Iontophoresis of basal insulin controlled delivery based on thermoplastic polyurethane

Morarad, Rawita; Naeowong, Witthawat; Niamlang, Sumonman; Sirivat, Anuvat

doi:10.1016/j.jddst.2022.103756

Cited by 7 publications

(3 citation statements)

References 42 publications

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“…The aim was to enhance the biological functionality over existing electrodes by inhibiting the inflammatory cellular cascade whilst displaying no toxic effect to primary neural cells. The study demonstrated how Dex release can be controlled by CV, sweeping between −0.8 and 0.6 V. [87] Other studies have coated TPU with PANI:PSS and demonstrated enhanced insulin release in the presence of voltage [88] but also onto a porous titanium substrate, further demonstrating coating's versatility to adapt to different material classes. In the latter study, PPy loaded with Dex was electrochemically deposited onto a titanium implant intended for bone grafting and reported an increase in in vitro Dex release under -2 V over 24 h. [89] Coatings also present with their own challenges, such as delamination and limited drug loading.…”

Section: Coatings In Drug Delivery Systemsmentioning

confidence: 87%

“…Other studies have coated TPU with PANI:PSS and demonstrated enhanced insulin release in the presence of voltage [ 88 ] but also onto a porous titanium substrate, further demonstrating coating's versatility to adapt to different material classes. In the latter study, PPy loaded with Dex was electrochemically deposited onto a titanium implant intended for bone grafting and reported an increase in in vitro Dex release under – 2 V over 24 h. [ 89 ]…”

Section: Cps In Drug Deliverymentioning

confidence: 97%

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Electroactive Polymers for On‐Demand Drug Release

Alkahtani,

Elbadawi,

Chapman

et al. 2023

Adv Healthcare Materials

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Conductive materials have played a significant role in advancing society into the digital era. Such materials are able to harness the power of electricity and are used to control many aspects of our daily lives. Conductive polymers (CPs) are an emerging group of polymers that possess metal‐like conductivity yet retain desirable polymeric features, such as processability, mechanical properties and biodegradability. Upon receiving an electrical stimulus, CPs can be tailored to achieve a number of responses, such as harvesting energy, biosensing and stimulating tissue growth. The recent FDA approval of a CP‐based material for a medical device has invigorated their research in healthcare, including as biosensors, tissue engineering grafts and implants. In drug delivery, CPs can act as electrical switches, drug release is achieved at a flick of a switch, thereby providing unprecedented control over drug release. In this review, recent developments in CP as electro‐active polymers for voltage‐stimuli responsive drug delivery systems are evaluated. The review demonstrates the distinct drug release profiles achieved by electro‐active formulations, and both the precision and ease of stimuli response. This level of dynamism promises to yield “smart medicines” and warrants further research. The review concludes by providing an outlook to electro‐active formulations in drug delivery and highlighting their integral roles in healthcare IoT.This article is protected by copyright. All rights reserved

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Section: Coatings In Drug Delivery Systemsmentioning

confidence: 87%

Section: Cps In Drug Deliverymentioning

confidence: 97%

Electroactive Polymers for On‐Demand Drug Release

Alkahtani,

Elbadawi,

Chapman

et al. 2023

Adv Healthcare Materials

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“…Iontophoresis technique also has recently been integrated with wearable devices to electrically control and enhance the permeation of small hydrophilic drug molecules across the skin for HS treatment. The transdermal drug delivery of iontophoresis technique is achieved using a mild current through electrophoresis and electroosmotic ow [21][22][23] . Iontophoresis effectively enhances drug delivery in HS, as demonstrated by the signi cant increase in sodium uorescein delivery and improvement of morning stiffness scores with acetic acid iontophoresis 24,25 .…”

Section: Introductionmentioning

confidence: 99%

Paper battery powered iontophoresis microneedles patch for hypertrophic scar treatment

Jiang,

Gao,

Chen

et al. 2024

Preprint

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Hypertrophic scar (HS) is a plaque fibrous and indurated dermal lesion that may cause physical, psychological, and cosmetic challenges for patients. Intralesional injection of triamcinolone acetonide (TA) is commonly used in clinical practice, which cause unbearable pain and uneven drug delivery within HS tissue. Herein, we developed a paper battery powered iontophoresis-driven microneedle patch (PBIMNP) for self-management and painless treatment of HS. The high integration of PBIMNP was achieved by incorporating a paper battery as the power source for iontophoresis. The transdermal drug delivery strategy of PBIMNP combined microneedles and iontophoresis techniques, involving "pressing and poking, phase transformation, and diffusion and iontophoresis", which can actively deliver 90.19% drug into the HS tissue with excellent in vitro drug permeation performance. PBIMNP administration effectively reduced the mRNA and protein levels, leading to a decrease in the expression of TGF-β1 and Col I associated with HS formation, demonstrating its efficacy in HS treatment. The painless microneedles and wearable design endow the PBIMNP as a highly promising platform for self-administration on HS treatment.

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