Ion size, loading, and charge determine the mechanical properties, surface apatite, and cell growth of silver and tantalum doped calcium silicate

Shirazi, Seyed Farid Seyed; Gharehkhani, Samira; Metselaar, Hendrik Simon Cornelis; Yarmand, Hooman; Ahmadi, Mahdi; Osman, Noor Azuan Abu

doi:10.1039/c5ra17326d

Cited by 25 publications

(5 citation statements)

References 56 publications

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“…The mechanical strength of dense DCSC disks is primarily determined by their sintering kinetics and densification profile, both of which are affected by the stoichiometric formula of the ceramic, the presence of dopant oxides, and the resulting atomic or ionic interactions. Similar relations have been observed for β-TCP scaffolds [ 53 , 54 , 55 , 56 ] and other ceramics [ 57 , 58 , 59 ] containing various oxide dopants. As shown in Table 2 , all dense DCSCs (except hardystonite) had lower porosity compared to α-CS (15.5%) and β-CS (18.6%), indicating enhanced densification in DCSCs which is a key contributor to their improved mechanical strength.…”

Section: Mechanical Properties Of Solid and Porous Dcscssupporting

confidence: 83%

“…Similar relations have been observed for β-TCP scaffolds [53,54,55,56] and other ceramics [57,58,59] containing various oxide dopants. As shown in Table 2, all dense DCSCs (except hardystonite) had lower porosity compared to α-CS (15.5%) and β-CS (18.6%), indicating enhanced densification in DCSCs which is a key contributor to their improved mechanical strength.…”

Section: Mechanical Properties Of Solid and Porous Dcscssupporting

confidence: 82%

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Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Zreiqat

2017

Materials

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Doped calcium silicate ceramics (DCSCs) have recently gained immense interest as a new class of candidates for the treatment of bone defects. Although calcium phosphates and bioactive glasses have remained the mainstream of ceramic bone substitutes, their clinical use is limited by suboptimal mechanical properties. DCSCs are a class of calcium silicate ceramics which are developed through the ionic substitution of calcium ions, the incorporation of metal oxides into the base binary xCaO–ySiO2 system, or a combination of both. Due to their unique compositions and ability to release bioactive ions, DCSCs exhibit enhanced mechanical and biological properties. Such characteristics offer significant advantages over existing ceramic bone substitutes, and underline the future potential of adopting DCSCs for clinical use in bone reconstruction to produce improved outcomes. This review will discuss the effects of different dopant elements and oxides on the characteristics of DCSCs for applications in bone repair, including mechanical properties, degradation and ion release characteristics, radiopacity, and biological activity (in vitro and in vivo). Recent advances in the development of DCSCs for broader clinical applications will also be discussed, including DCSC composites, coated DCSC scaffolds and DCSC-coated metal implants.

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Section: Mechanical Properties Of Solid and Porous Dcscssupporting

confidence: 83%

Section: Mechanical Properties Of Solid and Porous Dcscssupporting

confidence: 82%

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Zreiqat

2017

Materials

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“…Still the data showed that different kinds of charged surfaces led to obviously different cell morphology. So, the electric properties of the materials, including the types and densities, have great influence on the cell adhesion behavior (Shirazi et al, 2016; Kuo and Rajesh, 2017).…”

Section: The Influencing Factors Of Biocompatibility Of Aliphatic Polmentioning

confidence: 99%

Surface Modification of Aliphatic Polyester to Enhance Biocompatibility

Bei

et al. 2019

Front. Bioeng. Biotechnol.

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Aliphatic polyester is a kind of biodegradable implantable polymers, which shows promise as scaffolds in tissue engineering, drug carrier, medical device, and so on. To further improve its biocompatibility and cell affinity, many techniques have been used to modify the surface of the polyester. In the present paper, the key factors of influencing biocompatibility of aliphatic polyester were illuminated, and the different surface modification methods such as physical, chemical, and plasma processing methods were also demonstrated. The advantages and disadvantages of each method were also discussed with the hope that this review can serve as a resource for selection of surface modification of aliphatic products.

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“…However, insertion of implants to replace the injured parts often gives discomfort to patients, due to the brittleness and insufficient biological properties of the bioceramic implants [5]. Therefore, many attempts have been made to improve the functional specifications of ceramic implants and to regenerate old and deteriorating bones with a biomaterial that can be substituted by a new mature bone without transient loss of a mechanical support [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Structural insights of mechanically induced aluminum-doped hydroxyapatite nanoparticles by Rietveld refinement

Fahami

Beall

Basirun

2017

Chinese Journal of Chemical Engineering

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Aluminum doped hydroxyapatite (HA:Al 3+) nanopowders were successfully prepared via a simple and efficient one-pot mechanochemical route. The effects of dopant loading on phase compositions and structural features were assessed by Rietveld analysis. The XRD-Rietveld refinement revealed the stabilization of HA in hexagonal structure for all the samples. The sharpness and intensity of the apatite-derived XRD peaks decreased as the dopant content increased to 10% due to the increase in lattice imperfections and mechanically induced amorphization. The incorporation of Al 3+ into the HA lattice decreased the unit cell parameters. From the FTIR measurements, the representing bands of apatite were identified in all cases. The mechanosynthesized nanopowders consisted of nanospheroids with an average size of 44±20 nm and therefore are promising for bone tissue regeneration.

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Ion size, loading, and charge determine the mechanical properties, surface apatite, and cell growth of silver and tantalum doped calcium silicate

Abstract: This study describes how various loadings of two ions with different size and charge, such as silver and tantalum, can affect the mechanical and biological properties of calcium silicate (CS).

Cited by 25 publications

References 56 publications

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Surface Modification of Aliphatic Polyester to Enhance Biocompatibility

Structural insights of mechanically induced aluminum-doped hydroxyapatite nanoparticles by Rietveld refinement

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