Investigation of pharmaceutically active ionic liquids as electrolyte for the electrosynthesis of polypyrrole and active component in controlled drug delivery

Carquigny, S.; Lakard, Boris; Lakard, Sophie; Moutarlier, Virginie; Hihn, Jean Yves; Viau, Lydie

doi:10.1016/j.electacta.2016.06.080

Cited by 23 publications

(10 citation statements)

References 63 publications

(66 reference statements)

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“…In published studies, reported applied values range between 0.6 and 2 V [62,63,73,[80][81][82]. A higher potential results in faster release [83][84][85]. For example, -2 V releases fluorescein from nanoporous PPy films 3-4 times faster than -1.5 V [81].…”

Section: Drug Loading and Release Mechanisms For Cpsmentioning

confidence: 99%

“…Cyclic voltammetry has been stated as the most efficient method for stimulation [11], also allowing greater control over release speed through the setting of different scan rates [89]. Beyond the applied electrical potential, stimulation time [86,90]; polymer film roughness, porosity, density and thickness [11,62,66,67,84,91]; the dopant [84,87]; and temperature [83,92] are known to affect and allow greater control over optimising the release profile.…”

Section: Drug Loading and Release Mechanisms For Cpsmentioning

confidence: 99%

See 1 more Smart Citation

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Tandon

Magaz

Balint

et al. 2018

Advanced Drug Delivery Reviews

141

119

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Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment. This review focuses on current state-of-the-art research in electroactive-based materials towards the delivery of drugs and other therapeutic signalling agents for wound care treatment. Future directions and current challenges for developing effective electroactive approach based therapies for wound care are discussed.

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Section: Drug Loading and Release Mechanisms For Cpsmentioning

confidence: 99%

Section: Drug Loading and Release Mechanisms For Cpsmentioning

confidence: 99%

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Tandon

Magaz

Balint

et al. 2018

Advanced Drug Delivery Reviews

141

119

View full text Add to dashboard Cite

show abstract

“…Another strategy is to incorporate antibiotic molecules as dopants within the polypyrrole film. A number of drug molecules, including glutamate, adenosine 5′-triphosphate (ATP), salicylate, dexamethasone, chlorpromazine and dopamine, have been successfully incorporated into polypyrrole and subsequently released using electrical stimulation [10][11][12][13][14][15][16]. The d r u g m o l e c u l e s , a s a n i o n s , a r e a d d e d t o t h e e l e c t r o p o l y m e r i s a t i o n s o l u t i o n , a n d d u r i n g electropolymerisation, they are doped within the growing polymer.…”

Section: Introductionmentioning

confidence: 99%

The formation and properties of polypyrrole doped with an immobile antibiotic

Moloney

Breslin

2019

J Solid State Electrochem

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Oxacillin, a semisynthetic penicillinase-resistant penicillin, was incorporated as a dopant within polypyrrole. The oxacillin-doped polymer was deposited at gold, platinum and the biocompatible substrate, titanium. A doping level of 0.12 was obtained during the early stages of polymer formation. Smooth polymer films were deposited, but more structure was observed in the cross sections of the polymer. This was attributed to a reduction in the concentration of the anionic oxacillin as the interfacial pH decreased due to the electropolymerisation reaction, shifting the equilibrium in favour of the undissociated oxacillin, HOx. Although HOx has poor solubility and may precipitate at the polymer solution interface during formation of the polymer, there was no evidence of any reduction in the conducting properties of the polymer. High charging capacitance values of 12 to 15 mF cm −2 were estimated for the oxidised polymer. These conducting properties were attributed to a slow rate of electropolymerisation that prevented significant acidification at the electrode interface, preventing the build-up of HOx. The oxacillin-doped polypyrrole showed cation exchange properties. Oxacillin was maintained within the polymer, as the polymer was cycled between its oxidised and reduced states to give an immobilised antibiotic with very little oxacillin detected in the solution phase. The application of a layer of chitosan gave rise to a slight reduction in the charging capacitance of PPyOx. However, improved adhesion was observed for the reduced PPyOx with the application of the chitosan layer.

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“…Historically, this molecule has been deeply studied due to its role as a coenzyme, a precursor of structural elements of the cell wall, or as a neurotransmitter . Apart from that, its economical nature compared to other ionic liquid cations has made it an appealing contender for the development of new molten salts, and it has been paired with anions like active pharmaceutical ingredients or amino acids. , Therefore, choline is expected to acquire a predominant role in future research works at laboratory and industrial scale.…”

Section: Introductionmentioning

confidence: 99%

Testing True Choline Ionic Liquid Biocompatibility from a Biotechnological Standpoint

Morandeira

Álvarez

Markiewicz

et al. 2017

ACS Sustainable Chem. Eng.

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This work is a first approach to demonstrate the viability of a quantitative biotechnological removal of choline chloride from aqueous effluents. Despite the much vaunted biocompatibility of this ammonium-based ionic liquid, it was demonstrated (both by an ad-hoc F test recommended by the Organization for Economic Co-operation and Development and flask assays) that different microorganisms able to degrade persistent chemicals were not able to metabolize it. Only a halophilic bacterium, recently isolated in our research group (Halomonas sp.), exhibits the enzymatic mechanism to catalyze the cleavage of the ionic liquid cation. The biotechnological process was optimized by carefully cherry-picking the carbon source and proposing an adaptation strategy. In this way, a complete choline removal was attained in less than 24 h when the surfactant Tween 80 was added to the ionic liquid-containing aqueous effluent.

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Investigation of pharmaceutically active ionic liquids as electrolyte for the electrosynthesis of polypyrrole and active component in controlled drug delivery

Cited by 23 publications

References 63 publications

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

The formation and properties of polypyrrole doped with an immobile antibiotic

Testing True Choline Ionic Liquid Biocompatibility from a Biotechnological Standpoint

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