Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Williams, Hywel David; Sahbaz, Yasemin; Ford, Leigh; Nguyen, Tri‐Hung; Scammells, Peter J.; Porter, Christopher John

doi:10.1039/c3cc48650h

Cited by 122 publications

(102 citation statements)

References 25 publications

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“…For example, some biocompatible ILs have already been synthesized including cholinium-based ILs, amino acid-based ILs or pharmaceutically acceptable ILs (11)(12)(13)(14)(15)(16). However, the design of entirely green ILs is still very limited.…”

Section: Introductionmentioning

confidence: 99%

Partition Behavior of Drug Molecules in Cholinium-Based Ionic Liquids

Pei

Zhang

Song

et al. 2015

Separation Science and Technology

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In this paper, a series of ionic liquids (ILs) contains cholinium as cations were prepared. These ILs were used as extractants to separate some model drug molecules. The partition coefficients of these drug molecules between ILs and aqueous solutions were determined. Furthermore, the influence of different extraction parameters was investigated: volume ratio, equilibrium time, pH values, temperature and ILs structure. It is shown that these ILs are highly effective materials for the extraction of drug molecules. The results imply that these ILs may have potential in drug extraction or separation as a new type of media.

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Section: Introductionmentioning

confidence: 99%

Partition Behavior of Drug Molecules in Cholinium-Based Ionic Liquids

Pei

Zhang

Song

et al. 2015

Separation Science and Technology

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“…[22,24] Since 2007, Room Temperature Ionic Liquids (RTILs) containing active pharmaceutical ingredients have aroused strong interests as they limit drugs polymorphism and improve their solubility. [29][30][31][32][33] API-ILs have also been used as solvent for poorly soluble drugs [34][35][36][37][38] and as drug delivery systems in the form of microemulsions [39] and micelles. [40] Drug delivery systems have also been obtained by immobilization of API-ILs into silica either by sol-gel processing, [41] adsorption to silica [42] or into biocompatible poly(L-lactic acid).…”

Section: Introductionmentioning

confidence: 99%

Investigation of pharmaceutically active ionic liquids as electrolyte for the electrosynthesis of polypyrrole and active component in controlled drug delivery

Carquigny

Lakard

et al. 2016

Electrochimica Acta

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“…[1][2][3][4] The emergent physicochemical properties of these materials are associated with the combination of bulk and surface properties of aggregates. 2 Moreover, functionalization of nanoparticles using chemical groups that have more affinity with biological molecules, such as viruses, DNA, and RNA, can have a significant impact on the development of virus detections, environmental monitoring, and bio-probe techniques.…”

Section: Introductionmentioning

confidence: 99%

Elucidating Anion Effect on Nanostructural Organization of Dicationic Imidazolium-Based Ionic Liquids

Frizzo¹,

Bender²,

Gindri

et al. 2016

J. Phys. Chem. C

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This work reports the influence of anion structure (Br -, NO 3 -, BF 4 -, and SCN -) in the aggregation process of ionic liquids (ILs), derived from 1,8-bis(3-methylimidazolium-1-yl)octane, in 4.75% ethanol-water solution (v/v). The aggregation behavior was investigated using small angle x-ray scattering (SAXS), nuclear magnetic resonance (NMR), dynamic light scattering (DLS), and transmission electron microscopy (TEM). Spin-lattice relaxation times (T1), obtained by NMR, indicated that the molecular mobility of the ILs changed when aggregates are formed. 1 H-NMR showed distinct chemical shifts as a function of the concentration of [BisOct(MIM) 2 ][2X] (in which X = Br, NO 3 , SCN, and BF 4 ) in solution. This change was associated with different chemical environments experienced by the hydrogen atoms when the aggregation process occurs.This behavior was characterized by the different types of interactions in the aggregates, in accordance with the anion of the IL structure. The SAXS measurements demonstrated that the distance between two molecules, which function as scattering centers, was dependent on the anion hydrophobicity. Less hydrophobic anions resulted in shorter distances between scattering centers due to their better solvating ability. Due to the lower solvating ability of hydrophobic anions, a larger distance between two scattering centers was observed. Furthermore, ILs with more hydrophobic anions (e.g., BF 4 -) resulted in closely-packed aggregates.

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Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Cited by 122 publications

References 25 publications

Partition Behavior of Drug Molecules in Cholinium-Based Ionic Liquids

Partition Behavior of Drug Molecules in Cholinium-Based Ionic Liquids

Investigation of pharmaceutically active ionic liquids as electrolyte for the electrosynthesis of polypyrrole and active component in controlled drug delivery

Elucidating Anion Effect on Nanostructural Organization of Dicationic Imidazolium-Based Ionic Liquids

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