IR-808 loaded nanoethosomes for aggregation-enhanced synergistic transdermal photodynamic/photothermal treatment of hypertrophic scars

Abstract

Nanophotosensitizer IR-808-ES is prepared for the PDT/PTT of HSs with the structure of IR-808 aggregating in the ES membrane. IR-808-ES integrates transdermal delivery and the aggregation-enhanced PDT/PTT effect, which enhances the PDT/PTT efficiency for HSs.

Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars

“…And an SEI value higher than 1.5 was considered as scar formation. 35,36 Moreover, collagen volume fraction (CVF) was evaluated to assess the collagen deposition level in HSs.…”

“…And an SEI value higher than 1.5 was considered as scar formation. 35,36 Moreover, collagen volume fraction (CVF) was evaluated to assess the collagen deposition level in HSs. CVF was calculated as the ratio of collagen area to the total area of Masson's staining images.…”

Phage-Ce6-Manganese Dioxide Nanocomposite-Mediated Photodynamic, Photothermal, and Chemodynamic Therapies to Eliminate Biofilms and Improve Wound Healing

“…It is known that the content and distribution of type I and type III collagen play key roles in wound healing, and the higher ratio of type III collagen results in reduced scar formation. 48 Under polarized light, Sirius red staining clearly revealed the collagen distribution (Figure 8C,D; type I: red; type III: green). With PCM and NIR irradiation treatment, the collagen III content was obviously higher than that in other treatment groups (Figure 8E), and CT-FIRE analysis revealed that type III neocollagen was much longer than that of other groups (Figure 8D and Figure S11), suggesting that PDT and PTT resulted in improved neocollagen regeneration and reduced scar formation during wound healing.…”

“…With PCM and NIR irradiation treatment, the collagen III content was obviously higher than that in other treatment groups (Figure 8E), and CT-FIRE analysis revealed that type III neocollagen was much longer than that of other groups (Figure 8D and Figure S11), suggesting that PDT and PTT resulted in improved neocollagen regeneration and reduced scar formation during wound healing. 48 In addition, the lesion contained the highest number of CD45+ cells (mainly of granulocytes in the infection niche) in PBS treatment, indicating more severe infection and inflammation (Figure 8F). Without exception, in PCM application and NIR irradiation, the number of CD45+ cells was the least (Figure 8G).…”

Visible light-driven photodynamic therapy for hypertrophic scars with MOF armored microneedles patch

“…To improve the penetration efficiency of photosensitizers into scar tissue, many transdermal systems have been developed ( Zhang et al, 2019 ; Chen et al, 2020 ; Yu et al, 2022 ). Among them, microneedles patch (MNP) comprising a transdermal patch and hypodermic needles can significantly improve the permeability of drugs ( Indermun et al, 2014 ; Yin et al, 2022 ).…”