Iranian HIV/AIDS patients with oropharyngeal candidiasis: identification, prevalence and antifungal susceptibility of <i>Candida</i>
 species

Khedri, Soleiman; Santos, André L. S.; Roudbary, Maryam; Hadighi, Ramtin; Falahati, Mehraban; Farahyar, Shirin; Khoshmirsafa, Majid; Kalantari, Saeed

doi:10.1111/lam.13052

Cited by 29 publications

(33 citation statements)

References 28 publications

(67 reference statements)

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“…14 Other factors that predispose oral candidiasis in immunocompetent patients are occlusion trauma, poor oral hygiene, xerostomia, and diabetes. 15,16 Some studies have reported increased virulence of Candida tropicalis in immunocompromised patients; [17][18][19] which is in agreement with the clinical findings of this case report regarding HIV status. It is important to order HIV testing in cases of candidiasis since its association with the virus is common.…”

Section: Discussionsupporting

confidence: 91%

Pseudomembranous candidiasis by Candida tropicalis in an immunocompromised patient: Case Report.

Obando-Pereda

2018

J Oral Res

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Pseudomembranous candidiasis is the most frequent type of infection by Candida spp., and Candida albicans is the most common species to cause it. Candidiasis can be due to other Candida species less frequently, as is the case of Candida tropicalis a pathogenic species that can cause infection in immunocompromised patients. The aim of this case report is to describe a pathological condition produce by Candida tropicalis.

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Section: Discussionsupporting

confidence: 91%

Pseudomembranous candidiasis by Candida tropicalis in an immunocompromised patient: Case Report.

Obando-Pereda

2018

J Oral Res

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“…These 30 articles included description of 45 studies related to different yeast species with QPS status, of which 16 referred to Candida kefyr (teleomorph = Kluyveromyces marxianus) Diba et al, 2018;Garc ıa-Agudo et al, 2018;Hasan and Yassein, 2018;Kaur et al, 2018;Khedri et al, 2018;Simi et al, 2019), 8 to Saccharomyces cerevisiae including Saccharomyces boulardii (corresponding to 7 articles: Lazo-V elez et al, Hasan and Yassein, 2018;Kara et al, 2018;, 10 to Candida famata (teleomorph = Debaryomyces hansenii) Cen et al, 2018;Das et al, 2018;Diba et al, 2018;Hasan and Yassein, 2018;Simi et al, 2019), 6 to Candida pelliculosa (synonymus = Pichia anomala, teleomorph = Wickerhamomyces anomalus) Cen et al, 2018;Jung et al, 2018;, 1 to Candida utilis (teleomorph = Lindnera jadinii) , 1 to Hanseniaspora uvarum , 1 Kluyveromyces lactis and 1 to Schizosaccharomyces pombe . One of these articles was considered relevant to evaluate since it presented new data on antimycotic MIC breakpoints for azoles but it is not associated to any specific yeast TU.…”

Section: Yeastsmentioning

confidence: 99%

“…For 32 of those 45 studies, no potential safety concern was reported, while a potential safety concern was described in the other 13 studies (corresponding to 11 articles: Diba et al, 2018;Das et al, 2018;Jung et al, 2018;Kara et al, 2018;Khedri et al, 2018;Afsarian et al, 2018;: 3 for C. famata (Das et al, 2018;Diba et al, 2018;, 7 for C. kefyr Diba et al, 2018;Khedri et al, 2018;, 1 for C. pelliculosa and 2 for Saccharomyces cerevisiae (Kara et al, 2018;. All these studies reported isolation of the QPS yeasts from opportunistic infections in patients with serious predisposing factors.…”

Section: Yeastsmentioning

confidence: 99%

“…In 2 of those 30 studies (corresponding to 1 article, , the problem was due to a lack of information regarding the source attribution. In 19 studies (corresponding to 15 articles: Afsarian et al, 2018;Diba et al, 2018;Das et al, 2018;Hasan and Yassein, 2018;Jung et al, 2018;Kara et al, 2018;Khedri et al, 2018;Kaur et al, 2018;, the problem was due to predisposing factors in the exposed subject.…”

Section: Yeastsmentioning

confidence: 99%

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Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 10: Suitability of taxonomic units notified to EFSA until March 2019

