Ir‐Catalyzed Cascade Reaction Promotes the Formation of Geometrically Selective Enones from Bis‐allyl Alcohols

Abstract

Enone compounds are well-known as useful building blocks that can be converted into a variety of valuable compounds. This study describes a synthetic method to synthesize Eselective or multi-substituted enones by an Ir-catalyzed cascade reaction under reducing conditions. We found that the cascade reaction, including reduction/isomerization/dehydration, pro-ceeds by treating bis-allyl alcohol with Crabtree's catalyst in a hydrogen atmosphere, which forms the desired product with high diastereoselectivity. We investigated acceptable catalysts to the reaction and the synthesis of enone using di-, tri-and tetrasubstituted olefin substrates. Additionally, the given results suggested a hypothesis of reaction mechanism.