Ionophores

Novilla, Meliton N.

doi:10.1016/b978-0-12-385926-6.00089-2

Cited by 7 publications

(5 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatments with ionophore antibiotics are generally not used in medical and veterinary applications because they are toxic to some animals. Horses and other equids are extremely sensitive to ionophore action, and cases of poisoning in cattle, sheep, turkeys, cats, dogs, and rabbits have also been described [57][58][59][60][61][62][63]. However, ionophore antibiotics are generally safe and effective at a therapeutic level in animals.…”

Section: Discussionmentioning

confidence: 99%

Ionophore Antibiotics Inhibit Type II Feline Coronavirus Proliferation In Vitro

Tanaka

Tanabe

Nonaka

et al. 2022

Viruses

View full text Add to dashboard Cite

Feline coronaviruses (FCoVs) infect cats worldwide and cause severe systemic diseases, such as feline infectious peritonitis (FIP). FIP has a high mortality rate, and drugs approved by the Food and Drug Administration have been ineffective for the treatment of FIP. Investigating host factors and the functions required for FCoV replication is necessary to develop effective drugs for the treatment of FIP. FCoV utilizes an endosomal trafficking system for cellular entry after binding between the viral spike (S) protein and its receptor. The cellular enzymes that cleave the S protein of FCoV to release the viral genome into the cytosol require an acidic pH optimized in the endosomes by regulating cellular ion concentrations. Ionophore antibiotics are compounds that form complexes with alkali ions to alter the endosomal pH conditions. This study shows that ionophore antibiotics, including valinomycin, salinomycin, and nigericin, inhibit FCoV proliferation in vitro in a dose-dependent manner. These results suggest that ionophore antibiotics should be investigated further as potential broad-spectrum anti-FCoV agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Ionophore Antibiotics Inhibit Type II Feline Coronavirus Proliferation In Vitro

Tanaka

Tanabe

Nonaka

et al. 2022

Viruses

View full text Add to dashboard Cite

show abstract

“…It is approved by the US Food and Drug Administration to treat ruminant coccidiosis and to improve milk production efficiency in dairy cows. However, in high doses, monensin causes cardiac toxicity, documented in the literature by accidental or intentional administration of higher than recommended doses of monensin to many species, including sheep (6), horses (7), buffaloes (8), swine (9), and calves (10)(11)(12). We used a "pure" form, Monensin, Sodium Salt 97% (Acros Organics N.V., Fair Lawn, New Jersey, USA) in our pilot study.…”

Section: Monensin Sodiummentioning

confidence: 99%

A Pilot Study for Inducing Chronic Heart Failure in Calves by Means of Oral Monensin

Fukamachi,

Litwak,

Zahr

et al. 2010

Int. J Biomed Sci.

View full text Add to dashboard Cite

Introduction: Heart failure remains a major cause of mortality in the United States, despite advancing technologies, newer methods of treatment, and novel devices. To evaluate such novel devices, a large-animal model of chronic heart failure is critical in carrying out preclinical animal studies. Methods: We evaluated the efficacy of oral monensin in inducing stable heart failure in five Jersey calves. Various doses of monensin were administered. Hemodynamics, pressure–volume loops, echocardiographic measurements, extent of tissue perfusion, and histopathologic data were recorded before and after induction of heart failure. Results: Responses were variable in the animals. One experiment showed a significant decrease in cardiac output within one week, associated with simultaneous increases in left atrial pressure, central venous pressure, and mean pulmonary artery pressure. Left ventricular pressure-volume loops showed that the slope of the end-systolic pressure-volume relation decreased markedly between the baseline and terminal study, suggesting a decrease in contractility. Echocardiographic studies indicated a decrease in ejection fraction. Histopathologic analysis in cardiac tissue showed extensive fibrosis and necrosis. Conclusion: We demonstrated the feasibility of inducing and maintaining severe yet stable heart failure for up to 3 weeks in a calf model by administration of oral monensin.

show abstract

“…This use in cattle was phased out in January 2006. Although monensin sodium is safe and effective in target species when used at the recommended dosages [ 14 ], poisoning can occur following incorrect feed mixing, misidentification of the recipient, excessive dosage in the diets of target species, and use in non-recommended species [ 15 , 16 , 17 , 18 ]. The toxicity of monensin to cattle and other species is well documented.…”

Section: Introductionmentioning

confidence: 99%

Supplementary Feed Additives Can Improve Lamb Performance in Terms of Birth Weight, Body Size, and Survival Rate

Ahmadzadeh-Gavahan

Hosseinkhani

Palangi

et al. 2023

Animals

View full text Add to dashboard Cite

To evaluate the effects of supplementation of feed additives in the last trimester of pregnancy on placental characteristics and offspring performance, this study was conducted with 48 estrous-synchronized Ghezel ewes that had randomly been assigned to one of the following six groups (n = 8): ad libitum feeding (AL); feed restriction (RF; 60% of ad libitum intake); feed restriction + propylene glycol (PG); feed restriction + propylene glycol + monensin sodium (MS); feed restriction + propylene glycol + rumen-protected choline chloride (RPC); feed restriction + propylene glycol + monensin sodium + rumen-protected choline chloride (PMC). Birth weight, body size, and rectal temperature of lambs were determined within 24 h of birth. The presence of lambs at 87 days of age was used as an index of survival to weaning. The outcome of this study was that the average placental weight of ewes in the AL and MS groups was the highest and lowest, respectively, among the treatment groups (p < 0.01). RPC ewes presented higher placental efficiency compared to AL, RF, and MS ewes (p < 0.05). The largest and smallest crown-to-rump lengths (CRLs) were observed in PMC and RF lambs, respectively (p < 0.01). In addition, lambs born from PMC, RPC, and PG ewes had a longer curved crown-to-rump length (CCRL) than those born from AL and RF ewes (p < 0.01). The concurrent administration of propylene glycol and rumen-protected choline chloride resulted in the highest birth weight among treatment groups (p < 0.01). Lambs born to PMC and RPC ewes had a higher survival rate and rectal temperature than those born to RF ewes (p < 0.05). It can be concluded that although dietary restriction does not have adverse effects on lambs’ performance compared with ad libitum intake, the combined administration of propylene glycol and rumen-protected choline chloride in the ewes’ restricted diet can improve placental characteristics and subsequently amend lambs’ birth weight and body size. Therefore, the combined administration of these additives can be practiced during feed restriction.

show abstract

Ionophores

Cited by 7 publications

References 64 publications

Ionophore Antibiotics Inhibit Type II Feline Coronavirus Proliferation In Vitro

Ionophore Antibiotics Inhibit Type II Feline Coronavirus Proliferation In Vitro

A Pilot Study for Inducing Chronic Heart Failure in Calves by Means of Oral Monensin

Supplementary Feed Additives Can Improve Lamb Performance in Terms of Birth Weight, Body Size, and Survival Rate

Contact Info

Product

Resources

About