Iopamidol myelography in the horse

May, S. A.; Wyn‐Jones, G.; Church, S; Brouwer, G.J.; Jones, R. S.

doi:10.1111/j.2042-3306.1986.tb03597.x

Cited by 18 publications

(6 citation statements)

References 7 publications

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“…The only evidence of toxicity caused by the contrast media in all the clinical, neurological and pathological examinations was the presence of slight extradural oedema in six of ten horses, and a significant increase in the white blood cell numbers and specific gravity of the CSF. The increase in white blood cells after iohexol myelography was, however, markedly less than that recorded 48 h post myelography for metrizamide (range two to 2,110 x 100 wbc/L) (Nyeland et a/ 1980), and slightly less than that recorded four days post myelography for iopamidol (May et a/ 1986). Histopathological changes in the brain and spinal cord were also less than that recorded at 48 h after metrizamide myelography (Nyeland et a/ 1980).…”

Section: Discussionmentioning

confidence: 72%

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Iohexol myelography in the horse

Burbidge

Kannegieter

Dickson

et al. 1989

Equine Veterinary Journal

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Summary Iohexol, a water soluble non‐ionic contrast agent, was evaluated for myelography in the horse. Both 300 and 350 mg iodine/ml iohexol gave diagnostic cervical myelograms. Pathological changes were limited to extradural oedema and an increase in the number of white blood cells and specific gravity in the cerebrospinal fluid two days after myelography. This increase in white blood cells in the cerebrospinal fluid was, however, much less than that recorded by other authors using metrizamide and iopamidol contrast media. These findings indicate that iohexol is a less irritant myelographic contrast agent than those previously evaluated in the horse.

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Section: Discussionmentioning

confidence: 72%

“…A report on the use of iopamidol (May, Wyn-Jones and Church 1986) indicated that it may be a safe, effective contrast agent in the horse. It was evaluated in seven horses, five of which had recovered from anaesthesia and were therefore available for post myelographic assessment.…”

Section: Introductionmentioning

confidence: 99%

Iohexol myelography in the horse

Burbidge

Kannegieter

Dickson

et al. 1989

Equine Veterinary Journal

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“…Both concentrations exhibited slight extradural oedema and increased (mononuclear) white blood cell counts and specific gravity in cerebrospinal fluid (CSF) [175]. Similar changes occur with iopamidol and both are less damaging than metrizamide [145,[175][176][177][178][179][180][181] analogous to other species [182][183][184][185]. Despite the lack of reports confirming use of 350 mg I/mL to be detrimental, most equine clinicians still adhere to human guidelines [104,142,186,187].…”

Section: Intrasynovialmentioning

confidence: 99%

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Nelson

Goodrich

Barrett

et al. 2017

Equine Veterinary Journal

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The use of contrast media in computed tomography (CT) and magnetic resonance imaging (MRI) is increasing in horses. These contrast-enhanced imaging techniques provide improved tissue delineation and evaluation, thereby expanding diagnostic capabilities. While generally considered safe, not all contrast media exhibit the same safety profiles. The safety of contrast media use and descriptions of adverse events occurring in horses are sparsely reported. This review summarises the reported evidence of contrast media use and adverse events that occur in horses, with added contribution from other veterinary species and studies in man for comparison. This comprehensive data set empowers equine clinicians to develop use and monitoring strategies when working with contrast media. Finally, it summarises the current state-of-the-art and highlights the potential applications of contrast-enhanced CT and MRI for assessment of diseased or injured equine tissues, as well as (patho)physiological processes.

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“…Although any contrast medium injected in the subarachnoid space can cause complications including seizure activity and intensification of neurologic signs, the complication rate is higher with metrizamide than with newer nonionic agents. 3,[6][7][8][9] We hypothesized that the increased safety of the newer myelographic agents would make clinical use of standing myelography feasible in the horse.…”

Section: Introductionmentioning

confidence: 99%

Standing Myelography in the Horse Using a Nonionic Contrast Agent

Rose

Abutarbush

Duckett

2007

Vet Radiology Ultrasound

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Standing myelography in the horse has been previously described. In that study, metrizamide was used and significant complications were reported. In recent years, the introduction of less-toxic nonionic contrast media has reduced the incidence of complications. This study was undertaken to determine whether standing myelography using a nonionic contrast medium could provide a diagnostic study and be performed safely in the equine patient. Standing myelography was performed in eight horses. The contrast medium used was iohexol. In five horses a myelogram of diagnostic quality was achieved; in one horse contrast flowed only to the level of C6 and in two horses contrast medium did not reach the cervical subarachnoid space. Owing to the difficulty in achieving good flow of the contrast medium in some horses, this procedure may be of limited utility. However, if puncture of the lumbosacral subarachnoid space can be achieved easily and quickly, standing myelography may be a clinically useful procedure. It may be attempted in cases in which the economic value of the patient makes myelography under general anesthesia impractical. In patients presenting for evaluation of ataxia it may be possible to perform a standing myelogram at the time of CSF sample collection from the lumbosacral space.

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Iopamidol myelography in the horse

Cited by 18 publications

References 7 publications

Iohexol myelography in the horse

Iohexol myelography in the horse

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Standing Myelography in the Horse Using a Nonionic Contrast Agent

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