Ion–solvent interaction of tetraalkylammonium ions in solvents of high dielectric constant. Part I. Conductance and Walden product of tetraalkylammonium ions in N-methylacetamide at different temperatures

Singh, Ravender; Rastogi, Pushti Prakash; Gopal, Ram

doi:10.1139/v68-584

Cited by 43 publications

(8 citation statements)

References 10 publications

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“…The higher Λ 0 value of SMV can be ascribed to the similar point of analogy as in the case of the molar conductivities. 27 It is evident from Table 3 that Λ 0 of SMV increases with an increase in temperature in the aqueous solutions of ARG. A similar trend is seen in the case of the ARG solutions only ( Table 2 ).…”

Section: Resultsmentioning

confidence: 90%

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Affandi¹,

Tripathy²,

Majeed³

2016

DDDT

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We examined the solubility of simvastatin in water in 0.01 mol·dm−3, 0.02 mol·dm−3, 0.04 mol·dm−3, 0.09 mol·dm−3, 0.18 mol·dm−3, 0.36 mol·dm−3, and 0.73 mol·dm−3 arginine (ARG) solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies illustrated a higher extent of solubility enhancement for simvastatin. The aforementioned system was subjected to conductometric and volumetric measurements at temperatures (T) of 298.15 K, 303.15 K, 308.15 K, and 313.15 K to illustrate the thermodynamics involved and related solute–solvent interactions. The conductance values were used to evaluate the limiting molar conductance and association constants. Thermodynamic parameters (ΔG0, ΔH0, ΔS0, and Es) for the association process of the solute in the aqueous solutions of ARG were calculated. Limiting partial molar volumes and expansibilities were evaluated from the density values. These values are discussed in terms of the solute–solvent and solute–cosolute interactions. Further, these systems were analyzed using ultraviolet–visible analysis, Fourier-transform infrared spectroscopy, and 13C, 1H, and two-dimensional nuclear overhauser effect spectroscopy nuclear magnetic resonance to complement thermophysical explanation.

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Section: Resultsmentioning

confidence: 90%

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Affandi¹,

Tripathy²,

Majeed³

2016

DDDT

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“…The higher Λ 0 value of ATV can be attributed to the similar point of analogy as in the case of the molar conductance. [ 25 ] It can be seen from Tables 1 and 2 that Λ 0 of ATV and aqueous ARG solution increases with a rise in temperature which indicates less solvation or higher mobility of ions. In addition, an increased in thermal energy results in greater bond breaking and variation in vibrational, rotational, and translational energy of the molecules that leads to higher frequency and higher mobility of the ions.…”

Section: Resultsmentioning

confidence: 99%

Conductometric and volumetric studies of atorvastatin in aqueous solution of arginine from 298.15 to 313.15 K

Affandi

Tripathy

Majeed

2016

J Adv Pharm Technol Res

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Categorized as a Biopharmaceutics Classification System Class II drugs, atorvastatin (ATV) exhibits low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. Numerous studies are available in regard to the solubility enhancement of ATV, but very few actually describe this phenomenon in terms of thermodynamics and the solute-solvent interaction. Arginine (ARG) is an amino acid that has been reported to enhance the solubility of the highly insoluble wheat protein gluten through hydrogen bonding and π electron-cation interaction. To our knowledge, ARG has never been investigated as a solubility enhancement agent of aqueous insoluble drugs. Thus, this study aimed to elucidate the solute-solvent and solute-cosolute interactions and derive thermodynamic parameters that bolstered the solubility of ATV in the presence of ARG. We examined the electrolytic conductance and densities of ATV-ARG binary system covering the temperature ranging from 298.15 K to 313.15 K. Conductometric and volumetric parameters such as limiting molar conductance, association constants, limiting partial molar volumes, and expansibility values were calculated. Additionally, thermodynamic parameters (ΔG0, ΔH0, ΔS0, and Es) involved in the association process of the solute in the aqueous solution of ARG were also determined.

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“…The values of limiting molar conductance Λ 0 (S cm 2 mol -1 ), association constant, K A , (dm 3 mol -1 ) and Walden product Λ 0 η 0 , (Wod = without drug; Wd = with drug) As observed, the values of Λ 0 of nimesulide in aqueous solutions of hydrotropic agents are very low. This is due to the fact that the hydrodynamic radii of the ions (generated from the hydrotropic agents) increase in the presence of nimesulide in the solution which causes a decrease in their mobility 13 .…”

Section: Resultsmentioning

confidence: 99%

Conductometric Study of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures

Solanki¹,

Mishra²,

Talari

et al. 2010

Journal of Chemistry

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Conductance values of nimesulide have been determined in water in 0.1, 0.2, 0.4, 0.6, 0.8, 1 and 2 mol dm-3aqueous solutions of hydrotropic agents (sodium benzoate, sodium salicylate, sodium bromide and nicotinamide) at temperatures 298.15, 303.15, 308.15 and 313.15 K. The conductance values have been used to evaluate the limiting molar conductance and association constants by means of Shedlovsky extrapolation technique. Thermodynamic parameters for the association process of nimesulide in aqueous solutions of hydrotropic agents have also been calculated.

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Ion–solvent interaction of tetraalkylammonium ions in solvents of high dielectric constant. Part I. Conductance and Walden product of tetraalkylammonium ions in N-methylacetamide at different temperatures

Cited by 43 publications

References 10 publications

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Conductometric and volumetric studies of atorvastatin in aqueous solution of arginine from 298.15 to 313.15 K

Conductometric Study of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures

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Ion–solvent interaction of tetraalkylammonium ions in solvents of high dielectric constant. Part I. Conductance and Walden product of tetraalkylammonium ions in N-methylacetamide at different temperatures

Cited by 43 publications

References 10 publications

Solubility enhancement of simvastatin by arginine: thermodynamics, solute&ndash;solvent interactions, and spectral analysis

Solubility enhancement of simvastatin by arginine: thermodynamics, solute&ndash;solvent interactions, and spectral analysis

Conductometric and volumetric studies of atorvastatin in aqueous solution of arginine from 298.15 to 313.15 K

Conductometric Study of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures

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Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis