was 1.05 mg mL -1 . The antimicrobial activity of the crude essential oil was assayed against seven Gram-positive and Gram-negative bacteria and three yeasts. Measured MIC values ranged from 1.25 to 10.00 mg mL -1 . Keywords:Croton urucurana, essential oil, antioxidant, DPPH assay, antimicrobial acticity IntroductionCroton (Euphorbiaceae) is one of the largest genera of flowering plants, with nearly 1,300 species of herbs, shrubs, and trees that are ecologically prominent and often important elements of secondary vegetation in the tropics and subtropics worldwide. Previous works reported that the essential oils from northeastern Brazilian Croton species, C. zenhtneri, C. nepetaefolius and C. argyrophylloides, exhibited good antioxidant activities. 9 Croton urucurana Baillon (Euphorbiaceae) is a tree commonly found in Paraguay, northern Argentina, southern Brazil, and Uruguay. Three different products from this species are used primarily in folk medicine: the red sap, the stem bark, and the gum exudate. 10 Many pharmacological effects of Croton urucurana have been described in literature, which include wound and ulcer healing, antidiarrhoeic, anticancer, intestinal anti-inflammatory, antioxidant and an...

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“…20,21 Fifty microliters of various concentrations of the oils in methanol were added to 5 mL of a 0.004% 881 Simionatto et al Vol. 18, No.…”

Section: Spectrophotometric Dpph Assaymentioning

confidence: 99%

Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Simionatto¹,

Bonani²,

Morel³

et al. 2007

J. Braz. Chem. Soc.

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“…The hydrogen atom or electron donation ability of the corresponding extracts is measured from the bleaching of purple colored methanol solution of DPPH (Cuendet et al 1997 &Burits andBucar, 2000).…”

Section: Dpph Free Radical and Scavenging Activitymentioning

confidence: 99%

Potential scavenging, antimicrobial activities and total phenolic content achieved by resins for five species of Commiphora

Danial¹,

Majrashi²

2016

Int. J. Adv. Res. Biol. Sci.

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In this study, we will study the biochemical characters of the resins for the different species of Commiphora genus through investigation of the in vitro anti-oxidant activity of the crude extracts of resins for five species of Commiphora. The free radical scavenging activity will be measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Also the total phenolic content was evaluated according to the Folin-Ciocalteu procedure. On the other hand the determination of the inhibitory effects of each of the extracts on the growth of selected bacterial and fungal was investigated on the pathogenic selected species. The results of this study are aiming to help in the development of biochemical analysis of resins which contributed to distinguish between plant species, to employ the plant extracts in the medical field and the possibility of their use in the treatment of many microbial diseases.

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“…32 The ferric reducing/antioxidant power (FRAP) method has also been utilized in many investigations with synthetic organics (Figure 3). To overcome solubility issues of the compounds when the solutions are mixed with FRAP reagent, the original method 33,34 has been modified to contain methanol in 3:2 ratio in water instead of using water as solvent in the preparation of FRAP reagent. In quinolines, antioxidant activity changes in accordance with the functional groups related to the quinoline core.…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 99%

Synthesis and biological evaluation of a new series of 4-alkoxy-2-arylquinoline derivatives as potential antituberculosis agents

Tosun¹,

Arslan²,

İskefiyeli³

et al. 2015

Turk J Chem

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Three new series of 33 quinolone compounds, 2-(2-, 3-, and 4-fluorophenyl)-4-O-alkyl(C 5−15) quinolines (7ak, 8a-k, and 9a-k), were synthesized from 2-(2-, 3-, and 4-fluorophenyl)-2,3-dihydroquinolin-4(1H )-one (4, 5, and 6) by the reaction of alkyl halides under basic conditions in DMF. The new compounds 7a-k, 8a-k, and 9a-k were synthesized from flavonones 4-6, which can be considered new precursors for quinoline synthesis through a one-step reaction. All the target compounds (7a-k, 8a-k, and 9a-k) were evaluated for their in vitro antimicrobial activity against nine test microorganisms. They showed the most activity against Mycobacterium smegmatis with minimum inhibitory concentrations (MIC) of 62.5-500 µ g/mL, indicating their potential uses as antituberculosis agents. Among them 8a-k (m-fluoride) were the most active compounds against M. smegmatis (MIC, 62.5-125 µ g/mL). The newly synthesized title compounds were also evaluated for their in vitro antioxidant activities using DPPH• radical scavenging and FRAP tests. They showed at a low concentration (mg/mL) a range of SC 50 values of 0.03-12.48 mg/mL (DPPH•) and 0-722 µ M (FRAP), respectively. The antioxidant results of compounds 7a-k, 8a-k, and 9a-k revealed that the length of the alkyl chain was negatively correlated with antioxidant capacity.

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Iridoid Glucosides with Free Radical Scavenging Properties from Fagraea blumei

Cited by 648 publications

References 13 publications

Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Potential scavenging, antimicrobial activities and total phenolic content achieved by resins for five species of Commiphora

Synthesis and biological evaluation of a new series of 4-alkoxy-2-arylquinoline derivatives as potential antituberculosis agents

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