Ionizing radiation and atherosclerosis: Current knowledge and future challenges

Borghini, Andrea; Gianicolo, Emilio Antonio Luca; Andreassi, Maria Grazia

doi:10.1016/j.atherosclerosis.2013.06.010

Cited by 84 publications

(57 citation statements)

References 71 publications

(63 reference statements)

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“…It is usually known that higher level exposure to ionizing radiation causes acute tissue injuries, which can lead to organ failure. At lower levels of exposure, though adverse health effects are not immediately observed, there is a possibility of their late appearance [76]. Soluble uranium is a potential radiotoxic and the population may be exposed to even low levels through inhalation and from drinking water [77,78].…”

Section: Discussionmentioning

confidence: 99%

“…They are regarded as radiological hazards [87]. Some epidemiological studies have provided evidence that an excess risk of cardiovascular diseases may also be associated with low-dose radiation [76]. Uranium mining has been linked to human cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Soluble uranium is a potential radiotoxic and the population may be exposed to even low levels through inhalation and from drinking water [77,78]. Uranium can mix into the drinking water supply during mining processes [76]. A cohort study was done in Finland on people having uranium contaminated water from drilled wells.…”

Section: Discussionmentioning

confidence: 99%

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Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Shahid¹,

Chauhdry²,

Mahmood³

et al. 2015

Pol. J. Environ. Stud.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Shahid¹,

Chauhdry²,

Mahmood³

et al. 2015

Pol. J. Environ. Stud.

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“…It is known that radiation damages vessels and impairs tissue healing through a number of mechanisms, but it is unclear to what extent previous radiation affects intraoperative complications and how reconstructive surgeons should plan accordingly when operating under these circumstances. [1][2][3][4][5] Our group previously demonstrated that there is a significant increase in intraoperative microvascular complications in patients who have undergone radiation before free flap breast reconstruction, but no difference in postoperative complications or major outcomes. 6 Although this was a well-designed study that controlled for multiple factors including concurrent chemotherapy and patient comorbidities, this examination was performed looking specifically at flap complications and issue per flap, including bilateral and unilateral patients.…”

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confidence: 99%

Bilateral Free Flap Breast Reconstruction After Unilateral Radiation

Fracol

Basta

Nelson

et al. 2016

Annals of Plastic Surgery

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“…Cumulaive radiaion exposure is a recognized risk factor for cancer and probably for atherosclerosis 27 , and a dedicated radiaion history should be systemaically collected in the medical records [28][29][30] . The step-up in the quality of this secion of the records is linked to the progressive shit from reference dose to truly delivered doses for that paient in the speciic examinaions.…”

mentioning

confidence: 99%

Radiation safety in the cardiac catheterization laboratory: Our responsibility to change

Picano¹,

Piccaluga²,

Padovani³

et al. 2014

Srce i krvni sudovi

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Pregledni radIntroducion o ver the last 20 years, invasive luoroscopy and intervenional cardiology have expanded significantly in the field of diagnostic studies, intervenions, and device implantaion. The efecive dose (ED) to paients in invasive luoroscopy procedures can range anywhere from 1 to 100 milliSievert (mSv), equivalent to a radiological risk corresponding to 50 to 5000 chest x-rays 1 . The occupaional exposure of intervenional cardiologists can be two to three imes higher than that of diagnosic radiologists 2,3 . The increasing use and complexity of intervenional cardiology techniques have not been matched by increasing awareness and knowledge by prescribers and praciioners. Most doctors -including invasive cardiologists -grossly underesimate the radiaion doses for most commonly requested tests 4,5 . However, this knowledge is crucial for several reasons. First, the dose is proporional to long-term cancer risk, and therefore one must be aware of the dose in order to perform a proper risk-beneit assessment, quintessenial for evaluaing the appropriateness of any given test or procedure. Second, knowing the dose is necessary in order to apply dose opimizaion, intended to achieve the desired diagnosic informaion or therapeuic beneit with the lowest necessary dose. Third, radiaion awareness is essenial for beter protecion of intervenional cardiologists and staf (technicians and nurses), since simple radioprotecion knowledge can reduce occupaional exposure by tenfold, making one's professional life longer and healthier. These are three excellent reasons to pursue a policy of radioprotecion in the cardiac catheterizaion lab [6][7][8] . Determinisic and stochasic risks in the cardiac catheterizaion labThere are two main biological efects of radiaion: tissue reactions (deterministic effects), which occur when the radiaion dose exceeds a speciic threshold and become evident days to months ater exposure as a predictable change in issue occurs, and stochasic effects, which relate to the potenial for future harm to the issue and the body 9, 10 . Medical radiaion from x-rays and nuclear medicine is the largest manmade source of radiaion exposure in Western countries, and accounts for a mean efecive dose of 3.0 milliSievert (mSv) per person per year, equivalent to the radiological risk of 150 chest x-rays. Of these, 0.43 mSv come from intervenional radiology (0.20 mSv) and intervenional cardiology (0.23 mSv). Among adult cardiology paients, luoroscopically-guided diagnosis and intervenion account for 12% of all radiological examinaions performed, and 48% of their total collecive dose. On average, a diagnosic invasive angiogram corresponds to a paient radiaion exposure of about 7 mSv (range 2-16), while coronary stening corresponds to 15 mSv (range 7-57). Progressively higher efecive doses are observed for transcutaneous aoric valvuloplasty (39 mSv), dilaion of total occlusion of coronary arteries (81 mSv, range 17-194) and endovascular thoraco-abdominal aneurysm repair procedure . Most experienced (and most expos...

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Ionizing radiation and atherosclerosis: Current knowledge and future challenges

Cited by 84 publications

References 71 publications

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Bilateral Free Flap Breast Reconstruction After Unilateral Radiation

Radiation safety in the cardiac catheterization laboratory: Our responsibility to change

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