Ionic Liquid–Liquid Chromatography: A New General Purpose Separation Methodology

Abstract

Ionic liquids can form biphasic solvent systems with many organic solvents and water, and these solvent systems can be used in liquid-liquid separations and countercurrent chromatography. The wide range of ionic liquids that can by synthesised, with specifically tailored properties, represents a new philosophy for the separation of organic, inorganic and bio-based materials. A customised countercurrent chromatograph has been designed and constructed specifically to allow the more viscous character of ionic liquid-based solvent systems to be used in a wide variety of separations (including transition metal salts, arenes, alkenes, alkanes, bio-oils and sugars).

Ionic liquid‐modified countercurrent chromatographic isolation of high‐purity delphinidin‐3‐rutinoside from eggplant peel

“…Systems of MTBE–butanol–acetonitrile–1% TFA water–[C 4 MIM][PF 6 ] (2:4:1:5: x , v/v/v/v/v) were further optimized for the amount of IL. As can be seen from Table 3, relative hydrophobic [C 4 MIM][PF 6 ] improves the solubility of polar compounds in the upper phase (Brown et al., 2017), which leads to a dose‐dependent rise of K ‐values of compound 1 and compound 3 in the biphasic solvent system. With increasing amount of IL, the α 1 ( K 1 / K 3 ) value increased gradually reaching a maximum at x = 0.2 and then decreased slightly.…”

“…And their properties can be effectively tuned by random combination of abundant cations and anions. Thus, ILs are described as “designer solvents,” as they can be engineered to tackle specific problems, for example, producing multiphasic solvent systems to improve separation efficiency or allow simplified separations (Brown, Earle, Gilea, Plechkova, & Seddon, 2017; Lei, Chen, Koo, & MacFarlane, 2017). According to this, ILs could be a suitable candidate for isolation anthocyanins from food resources and waste.…”

Analytical techniques for Nizatidine: A review

“…Ionic liquid can form biphasic solvent systems with many organic solvents and water, and these systems can be used in liquid‐liquid separation, counter current chromatography . Extraction process for Nizatidine, was done by taking 1 mL ionic liquid i.e., 1‐butyl‐3‐methylimidazolium hexa fluoro phosphate and was transferred into a 10 mL centrifuge tube.…”

Improved ionic-liquid-functionalized macroporous supports able to purify nucleic acids in one step

“…ILs are salts, usually described as liquid salts below 100 °C, which can be tailored in terms of their properties, such as polarity, density, viscosity, conductivity, among others [ 17 , 18 ]. ILs have been used in liquid chromatography in distinct ways [ 19 , 20 ]: as additives of mobile phases [ 21 ], as ligands of stationary phases [ 22 , 23 ], or acting themselves as stationary phases [ 24 ]. In most of these works, it was demonstrated the high performance of ILs achieved by the effective design of their chemical structures.…”