Ionized Calcium Secretion in the Duodenal Juice of Normals, Chronic Alcoholics and Patients with Different Stages of Chronic Alcoholic Pancreatitis

Lohse, J.; Pfeiffer, A.; Kaess, H

doi:10.1007/978-3-642-67924-7_37

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…In AGP patients, pancreatic calcium concentra tions and outputs were significantly greater in ACP than in NAC and AC. Similar results have previously been reported in duodenal juice [1,7,11,19]. Furthermore, hormonal stimulation produced no increase of pan creatic calcium secretion in ACP, but in creased it in NAC and AC.…”

Section: Discussionsupporting

confidence: 79%

“…being only about 10-20% of that observed in the pancreatic juice of NAC. This decrease could explain the high concen trations of ionized calcium which have re cently been observed in the duodenal juice of patients suffering from chronic pancreatitis [1,11,19], In previous work it has been found that there is hypersecretion of protein in AC com pared to NAC [1,9,20,21], The different results obtained in the present work may be because pancreatic juice was collected after the patients had been in hospital for 2-3 weeks alcohol. If this is the explanation it seems that the changes of pancreatic protein secretion created by chronic alcoholism do not last as long as changes in citrate secretion after cessation of alcohol abuse.…”

Section: Discussioncontrasting

confidence: 53%

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Citrate and Calcium Secretion in the Pure Human Pancreatic Juice of Alcoholic and Nonalcoholic Men and of Chronic Pancreatitis Patients

et al. 1985

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Citrate, calcium and protein have been estimated in pure pancreatic juice after a secretin and a CCK injection in 4 patients presenting with alcoholic calcified pancreatitis (ACP), 10 controls without evidence of pancreatic disease, drinking more than 130g alcohol/day, and 10 controls without evidence of pancreatic disease, drinking less than 20 g alcohol/day. Citrate is normally secreted in the pancreatic juice and this secretion increases in parallel with protein after CCK injection. Citrate secretion is significantly decreased in the two alcoholic groups. Calcium secretion is increased in the ACP, and reasons are presented to suggest that this may be due to lesions of the ducts. These modifications could play a role in the formation of pancreatic stones which are mostly built up of calcium carbonate.

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Section: Discussionsupporting

confidence: 79%

Section: Discussioncontrasting

confidence: 53%

Citrate and Calcium Secretion in the Pure Human Pancreatic Juice of Alcoholic and Nonalcoholic Men and of Chronic Pancreatitis Patients

et al. 1985

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“…As we found that ionized calcium concen trations in the duodenal juice are indepen dent of caerulein administration and gall bladder contraction, we suppose that they are a better discriminating factor of different stages of chronic pancreatitis than total cal cium concentrations and outputs [3,[13][14][15][16][17][18] and ionized calcium outputs [18].…”

Section: Discussionmentioning

confidence: 99%

“…In a previous work. Lohse and Pfeiffer [18] demonstrated that in chronic pancreatitis total calcium as well as ionized calcium secretion were en hanced.…”

mentioning

confidence: 99%

Effect of Caerulein on Total and Ionized Calcium Secretion in the Duodenal Juice of Man

Pfeiffer¹,

Lohse²,

Kuntzen³

1984

Digestion

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Previous studies have demonstrated an increase of total calcium secretion in the duodenal juice of healthy subjects after cholecystokinin (CCK) administration superimposed on a continuous secretion infusion. In order to get more detailed information on the physiology of calcium secretion and its dependance on hormonal stimulation, ionized and total calcium were determined in the duodenal juice of 9 volunteers under constant stimulation with secretin and graded caerulein doses; bound calcium was calculated as the difference of total and ionized calcium. The results of total calcium were in good agreement with previously published data. We found that total calcium secretion is mainly determined by bound calcium and bound calcium is mainly secreted together with bile products. Since ionized calcium concentration was independent of caerulein administration it is suggested that its concentration in gallbladder bile must be in good accordance with that of hepatic bile and pancreatic juice together.

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“…(b) Some modifications of pancreatic juice are probably induced by chronic alcohol con- In contrast to protein, bicarbonate con centration is decreased in pure pancreatic juice (but not duodenal juice) of chronic alco holics [28], Citrate which is normally secreted by the pancreas in parallel with protein secretion is decreased in the duodenal juice of alcoholic men compared to nonalcoholic controls [16] ( fig. 9).…”

Section: Biochemical Modifications Of Pancreatic Juice In Alcoholic Cmentioning

confidence: 99%

Alcohol and Pancreatitis

Sarles¹,

Laugier²

1984

Dig Dis

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Ionized Calcium Secretion in the Duodenal Juice of Normals, Chronic Alcoholics and Patients with Different Stages of Chronic Alcoholic Pancreatitis

Cited by 4 publications

References 4 publications

Citrate and Calcium Secretion in the Pure Human Pancreatic Juice of Alcoholic and Nonalcoholic Men and of Chronic Pancreatitis Patients

Citrate and Calcium Secretion in the Pure Human Pancreatic Juice of Alcoholic and Nonalcoholic Men and of Chronic Pancreatitis Patients

Effect of Caerulein on Total and Ionized Calcium Secretion in the Duodenal Juice of Man

Alcohol and Pancreatitis

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