Ionic liquids in enzymatic catalysis and biochemical methods of analysis: Capabilities and prospects

Muginova, S. V.; Galimova, Anna Z.; Polyakov, A. E.; Шеховцова, Т. Н.

doi:10.1134/s1061934810040027

Cited by 38 publications

(30 citation statements)

References 122 publications

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“…Due to these unique properties, ILs have been widely synthesized and investigated as media for electrodeposition of metals [6][7][8], as a tool for lignocellulosic biomass fractionation [9], catalysis and biocatalysis [10][11][12][13][14][15][16], corrosion inhibition [17][18][19][20], food chemical science [21], and the nuclear industry [22].…”

Section: Introductionmentioning

confidence: 99%

New Eco-Friendly 1-Alkyl-3-(4-phenoxybutyl) Imidazolium-Based Ionic Liquids Derivatives: A Green Ultrasound-Assisted Synthesis, Characterization, Antibacterial Activity and POM Analyses

et al. 2014

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Section: Introductionmentioning

confidence: 99%

New Eco-Friendly 1-Alkyl-3-(4-phenoxybutyl) Imidazolium-Based Ionic Liquids Derivatives: A Green Ultrasound-Assisted Synthesis, Characterization, Antibacterial Activity and POM Analyses

et al. 2014

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“…[109][110][111][112][113][114][115][116][117][118] Ionic liquids are organic salts which are liquids at room temperature. Ionic liquids possess unique properties; they are not volatile or flammable and possess excellent chemical and thermal stability, 119 furthermore, they have been described as environmentally benign 120 which make them an attractive alternative to traditional organic solvents.…”

Section: Ionic Liquidsmentioning

confidence: 99%

Recent trends in whole cell and isolated enzymes in enantioselective synthesis

Milner¹,

Maguire²

2012

Arkivoc

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Modern synthetic organic chemistry has experienced an enormous growth in biocatalytic methodologies; enzymatic transformations and whole cell bioconversions have become generally accepted synthetic tools for asymmetric synthesis. This review details an overview of the latest achievements in biocatalytic methodologies for the synthesis of enantiopure compounds with a particular focus on chemoenzymatic synthesis in non-aqueous media, immobilisation technology and dynamic kinetic resolution. Furthermore, recent advances in ketoreductase technology and their applications are also presented.Keywords: Biocatalysis, kinetic and dynamic kinetic resolution, Baker's yeast, ketoreductases General IntroductionAsymmetric synthesis is the preferential formation of one stereoisomer of a chiral target compound to another; when scientists at GlaxoSmithKline, AstraZeneca and Pfizer 1 examined 128 syntheses from their companies, they found as many as half of the drug compounds made by their process research and development groups are not only chiral but also contain an average of two chiral centres each. 2In 2006 just 25 % were derived from the chiral pool and over 50 % employed chiral technologies. 1In order to meet regulatory requirements enantiomeric purities of 99.5 % were deemed necessary by the FDA. 3 This is one of the biggest challenges which face chemists today, primarily due to the recognition of the fact that different enantiomers of the same compound can interact differently in biological systems. As a consequence, the production of single enantiomers instead of racemic mixtures has become an important process in the pharmaceutical and agrochemical industry. Several routes can lead to the desired enantiomer including transition metal-, [4][5][6] organo-5,7-10 and bio-catalysis [11][12][13][14][15] and these have been thoroughly reviewed in the literature. 16,17 2. Biocatalysis IntroductionBiocatalysis involves the use of enzymes or whole cells (containing the desired enzyme or enzyme system) as catalysts for chemical reactions. A timeline of historic events in biocatalysis and biotechnology is outlined in Table 1. [18][19][20] Reviews and Accounts Novel methodologies for discovering industrial enzymes based on genomic sequencing and phage display (discussed further in Section 1.3), 21,22 as well as highly effective optimisation tools based on chemical, physical and molecular biology approaches, 23 have improved the access to biocatalysts, increased their stability, and radically broadened their specificity. 24This greater availability of catalysts with superior qualities including the use of new bioengineering tools contributed significantly to the development of new industrial processes. Biocatalytic methodologies for organic synthesis were outlined by Woodley et al. in three categories: established, emerging and expanding chemistries as depicted in Figure 1. 25 Enzyme classesBy the late 1950s it had become evident that the nomenclature of enzymes without any guiding authority, in a period when the...

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“…Ionic liquids (ILs) are gaining wide recognition as potential environmental solvents due to their unique properties (Wasserscheid & Keim, 2004, Martínez-Palou, 2007, Martínez-Palou, 2010 and their applications in Organic Synthesis (Wasserscheid & Welton, 2008, Martínez-Palou, 2006, catalysis (Gu et al, 2009, Toma et al, 2009, Olivier-Bourbigou, 2010, biocatalysis (Muginova et al, 2010, Moniruzzaman et al, 2010, in separation (Han & Row 2010), extraction (Poole & Poole, 2010) and dissolution processes (Torimoto et al, 2010, Zakrzewska et al, 2010, nanomaterials synthesis , polymerization reactions (Srivastava, et al, 2009) and electrochemistry (McFarlane et al 2010, Ohno & Fukumoto, 2008. ILs are an excellent alternative to substitute volatile organic solvents in more environmental friendly technologies, also known as "green technologies" (Rogers & Seddon, 2002) since their very low vapor pressures, their thermal and chemical stability, their ability to act as catalysts, and their non-flammability and non-corrosive properties which decreases the risk of worker exposure and the loss of solvent to the atmosphere.…”

Section: Introductionmentioning

confidence: 99%