“…In contrast, bicar bonate concentration and sometimes output are de creased [ 10,12], the volume being unchanged. There is an increase in the ratio anionic/cationic trypsinogen [14], The concentration and output of citrate, a secretory cal cium chelator, are decreased [15], Calcium and serum protein secretion are increased [15][16][17], This is probably not directly related to alcohol consumption but is second ary to lesions of the ductal epithelium after the onset of CP [18], In a few tropical regions only, such as Kerala (South India) [19], Zaire [20] and Nigeria [21], alcohol consump tion is not the usual cause of CP. In these areas, the dis ease is generally observed in children or young adults, and the possible pathogenetic role of a diet low in protein with a very low fat content has already been emphasized [ 19],…”