Ionic liquid transdermal delivery system: Progress, prospects, and challenges

Lü, Beibei; Liu, Tianqi; Wang, Hao; Wu, Chengyu; Chen, Hanjun; Liu, Zhe; Zhang, Jiaheng

doi:10.1016/j.molliq.2022.118643

Cited by 38 publications

(31 citation statements)

References 222 publications

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“…It is directly related to the pharmacokinetics, toxicity, efficacy, and pharmacodynamics of a drug delivery system . The pharmacokinetics and pharmacodynamics parameters of drug molecules in transdermal drug delivery systems (TDDSs) are limited without the addition of co-solvents, owing to their insolubility in the oil phase and poor permeability through the skin . The synthesized API-ILs were solubilized in pharmaceutically acceptable CPEs (ethanol, isopropyl alcohol, N -methyl pyrrolidone, and Tween 20), oil media IPM, and nonpolar solvents (cyclohexane, heptane, and octane) to promote their application as transdermally favorable pharmaceuticals (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…14 The pharmacokinetics and pharmacodynamics parameters of drug molecules in trans-dermal drug delivery systems (TDDSs) are limited without the addition of co-solvents, owing to their insolubility in the oil phase and poor permeability through the skin. 3 The synthesized API-ILs were solubilized in pharmaceutically acceptable CPEs (ethanol, isopropyl alcohol, N-methyl pyrrolidone, and Tween 20), oil media IPM, and nonpolar solvents (cyclohexane, heptane, and octane) to promote their application as transdermally favorable pharmaceuticals (Table 1). Visual observation revealed that a clear, transparent solution of each API-IL was formed with these solvents at any ratio, whereas dispersions of the compounds in water or PBS generated cloudy suspensions (Figure S4).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…8−10 These drugs are not effective in topical or transdermal delivery systems owing to the difficulty of formulating them with oil media and the impervious hydrophobic nature of the skin. 3,11 An oil-based formulation can facilitate the permeation of the drugs across the skin because it has excellent surfactant properties, and lipophilic oils act as skin penetration enhancers. 2,12,13 After application to the skin, oils and their components are rapidly metabolized, and the resulting products are quickly excreted without any accumulation in the body; this indicates they are potentially useful and safe penetration enhancers.…”

Section: ■ Introductionmentioning

confidence: 99%

“…18,19 Each drug is highly soluble in water but insoluble in pharmaceutically acceptable solvents/oil media, and each has limited skin permeability, which is a major barrier to transdermal delivery. 3 Four biocompatible anionic fatty acid permeation enhancers, i.e., sodium salts of lauric acid, oleic acid, linoleic acid, and stearic acid, were chosen as model counterions to convert the drugs into transdermally favorable API-ILs. The choice of each permeation enhancer was based on its biocompatibility, the ease with which it could be converted into an IL, its degree of unsaturation, and its superior skin permeation properties (Figure 1B).…”

Section: ■ Introductionmentioning

confidence: 99%

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Transformation of Hydrophilic Drug into Oil-Miscible Ionic Liquids for Transdermal Drug Delivery

Moshikur

Shimul

Uddin

et al. 2022

ACS Appl. Mater. Interfaces

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The transdermal delivery of hydrophilic drugs remains challenging owing to their poor ability to permeate the skin; formulation with oil media is difficult without adding chemical permeation enhancers or co-solvents. Herein, we synthesized 12 oil-miscible ionic liquid (IL) drugs comprising lidocaine-, imipramine-, and levamisole (Lev)-hydrochloride with fatty acid permeation enhancers, i.e., laurate, oleate, linoleate, and stearate as counterions. A set of in vitro and in vivo studies was performed to investigate the potency and deliverability of the transdermal drug formulations. All of the synthesized compounds were freely miscible with pharmaceutically acceptable solvents/agents (i.e., ethanol, N-methyl pyrrolidone, Tween 20, and isopropyl myristate (IPM)). In vitro permeation studies revealed that the oleate-based Lev formulation had 2.6-fold higher skin permeation capability than the Lev salts and also superior ability compared with the laurate-, linoleate-, and stearate-containing samples. Upon in vivo transdermal administration to mice, the peak plasma concentration, elimination half-life, and area under the plasma concentration curve values of Lev-IL were 4.6-, 2.9-, and 5.4-fold higher, respectively, than those of the Lev salt. Furthermore, in vitro skin irritation and in vivo histological studies have demonstrated that Lev-IL has excellent biocompatibility compared with a conventional ionic liquid-based carrier. The results indicate that oil-miscible IL-based drugs provide a simple and scalable strategy for the design of effective transdermal drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Transformation of Hydrophilic Drug into Oil-Miscible Ionic Liquids for Transdermal Drug Delivery

Moshikur

Shimul

Uddin

et al. 2022

ACS Appl. Mater. Interfaces

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“…We are well aware of many excellent reviews on the use of ILs in drug delivery. [7][8][9] But to the best of our knowledge, there is no review existed in biomedical applications of CAGE. Fig.…”

Section: Introductionmentioning

confidence: 99%

An overview of biomedical applications of choline geranate (CAGE): a major breakthrough in drug delivery

et al. 2022

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Ionic Liquid Based Treatment – A Potential Strategy to Modify Bacterial Cellulose

et al. 2023

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The constant need for advanced materials led by modern research continues the exploitation of old remedies and innovation to find new solutions. The use of ionic liquids (ILs) as solvents has revolutionized modern chemical research. The non‐toxic green technology has inspired new paradigms in chemical reactions and synthesis. Developing nontoxic materials for industrial and biomedical applications has endorsed the use of ILs in synthesis and fabrication. In terms of biomedical materials, the exploration for novel technologies to deal with chronic and nonhealing injuries desires degradable materials. One of the vastly used biomaterials is cellulose, which is nondegradable on its own unless digested by special enzymes produced by bacteria in nature. Bacterial cellulose (BC) is a naturally occurring more refined and purified form of cellulose which again is nondegradable on its own. Looking for technologies that can modify the BC in situ or ex situ is a challenge. This review is bound to give insight into the current scientific research being conducted to render BC degradable for biomedical applications. The data has been collected through Clarivate analysis, Google search, PubMed Central Identifier (PMCID), and Research Gate. The lack of available literature on this topic allowed us to include all the articles related to the subject as old as 1988 onwards.

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Ionic liquid transdermal delivery system: Progress, prospects, and challenges

Cited by 38 publications

References 222 publications

Transformation of Hydrophilic Drug into Oil-Miscible Ionic Liquids for Transdermal Drug Delivery

Transformation of Hydrophilic Drug into Oil-Miscible Ionic Liquids for Transdermal Drug Delivery

An overview of biomedical applications of choline geranate (CAGE): a major breakthrough in drug delivery

Ionic Liquid Based Treatment – A Potential Strategy to Modify Bacterial Cellulose

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