Iridium Catalyzed C—H Amidation of Benzamides with Phosphoryl Azides in Ionic Liquids

Abstract

( a 西北大学化工学院 西安 710069)

Recent advances in metal directed C–H amidation/amination using sulfonyl azides and phosphoryl azides

“…Once again, the iridium complex catalyst demonstrates its catalytic activity not only in nonpolar solvent media but also in highly polar media such as ionic liquids. 34 In a recent contribution by Ning et al (2021), 192 a novel synthetic methodology was developed for the production of phosphoramides via iridium-catalyzed C–H amidation of benzamides with phosphoryl azides in ionic liquids. This study introduces a direct, efficient, and environmentally friendly strategy for catalyzing the conversion of C–H bonds into amides using a transition metal iridium catalyst.…”

Ruthenium-catalysed direct C–H amidation of 4-aryl-pyrrolo[2,3-d]pyrimidines with acyl/phosphoryl azides

“…3 d , e Subsequently, an iridium-catalyzed C–H phosphoramidation of N -aryl-7-azaindoles, and benzamides with phosphoryl azides has been reported. 4 (Scheme 1). This process produces the benign N 2 gas byproduct.…”