Iridium(Ⅲ) complex-based phosphorescent probe for rapid, specific, and sensitive detection of phosgene

Ma, Bin; Wang, Xuefeng; Gao, Shi; Qi, Ling; Xu, Yong; Yang, Jinxing; Zuo, Guomin

doi:10.1016/j.dyepig.2020.108279

Cited by 27 publications

(12 citation statements)

References 49 publications

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“…Further, Ma et al . developed a weak phosphorescence probe Ir−OXIME [121] . The oxime converted to nitrile functional groups in the presence of phosgene, leading to the strong phosphorescence property (figure 11C).…”

Section: Activity‐based Fluorescent Probe For Reactive Mono Carbonylsmentioning

confidence: 99%

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Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

Jana

Baruah

Samanta

2022

Chemistry An Asian Journal

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This review explains various strategies for developing fluorescent probes to detect reactive carbonyl species (RCS). There are several mono and diacarbonyls among 30 varieties of reactive carbonyl species (RCSs) so far discovered, which play pivotal roles in pathological processes such as cancer, neurodegenerative diseases, cardiovascular disease, renal failure, and diabetes mellitus. These RCSs play essential roles in maintaining ion channel regulation, cellular signaling pathways, and metabolisms. Among RCSs, carbon monoxide (CO) is also utilized for its cardioprotective, anti-inflammatory, and anti-apoptotic effects. Fluorescence-based non-invasive optical tools have come out as one of the promising methods for analyzing the concentrations and co-localizations of these small metabolites. There has been a tremendous eruption in developing fluorescent probes for selective detection of specific RCSs within cellular and aqueous environments due to their high sensitivity, high spatial and temporal resolution of fluorescence imaging. Fluorescence-based sensing mechanisms such as intramolecular charge transfer (ICT), photoinduced electron transfer (PeT), excited-state intramolecular proton transfer (ESIPT), and fluorescence resonance energy transfer (FRET) are described. In particular, probes for dicarbonyls such as methylglyoxal (MGO), malondialdehyde (MDA), along with monocarbonyls that include formaldehyde (FA), carbon monoxide (CO) and phosgene are discussed. One of the most exciting advances in this review is the summary of fluorescent probes of dicarbonyl compounds.

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Section: Activity‐based Fluorescent Probe For Reactive Mono Carbonylsmentioning

confidence: 99%

“…Further, Ma et al developed a weak phosphorescence probe IrÀ OXIME. [121] The oxime converted to nitrile functional groups in the presence of phosgene, leading to the strong phosphorescence property (figure 11C). The probe was excellent considering faster response (< 5 s), high selectivity and very low LOD (2.4 nM).…”

Section: Phosgene (Cocl 2 )mentioning

confidence: 99%

Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

Jana

Baruah

Samanta

2022

Chemistry An Asian Journal

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“…Based on this mechanism, carbonyl groups of several uorophores have been substituted with the oxime group, creating feeble "push-pull" based photocaged uorophores with weak uorescence. The resulting oxime-caged uorophores have been used for the detection of diverse chemicals, including hypochlorous acid/ hypochlorite, [50][51][52][53][54][55] phosgene, 56,57 ions, [58][59][60] NO 2 , 61 trichloroisocyanuric acid, 62 and organophosphorous nerve agents. 63 The basis for most of these detections is a deoximation reaction that occurs in the presence of oxidizing agents.…”

Section: Introductionmentioning

confidence: 99%

Oxime as a general photocage for the design of visible light photo-activatable fluorophores

et al. 2021

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“…Due to their low cost, specificity, high sensitivity, and ease of use, many fluorescent probes for phosgene have been reported [5] with two nucleophilic groups as the active site for the reaction, o ‐diamine (including one amine plus one o ‐aromatic nitrogen), [6a–y] one amine plus one o ‐hydroxy group, [7a–c] o ‐dihydroxy [8] group and others, [9a–l] and summarized in Table S1 in the Supporting Information. Among the largest class of probes, with o ‐phenylenediamine as the active site, would produce a similar fluorescence response to nitric oxide (NO), [6e, f] which induces o ‐phenylenediamine to form benzotriazole [10] …”

Section: Introductionmentioning

confidence: 99%

Sensitive and Visual Detection of Phosgene by a TICT‐Based BODIPY Dye with 8‐(o‐Hydroxy)aniline as the Active Site

Chong

et al. 2021

Chemistry A European J

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Phosgene and its substitutes (diphosgene and triphosgene) are widely utilized as chemical industrial materials and chemical warfare agents and pose a threat to public health and environmental safety due to their extreme toxicity. Research efforts have been directed to develop selective and sensitive detection methods for phosgene and its substitutes. In this paper, we have prepared two BODIPY‐based fluorescent probes, o‐Pah and o‐Pha, which are two isomers with different active sites, ortho‐aminohydroxy (3′,4′ or 4′,3′) phenyls at meso position of BODIPY, and compared their sensing performance toward triphosgene. The probe with o‐(4′‐amino‐3′‐hydroxyl), o‐Pha, exhibits better sensing performance over the o‐(3′‐amino‐4′‐hydroxyl), o‐Pah, for instance, a lower limit of detection (LOD) (0.34 nm vs. 1.2 nm), and more rapid response (10 s vs. 200 s). Furthermore, based on the above comparative studies, a red‐fluorescence probe o‐Phae has been constructed through extending 3,5‐conjugation of o‐Pha. The probe o‐Phae displays rapid response (60 s), high sensitivity to triphosgene (LOD=0.88 nm), and high selectivity for triphosgene over relevant analytes including nitric oxide. Finally, a facile test strip for phosgene was fabricated by immobilizing o‐Phae in a polyethylene oxide membrane for sensitive (<2 ppm) and selective detection of phosgene in the gas phase.

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Iridium(Ⅲ) complex-based phosphorescent probe for rapid, specific, and sensitive detection of phosgene

Cited by 27 publications

References 49 publications

Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

Oxime as a general photocage for the design of visible light photo-activatable fluorophores

Sensitive and Visual Detection of Phosgene by a TICT‐Based BODIPY Dye with 8‐(o‐Hydroxy)aniline as the Active Site

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