IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound

Nan, Ce‐Wen; Qin, Dui; Wu, Pengying; Xu, Shanshan; Wang, Supin; Wan, Mingxi

doi:10.1016/j.ultsonch.2018.12.021

Cited by 43 publications

(24 citation statements)

References 42 publications

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“…In order to achieve a prolonged circulation time after intravenous (IV) administration, DSPE‐PEG 2K ‐NH 2 was selected to form core–shell–corona nanoparticles blended with PTX‐TL‐PEG 1K ‐NH 2 , in which hydrophobic PTX‐TL and DSPE blocks form the core, and hydrophilic PEG forms the shell. The sonosensitizer IR780 was loaded into the hydrophobic core, which released large amounts of ROS upon focused US irradiation and induced apoptosis . The high ROS levels also boosted PTX release from the IR780/PTL‐NPs by decomposing the ROS‐sensitive TL, which rapidly killed the remaining tumor cells after the initial SDT.…”

Section: Introductionmentioning

confidence: 99%

ROS‐Responsive Blended Nanoparticles: Cascade‐Amplifying Synergistic Effects of Sonochemotherapy with On‐demand Boosted Drug Release During SDT Process

Dong

Guo

et al. 2019

Adv Healthcare Materials

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Sonodynamic therapy (SDT) not only has greater tissue‐penetrating depth compared to photo‐stimulated therapies, but also can also trigger rapid drug release to achieve synergistic sonochemotherapy. Here, reactive oxygen species (ROS)‐responsive IR780/PTL‐ nanoparticles (NPs) are designed by self‐assembly, which contain ROS‐cleavable thioketal linkers (TL) to promote paclitaxel (PTX) release during SDT. Under ultrasound (US) stimulation, IR780/PTL‐NPs produce high amounts of ROS, which not only induces apoptosis in human glioma (U87) cells but also boosts PTX released by decomposing the ROS‐sensitive TL. In the U87 tumor‐bearing mouse model, the IR780/PTL‐NPs releases the drug at the target sites in a controlled manner upon US irradiation, which significantly inhibits tumor growth and induces apoptosis in the tumor tissues with no obvious toxicity. Taken together, the IR780/PTL‐NPs are a novel platform for sonochemotherapy, and can control the spatio‐temporal release of chemotherapeutic drugs during SDT.

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Section: Introductionmentioning

confidence: 99%

ROS‐Responsive Blended Nanoparticles: Cascade‐Amplifying Synergistic Effects of Sonochemotherapy with On‐demand Boosted Drug Release During SDT Process

Dong

Guo

et al. 2019

Adv Healthcare Materials

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“…[119,120] Nanocarriers of sonosensitizers can target tumor tissues through the enhanced permeability and retention (EPR) effect and can make nano sonosensitive drugs concentrate in the tumor tissue for a long time. [121,122] Nanocarriers also have excellent physical and chemical properties, which can realize targeted modification, tumor microenvironment (TME) response, and combined therapy. [123] Therefore, the combination of nanotechnology and sonosensitizers can significantly improve the disadvantages of sonosensitizers to achieve sustainable innovation.…”

Section: Nano Organic Sonosensitizersmentioning

confidence: 99%

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Yang

et al. 2021

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Some acoustically active substances can combine with specific molecules/cells and enable imaging of complex disease processes at the molecular level. [8,9] In parallel, accumulating evidence demonstrates that US is an appealing regimen for managing various diseases including Alzheimer's diseases, cardiovascular diseases, and cancers. [10][11][12][13] According to the frequency, US is usually categorized into high intensity focused US (HIFU; >200 kHz) and low intensity focused US (LIFU; 20-200 kHz). [14] HIFU enables truly non-invasive tumor ablation in clinical applications. [15] There have been tens of thousands of cases reporting HIFU guided by US or magnetic resonance imaging to treat solid organ tumors globally. [16,17] However, recent investigations indicate that the administration of HIFU can lead to adverse events such as skin burn and nerve injury. [18] Theoretically, LIFU with lower intensity can eliminate US-induced overheating and make the treatment safer. LIFU radiation combined with sonosensitizer administration (sonodynamic therapy, SDT), was developed as a suitable therapy alternative by Yumita et al. in 1989. [19] When US activates the preloaded sonosensitizers, they can trigger sensitive reactions to produce reactive oxygen species (ROS), which play a therapeutic role in specific sites through different mechanisms. [20,21] More importantly, due to the excellent regional focusing characteristics and strong tissue penetrating ability of US, SDT has higher therapeutic efficiency and fewer side effects. [22,23] Recent intriguing investigations had been carried out using SDT to treat cancer, cardiovascular disease, and multidrug-resistant (MDR) bacterial infection. [24] Notably, SDT of cancer and atherosclerotic peripheral artery disease (PAD) has been applied in clinical trials, and the results showed high efficacy and favorable safety on patients. [25,26] The sonosensitization efficiency, ROS quantum yield, and accumulation of the sonosensitizers in the target cells are essential prerequisites for SDT. [27,28] Therefore, designing and developing excellent sonosensitizers is an important topic in the development of SDT. Generally, sonosensitizers mainly include organic and inorganic sonosensitizers. Many inorganic sonosensitizers have superior physiochemical properties, but the clinical translation remains unresolved because of nonbiodegradation and potential biosafety issues. However, organic sonosensitizers have the advantages of clear structure and easy metabolism, which is conducive to clinical applications. [24] Sonodynamic therapy (SDT) is a novel noninvasive therapeutic modality that combines low-intensity ultrasound and sonosensitizers. Versus photomediated therapy, SDT has the advantages of deeper tissue penetration, high accuracy, and less side effects. Sonosensitizers are critical for therapeutic efficacy during SDT and organic sonosensitizers are important because of their clear structure, easy monitoring, evaluation of drug metabolism, and clinical transformation. Notably, nanotechnolo...

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“…Shin et al showed that 19F MRI could be used to quantitatively track the US-mediated ablation with PFC NEs [ 362 ]. Nanoemulsions have also been used as sonodynamic agents [ 363 ]. Zhang et al fabricated a sonosensitizer using an IR780 dye incorporated in core–shell NDs.…”

Section: Reviewmentioning

confidence: 99%

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Fateh¹,

Moradi²,

Kohan³

et al. 2021

Beilstein J. Nanotechnol.

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The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.

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IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound

Cited by 43 publications

References 42 publications

ROS‐Responsive Blended Nanoparticles: Cascade‐Amplifying Synergistic Effects of Sonochemotherapy with On‐demand Boosted Drug Release During SDT Process

ROS‐Responsive Blended Nanoparticles: Cascade‐Amplifying Synergistic Effects of Sonochemotherapy with On‐demand Boosted Drug Release During SDT Process

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

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