Ioxynil and 3,5,3′-triiodothyronine: comparison of binding to human plasma proteins

Ogilvie, Leslie M.; Ramsden, D.

doi:10.1016/0378-4274(88)90167-1

Cited by 12 publications

(2 citation statements)

References 8 publications

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“…Ioxynil (IOX) is an iodine-containing herbicide used for the control of weeds (Takahashi et al 2010). Ioxynil has been shown to bind to the TH transporter protein TBPA, in different species (Ogilvie & Ramsden 1988, Akiyoshi et al 2012. It has also been shown to cause epigenetic changes in DNA, resulting in post-receptor changes (Otsuka et al 2014).…”

Section: Journal Of Molecular Endocrinologymentioning

confidence: 99%

Thyroid function disruptors: from nature to chemicals

Oliveira

Chiamolera

Giannocco

et al. 2019

Journal of Molecular Endocrinology

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The modern concept of thyroid disruptors includes man-made chemicals and bioactive compounds from food that interfere with any aspect of the hypothalamus-pituitary-thyroid axis, thyroid hormone biosynthesis and secretion, blood and transmembrane transport, metabolism and local action of thyroid hormones. This review highlights relevant disruptors that effect populations through their diet: directly from food itself (fish oil and polyunsaturated fatty acids, pepper, coffee, cinnamon and resveratrol/grapes), through vegetable cultivation (pesticides) and from containers for food storage and cooking (bisphenol A, phthalates and polybrominated diphenyl ethers). Due to the vital role of thyroid hormones during every stage of life, we review effects from the gestational period through to adulthood, including evidence from in vitro studies, rodent models, human trials and epidemiological studies.

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Section: Journal Of Molecular Endocrinologymentioning

confidence: 99%

Thyroid function disruptors: from nature to chemicals

Oliveira

Chiamolera

Giannocco

et al. 2019

Journal of Molecular Endocrinology

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“…2) were significantly decreased by bromoxynil (by 41%). Recently, a related compound, ioxynil (an iodinated benzonitril), showed binding specifically to the T4 site of transthyretin and may affect the thyroid of experimental animals (Ogilvie and Ramsden 1988).…”

Section: -Sec-butylphenol (Dinoseb)mentioning

confidence: 99%

Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo

Berg¹,

Raaij²,

Bragt³

et al. 1991

Arch Toxicol

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Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups were analyzed for direct interference with the T4 binding site of transthyretin using a competitive binding assay. Sixty per cent of the compounds were competitive at a concentration level of 100 microM. Relatively strong interactions were observed by several chlorophenols, chlorophenoxy acids and nitrophenols, as well as by individual compounds such as hexachlorobenzene, dicofol, bromoxynil and tetrachlorohydroquinone. Examples from these chemical groups, e.g. pentachlorophenol, 2,4-dichlorophenoxybutyric acid, dinoseb and bromoxynil, also reduced plasma TT4 levels in rats. In addition, bromoxynil decreased plasma TT3 levels. The results suggest the existence of a number of halogenated industrial chemicals with a potential for lowering plasma thyroid hormone levels through interference with hormone transport carriers.

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