Iontophoretic delivery of lipophilic and hydrophilic drugs from lipid nanoparticles across human skin

Charoenputtakun, Ponwanit; Li, S. Kevin; Ngawhirunpat, Tanasait

doi:10.1016/j.ijpharm.2015.08.094

Cited by 31 publications

(10 citation statements)

References 24 publications

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“…In these experiments, the skin is maintained between the donor and receptor diffusion chambers, and the permeation of a chemical from the donor chamber into and across the skin is measured. These skin permeation studies provide valuable information in risk assessment related to percutaneous absorption after skin exposure to hazardous chemicals (Flynn, 1990; Frasch et al, 2014), development of topical and transdermal formulations (Nicoli et al, 2006; Roy et al, 1996), evaluation and comparison of dermatological products (Bassani and Banov, 2016; Olivier et al, 2003), assessment of new topical and transdermal drug delivery technologies (Li et al, 2001; Tezel et al, 2004; Xu et al, 2009), and identification of the mechanisms of skin formulations such as permeation enhancers (Chantasart and Li, 2012; Charoenputtakun et al, 2015). These studies can also be used for quality control in product manufacturing (USP725, 2009) and bioequivalence assessment (FDA, 2016; Franz et al, 2009; Lehman and Franz, 2014).…”

Section: Introductionmentioning

confidence: 99%

Transepidermal water loss and skin conductance as barrier integrity tests

Zhang

Murawsky

LaCount

et al. 2018

Toxicology in Vitro

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In vitro skin permeation studies are commonly used in the risk assessment of toxic compound skin exposure. The present study examined the utility of transepidermal water loss (TEWL) and electrical conductance as barrier integrity tests before skin permeation studies in vitro using a large number of skin samples and fentanyl. TEWL and conductance of the skin samples were measured before the permeation experiments in Franz diffusion cells in vitro with a vapometer and low voltage application, respectively. The data were analyzed based on the in vitro permeation results and in vivo skin absorption information from the transdermal fentanyl product labels. The results showed poor correlations between TEWL and electrical conductance for the skin samples. Weak correlations between fentanyl delivery rate (flux × area) and TEWL and skin conductance were observed. For comparison, TEWL and conductance were also examined after skin perturbation with a syringe needle, and both TEWL and conductance values of the skin samples increased after the perturbation. The data suggest that either TEWL of 10 g/m2/h or skin conductance of 0.07 mS/cm2 can be used as exclusion criteria in skin integrity testing to remove skin samples with high permeabilities under the in vitro conditions studied.

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Section: Introductionmentioning

confidence: 99%

Transepidermal water loss and skin conductance as barrier integrity tests

Zhang

Murawsky

LaCount

et al. 2018

Toxicology in Vitro

Self Cite

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“…The methods currently used to perform such studies involve the use of aF ranz diffusion cell [4,5] or ad ialysis bag. [6,7] Both methods require abuffer solution as arelease medium, and aliquots of this acceptorp hase are withdrawn from the beaker and its drug content is measured by using analytical techniques at designated time intervals.…”

Section: Introductionmentioning

confidence: 99%

Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers

et al. 2016

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A new, simple, and fast electrochemical (EC) method has been developed to determine the release profile of piroxicam, a nonsteroidal anti-inflammatory drug, loaded in a drug delivery system based on nanostructured lipid carriers (NLCs). For the first time, the samples were analyzed by using square wave voltammetry, a sensitive EC technique. The piroxicam EC responses allow us to propose a model that explains the experimental results and to subsequently determine the amount of drug loaded into the NLCs formulation as a function of time. In vitro drug release studies showed prolonged drug release (up to 5 days), releasing 60 % of the incorporated drug. The proposed method is a promising and stable alternative for the study of different drug delivery systems.

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“…On the other hand, iontophoresis offers an attractive strategy for transdermal drug delivery with accurate control through electric signals [25][26][27] . This technique employs a mild current to promote charged therapeutic agents across the skin layer and even into the systemic circulation and thus significantly enhances the transdermal delivery of the drug 28,29 . The major advantage of iontophoresis is that the delivery can be achieved with exact controllability of the electrified time and parameters 26 .…”

Section: Introductionmentioning

confidence: 99%

Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery

Yang

Rui

et al. 2020

Microsyst Nanoeng

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The incidence rate of diabetes has been increasing every year in nearly all nations and regions. The traditional control of diabetes using transdermal insulin delivery by metal needles is generally associated with pain and potential infections. While microneedle arrays (MAs) have emerged as painless delivery techniques, the integration of MA systems with electronic devices to precisely control drug delivery has rarely been realized. In this study, we developed an iontophoresis-microneedle array patch (IMAP) powered by a portable smartphone for the active and controllable transdermal delivery of insulin. The IMAP in situ integrates iontophoresis and charged nanovesicles into one patch, achieving a one-step drug administration strategy of “penetration, diffusion and iontophoresis”. The MA of the IMAP is first pressed on the skin to create microholes and then is retracted, followed by the iontophoresis delivery of insulin-loaded nanovesicles through these microholes in an electrically controlled manner. This method has synergistically and remarkably enhanced controlled insulin delivery. The amount of insulin can be effectively regulated by the IMAP by applying different current intensities. This in vivo study has demonstrated that the IMAP effectively delivers insulin and produces robust hypoglycemic effects in a type-1 diabetic rat model, with more advanced controllability and efficiency than delivery by a pristine microneedle or iontophoresis. The IMAP system shows high potential for diabetes therapy and the capacity to provide active as well as long-term glycemic regulation without medical staff care.

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Iontophoretic delivery of lipophilic and hydrophilic drugs from lipid nanoparticles across human skin

Cited by 31 publications

References 24 publications

Transepidermal water loss and skin conductance as barrier integrity tests

Transepidermal water loss and skin conductance as barrier integrity tests

Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers

Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery

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