Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions

Abstract

We report a novel ionic liquid (IL)-mediated transcutaneous vaccine formulation consisting of a solid-in-oil nanodispersion of antigen coated with pharmaceutically accepted surfactants dispersed in IL-containing oil. The introduction of IL in the formulation significantly enhanced the skin permeability of ovalbumin, a model antigen.

Ionic liquids for the preparation of biopolymer materials for drug/gene delivery: a review

“…Surfactant IL-DNA complexes can particularly favour transdermal drug delivery, since the surfactant ILs may act as a penetration enhancer to improve skin-permeating ability, which is the main limit of the efficiency of transdermal DDSs. 49 For instance, therapeutic RNA robed with IL moieties (benzyl dimethyl octyl ammonium (BDOA)) was exploited as a simple, scalable prodrug platform to treat skin disease. 234 The skin transport of this therapeutic RNA was significantly enhanced by robing with BDOA, with a higher applied dose delivered into the viable epidermis (9.85 ± 2.64%) compared to only 2.06 ± 0.15% for naked RNA.…”

“…Moreover, some new applications such as pharmaceutical ILs are emerging. 47 Being very effective at dissolving many types of biologically active compounds (e.g., proteins, nucleosides, and amino acids) 32,48 and the formation of drug/gene delivery carriers, 49 ILs are considered highly useful for the pharmaceutical industry. In recent years, there have been several reviews documenting the advances in using ILs for pharmaceuticals, 47 the application of ILs for biodegradable composite materials, 50 or chitin and chitosan materials for biomedical applications.…”

Ionic liquids for addressing unmet needs in healthcare

“…The IL/water microemulsion formulation permits the efficient transport of etodolac into the skin, resulting in a comparatively more effective therapeutic performance compared to formulations without ILs. In a recent development, the Goto group applied a 1‐dodecyl‐3‐methylimidazolium‐based IL to enhance the skin permeability of a solid‐in‐oil nanodispersion to deliver ovalbumin in vitro …”

Long Periodic Structure of a Room‐Temperature Ionic Liquid by High‐Pressure Small‐Angle X‐Ray Scattering and Wide‐Angle X‐Ray Scattering: 1‐Decyl‐3‐Methylimidazolium Chloride

“…Room‐temperature ionic liquids (RTILs) have been utilized in green chemistry, electrochemical devices, biosciences, and so on. In addition to the excellent properties of 1‐alkyl‐3‐methylimidazolium nitrate [C n mim][NO 3 ] ( n =1, 2, 3, 4, 6, and 8) RTILs (where n indicates the alkyl side‐chain length) that were found using molecular dynamics (MD) simulations, spatial nano‐heterogeneity can be predicted based on the effect of the alkyl side‐chain length of the cation .…”