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2019

EFS2

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The qualified presumption of safety (QPS) procedure was developed to provide a harmonised generic preevaluation to support safety risk assessments of biological agents performed by EFSA's Scientific Panels. The taxonomic identity, body of knowledge, safety concerns and antimicrobial resistance were assessed. Safety concerns identified for a taxonomic unit (TU) are, where possible and reasonable in number, reflected by 'qualifications' which should be assessed at the strain level by the EFSA's Scientific Panels. During the current assessment, no new information was found that would change the previously recommended QPS TUs and their qualifications. The list of microorganisms notified to EFSA from applications for market authorisation was updated with 47 biological agents, received between October 2018 and March 2019. Of these, 19 already had QPS status, 20 were excluded from the QPS exercise by the previous QPS mandate (11 filamentous fungi) or from further evaluations within the current mandate (9 notifications of Escherichia coli). Sphingomonas elodea, Gluconobacter frateurii, Corynebacterium ammoniagenes, Corynebacterium casei, Burkholderia ubonensis, Phaeodactylum tricornutum, Microbacterium foliorum and Euglena gracilis were evaluated for the first time. Sphingomonas elodea cannot be assessed for a possible QPS recommendation because it is not a valid species. Corynebacterium ammoniagenes and Euglena gracilis can be recommended for the QPS list with the qualification 'for production purposes only'. The following TUs cannot be recommended for the QPS list: Burkholderia ubonensis, due to its potential and confirmed ability to generate biologically active compounds and limited of body of knowledge; Corynebacterium casei, Gluconobacter frateurii and Microbacterium foliorum, due to lack of body of knowledge; Phaeodactylum tricornutum, based on the lack of a safe history of use in the food chain and limited knowledge on its potential production of bioactive compounds with possible toxic effects.

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“…First, overuse of antifungal agents, particulary the azole antibiotics. Second, the introduction of highly active antiretroviral therapy has resulted in a signi cant decrease in the incidence of a number of opportunistic diseases and the mortality of AIDS (4). Resistance of Candida species to the azole antifungals (as the main challenge antibiotic susceptibility) is the most prevalent type of resistance to antifungals in these patients.…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity and Antifungal Susceptibility of Candida Albicans Strains Isolated from Lranian HIV+ Patients With Oral Candidiasis

Tamai

Pakbin

Fasaei

2020

Preprint

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Objective: The objectives of this study were to investigate the antifungal susceptibility and genetic diversity of oral Candida albicans strains isolated from HIV+ patients with oropharyngeal candidiasis. A total of 50 C. albicans isolates were cultured on Sabouraud glucose agar containing chloramohenicol. The antifungal susceptibility of C. albicans against fluconazole, clotrimazole, nystatin, amphotericin B, ketoconazole and flucytosine was assessed using disc diffusion method. The genetic diversity of different C. albicans strains was determined using random amplified polymorphic DNA technique. Results: The inhibition zones ranged from 4±1.8 to 40±3.8 mm for fluconazole, 7±1.0 to 37±1.8 mm for ketoconazole, 14±0.8 to24±0.8 mm for amphotericin B, 25±0.0 to 33±0.0 mm for nystatin and 7±4.2 to 40±0.0 mm for clotrimazole. At 90% similarity, three distinct groups were observed. The smallest cluster composed of 3 of 50 C. albicans isolates, whereas the largest cluster composed of 17 of 50 isolates. Of 50 C. albicans isolates, 32%, 28% and 14% were resistant to fluconazole, ketoconazole and clotrimazole, respectively. There were no significant differences among antifungal susceptibility of different C. albicans strains from three genotype clusters.

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Iranian HIV/AIDS patients with oropharyngeal candidiasis: identification, prevalence and antifungal susceptibility of Candida species

Cited by 29 publications

References 28 publications

Pseudomembranous candidiasis by Candida tropicalis in an immunocompromised patient: Case Report.

Pseudomembranous candidiasis by Candida tropicalis in an immunocompromised patient: Case Report.

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 10: Suitability of taxonomic units notified to EFSA until March 2019

Genetic Diversity and Antifungal Susceptibility of Candida Albicans Strains Isolated from Lranian HIV+ Patients With Oral Candidiasis

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