Ionic Liquid: A Green Solvent for Organic Transformations II

Chen, Shui‐Ling; Chua, Guan‐Leong; Ji, Shun‐Jun; Loh, Teck Peng

doi:10.1021/bk-2007-0950.ch014

Cited by 6 publications

(7 citation statements)

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“…The DIPEAc medium was the best promoter for the preparation of dihydrothiophene derivatives; reasons for this could be explained as follows: (1) the use of DIPEAc raises the solubility of reagents, which results to a higher interfacial area and lower mass transfer resistance . (2) The promoting impact of DIPEAc to the reaction could be credited to its hydrophobic, polarity, and hydrogen-bonding effects , (Scheme ), making it easy to develop related products. It was revealed that only polar protic solvents could give the expected outcome, and the hydrogen-bonding effect is the main difference between other solvents and polar protic solvents, so the hydrogen-bonding effect may be the key factor to facilitate the reaction.…”

Section: Resultsmentioning

confidence: 99%

Rapid Construction of Substituted Dihydrothiophene Ureidoformamides at Room Temperature Using Diisopropyl Ethyl Ammonium Acetate: A Green Perspective

et al. 2020

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An economic, sustainable, and straightforward environmentally friendly synthesis of highly diversified polyfunctional dihydrothiophenes is successfully achieved via diisopropyl ethyl ammonium acetate as a room-temperature ionic liquid. Multicomponent synthesis contains domino processes; the benefit of this present protocol is highlighted by its readily available starting materials, superior functional group tolerance, purity of synthesized compounds was checked by high-performance liquid chromatography results in up to 99.7% purity for the synthesized compounds, reaction mass efficiency, effective mass yield, and excellent atom economy. In addition, a series of 2-(N-carbamoyl acetamide)-substituted 2,3-dihydrothiophene analogs were synthesized, and selected samples were chosen for testing their in vitro antibacterial and antifungal activities. Furthermore, a molecular docking study against sterol 14α-demethylase could provide valuable insight into the mechanism of antifungal action providing an opportunity for structure-based lead optimization.

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Section: Resultsmentioning

confidence: 99%

Rapid Construction of Substituted Dihydrothiophene Ureidoformamides at Room Temperature Using Diisopropyl Ethyl Ammonium Acetate: A Green Perspective

et al. 2020

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“…Ionic liquids typically consist of organic cations and organic or inorganic anions and are classified accordingly [139]. They exhibit several useful features such as good solubility, high ionic conductivity, reusability, and possess good thermal stability (see Tables 7, 8) [140]. Depending on the anions, cations and alkyl group composition of ionic liquids, their properties vary and their efficiency/effectiveness are altered accordingly.…”

Section: Ionic Liquids Application For Eormentioning

confidence: 99%

An overview of chemical enhanced oil recovery: recent advances and prospects

et al. 2019

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Despite the progress made on renewable energy, oil and gas remains the world's primary energy source. Meanwhile, large amounts of oil deposits remain unrecovered after application of traditional oil recovery methods. Chemical enhanced oil recovery (EOR) has been adjudged as an efficient oil recovery technique to recover bypassed oil and residual oil trapped in the reservoir. This EOR method relies on the injection of chemicals to boost oil recovery. In this overview, an up-to-date synopsis of chemical EOR with detailed explanation of the chemicals used, and the mechanism governing their oil recovery application have been discussed. Challenges encountered in the application of the various conventional chemical EOR methods were highlighted, and solutions to overcome the challenges were proffered. Besides, the recent trend of incorporating nanotechnology and their synergistic effects on conventional chemicals stability and efficiency for EOR were also explored and analysed. Finally, laboratory results and field projects were outlined. The review of experimental studies shows that porescale mechanisms of conventional chemical EOR is enhanced by incorporating nanotechnology, hence, resulted in higher efficiency. Moreover, the use of ionic liquid chemicals and novel alkaline-cosolvent-polymer technology shows good potentials. This overview presents an extensive information about chemical EOR applications for sustainable energy production.

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“…Several cardiovascular agents with polyhydroquinoline structural scaffolds are outlined in Figure . Molecules with polyhydroquinoline structural scaffolds possess a broad spectrum of biological and pharmacological activities such as antidiabetic, hepatoprotective, vasodilator, geroprotective, antiatherosclerotic, bronchodilator, anticancer, and antitumor activities . These important and valuable activities have encouraged chemists to design new, green, economical and efficient catalytic systems for the synthesis of molecules with polyhydroquinoline structural scaffolds.…”

Section: Introductionmentioning

confidence: 99%

“…Molecules with polyhydroquinoline structural scaffolds possess a broad spectrum of biological and pharmacological activities such as antidiabetic, hepatoprotective, vasodilator, geroprotective, antiatherosclerotic, bronchodilator, anticancer, and antitumor activities. [35][36][37][38][39][40][41] These important and valuable activities have encouraged chemists to design new, green, economical and efficient catalytic systems for the synthesis of molecules with polyhydroquinoline structural scaffolds. Recently, a large number of protocols for the synthesis of this class of N-containing heterocyclic molecules have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Magnetically Recoverable Catalysts: Catalysis in Synthesis of Polyhydroquinolines

Kazemi

Mohammadi

2019

Applied Organom Chemis

157

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Molecules that contain polyhydroquinoline structural scaffolds are N‐containing heterocycles which are of great interest to organic chemists and biologists. Polyhydroquinoline structural scaffolds which are known as calcium channel blockers have emerged as one of the most important class of drugs used for the treatment of cardiovascular and Alzheimer's diseases. Besides, recovery and reusability of catalysts are important issues to be discussed in modern catalysis research especially in organic synthesis. The concept of magnetically recoverable catalysts has been rapidly developed in recent times. Magnetic separation is an efficient strategy for the rapid separation of catalysts from the reaction medium. Also, an alternative to time‐, solvent‐, and energy‐consuming separation techniques. In this review, we focused on the fabrication, surface‐modification and characterization of nanomagnetic materials and their application, as magnetically recoverable catalysts, in the synthesis of polyhydroquinoline structural scaffolds.

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Ionic Liquid: A Green Solvent for Organic Transformations II

Cited by 6 publications

References 0 publications

Rapid Construction of Substituted Dihydrothiophene Ureidoformamides at Room Temperature Using Diisopropyl Ethyl Ammonium Acetate: A Green Perspective

Rapid Construction of Substituted Dihydrothiophene Ureidoformamides at Room Temperature Using Diisopropyl Ethyl Ammonium Acetate: A Green Perspective

An overview of chemical enhanced oil recovery: recent advances and prospects

Magnetically Recoverable Catalysts: Catalysis in Synthesis of Polyhydroquinolines

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