Ion-trap multiple mass spectrometry in pesticide analysis

Larsen, B.

doi:10.1051/analusis:2000280941

Cited by 14 publications

(10 citation statements)

References 15 publications

(26 reference statements)

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“…In the case of chlorotriazines, a characteristic product ion at m/z 110 is also formed from the ion at m/z 146 through the neutral loss of HCl (Fig. ), as already described in the literature . This pathway is more favored in the chloro‐ rather than hydroxyl derivatives presumably because the HCl is a better leaving group than water; hence the low abundance of the corresponding ion at m/z 110 in the MS/MS spectra of hydroxytriazines.…”

Section: Resultsmentioning

confidence: 52%

Use of liquid chromatography/electrospray ionization tandem mass spectrometry to study the degradation pathways of terbuthylazine (TER) by Typha latifolia in constructed wetlands: identification of a new TER metabolite

Gikas

Papadopoulos

Bazoti

et al. 2011

Rapid Comm Mass Spectrometry

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S-Triazines are used worldwide as herbicides for agricultural and non-agricultural purposes. Although terbuthylazine (TER) is the second most frequently used S-triazine, there is limited information on its metabolism. For this reason, an analytical method based on liquid chromatography/electrospray ionization tandem mass spectrometry (LC-ESI MS/MS) has been developed aiming at the identification of TER and its five major metabolites (desisopropyl-hydroxy-atrazine, desethyl-hydroxy-terbuthylazine, desisopropyl-atrazine, hydroxy-terbuthylazine and desethyl-terbuthylazine) in constructed wetland water samples. The separation of TER and its major metabolites was performed by reversed-phase high-performance liquid chromatography (HPLC) on a C(8) column using a gradient elution of aqueous acetic acid 1% (solvent A) and acetonitrile (solvent B), followed by MS/MS analysis on a triple quadrupole mass spectrometer. The data-depended analysis (DDA) scan approach has been employed and the main degradation pathways of both hydroxyl and chloro (dealkylated and alkylated) metabolites are elucidated through the tandem mass spectral (MS/MS) interpretation of triazine fragments under CID conditions. In addition, another major metabolite of TER, namely N2-tert-butyl-N4-ethyl-6-methoxy-1,3,5-triazine-2,4-diamine, has been identified. This methodology can be further employed in biodegradation studies of TER, thus assisting the assessment of its environmental impact.

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Section: Resultsmentioning

confidence: 52%

Use of liquid chromatography/electrospray ionization tandem mass spectrometry to study the degradation pathways of terbuthylazine (TER) by Typha latifolia in constructed wetlands: identification of a new TER metabolite

Gikas

Papadopoulos

Bazoti

et al. 2011

Rapid Comm Mass Spectrometry

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“…Blasco et al, 2003 showed that ophenylphenol, which remains intact in the collision cell of the triple quadrupole [118], is easily fragmented in QIT to provide a major ion fragment at m/z 141. However, different authors reported that phenoxyacid or ammonium quaternary herbicides displayed the same MS 2 spectrum with QIT and TQ [26,35,49,119,120].…”

Section: Pesticides and Transformation Products (Tps)mentioning

confidence: 99%

“…A good example is the formation of the ion at m/z 174-the base peak from triazine. That ion derives by migration of a hydrogen atom from the methyl group in the γ -position to the positively charged amino group to lead to the loss of a disubstituted ethylene molecule [26,35,39]. (Fig.…”

Section: Pesticides and Transformation Products (Tps)mentioning

confidence: 99%

“…The power of this technology is that it provides structural information for identifying non-target contaminants (unknown compounds), increases the specificity of target-analytes identification, since there is not questionability on the precursor of the fragment in the product ion spectrum, and achieves high sensitive trace-level determination [4,26].…”

Section: Introductionmentioning

confidence: 99%

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Liquid Chromatography-Ion Trap-Mass Spectrometry and its Application to Determine Organic Contaminants in the Environment and Food

Andreu¹,

Picó

2005

CAC

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Recent experiences with liquid chromatography-quadrupole ion trap-mass spectrometry (LC-QIT-MS), as an analytical tool for determining trace amounts of organic contaminants in food and environmental samples, are addressed in this review. A brief introduction to the fundamental theory for quadrupole ion trap devices illustrates possibilities and limitations of this technique. Special attention is paid to the impact of sample preparation and chromatography on the ionization efficiency of analytes isolated from complex food and environmental matrices. The capacity to provide useful data for quantifying organic contaminants, and the possibility of obtaining structural information for identifying target and non-target compounds, are discussed. The flexibility, high sensitivity and multi-stage tandem mass spectrometric capability of the QIT are all illustrated. Contemporary applications of this technique to study organic contaminants in food and environment are presented.

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“…In spite of this, MS 2 and MS n libraries have been set up, showing identical fragmentation pathways in GC-CI-MS/MS and LC-API-MS/MS [47,48,49]. Fragmentation of pesticide molecules after soft-ionization have been widely studied [45,50,51,52]. Selected pesticide MS n fragmentation pathways are shown in table 6.…”

Section: Mass Spectrometry As Lc Detectormentioning

confidence: 99%

Liquid Chromatography Tandem Mass Spectrometry as a Tool to Investigate Pesticides and Their Degradation Products

Medana¹,

Calza²,

Baiocchi³

et al. 2005

COC

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The analytical determination of organic structures is a fundamental need in environmental, food and medicinal chemistry, and the chemistry of pesticide compounds is closely involved in this determination because of the environmental and biological transformations that can occur to these molecules. Degradation products often possess higher toxicity than parent substances but unknown structures, and aqueous milieu produce hard-to-solve instrumental problems. The need to analyze low concentrations in polar solutions means that methods in which liquid chromatography is hyphenated to mass spectrometry have a large playing field, which combines trace determination and structural elucidation. An important area of study comprises degradation-simulating models, such as titanium dioxide mediated photocatalytic attacks on different organic structures. HPLC-mass spectrometric studies on pesticides, their metabolites and their degradation products are reviewed.

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Ion-trap multiple mass spectrometry in pesticide analysis

Cited by 14 publications

References 15 publications

Use of liquid chromatography/electrospray ionization tandem mass spectrometry to study the degradation pathways of terbuthylazine (TER) by Typha latifolia in constructed wetlands: identification of a new TER metabolite

Use of liquid chromatography/electrospray ionization tandem mass spectrometry to study the degradation pathways of terbuthylazine (TER) by Typha latifolia in constructed wetlands: identification of a new TER metabolite

Liquid Chromatography-Ion Trap-Mass Spectrometry and its Application to Determine Organic Contaminants in the Environment and Food

Liquid Chromatography Tandem Mass Spectrometry as a Tool to Investigate Pesticides and Their Degradation Products

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