Ion-selective electrodes based on l-tryptophan and l-tyrosine

Moriuchi‐Kawakami, Takayo; Tokunaga, Yu; Yamamoto, Hiroyuki; Shibutani, Yasuhiko

doi:10.1016/j.talanta.2012.02.065

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Among the types of sensors that can be conceived as point-of-care tools, ion-selective electrodes (ISEs) have attracted increasing attention over the past years owing to simplicity, versatility, rapid responsiveness, cost-effectiveness, miniaturization, and user-friendly nature. − ISEs are able to monitor minor fluctuations in ion concentrations (strictly speaking, fluctuations in ion activity) related to ongoing processes in diverse samples, such as biological fluids and environmental water among others. , Accordingly, changes found in ion concentration may be indicative of significant processes occurred in the traced event, of which their interpretation offers valuable information in terms of body status, illness diagnosis, contamination, and so on. − This information becomes exceptionally relevant when it is attained in situ and in real time, as is the case with point-of-care devices.…”

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confidence: 99%

Cytotoxicity Study of Ionophore-Based Membranes: Toward On-Body and in Vivo Ion Sensing

et al. 2019

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We present the most complete study to date comprising in vitro cytotoxicity tests of ion-selective membranes (ISMs) in terms of cell viability, proliferation, and adhesion assays with human dermal fibroblasts. ISMs were prepared with different types of plasticizers and ionophores to be tested in combination with assays that focus on the medium-term and long-term leaching of compounds. Furthermore, the ISMs were prepared in different configurations considering (i) innerfilling solution-type electrodes, (ii) all-solid-state electrodes based on a conventional drop-cast of the membrane, (iii) peeling after the preparation of a wearable sensor, and (iv) detachment from a microneedle-based sensor, thus covering a wide range of membrane shapes. One of the aims of this study, other than the demonstration of the biocompatibility of various ISMs and materials tested herein, is to create an awareness in the scientific community surrounding the need to perform biocompatibility assays during the very first steps of any sensor development with an intended biomedical application. This will foster meeting the requirements for subsequent on-body application of the sensor and avoiding further problems during massive validations toward the final in vivo use and commercialization of such devices.

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confidence: 99%

Cytotoxicity Study of Ionophore-Based Membranes: Toward On-Body and in Vivo Ion Sensing

et al. 2019

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“…In order to overcome size limitation, exciting efforts are currently underway to create miniaturized ISMs, and arrays of ISMs, by harnessing microfluidics technology (reviewed in reference [58]). Furthermore, ion-selective cocktails with novel and improved characteristics and ion-selectivities are constantly in development (e.g., [59–61] and review of ion-selective electrodes based on PVC-membranes that could be incorporated into ISMs in reference [62]), broadening the range of studies to which ISMs can be applied.…”

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confidence: 99%

Monitoring Ion Activities In and Around Cells Using Ion-Selective Liquid-Membrane Microelectrodes

Lee

Boron

Parker

2013

Sensors

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Determining the effective concentration (i.e., activity) of ions in and around living cells is important to our understanding of the contribution of those ions to cellular function. Moreover, monitoring changes in ion activities in and around cells is informative about the actions of the transporters and/or channels operating in the cell membrane. The activity of an ion can be measured using a glass microelectrode that includes in its tip a liquid-membrane doped with an ion-selective ionophore. Because these electrodes can be fabricated with tip diameters that are less than 1 μm, they can be used to impale single cells in order to monitor the activities of intracellular ions. This review summarizes the history, theory, and practice of ion-selective microelectrode use and brings together a number of classic and recent examples of their usefulness in the realm of physiological study.

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Modified Screen-Printed Electrode for Potentiometric Determination of Copper(II) in Water Samples

et al. 2013

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Ion-selective electrodes based on l-tryptophan and l-tyrosine

Cited by 6 publications

References 24 publications

Cytotoxicity Study of Ionophore-Based Membranes: Toward On-Body and in Vivo Ion Sensing

Cytotoxicity Study of Ionophore-Based Membranes: Toward On-Body and in Vivo Ion Sensing

Monitoring Ion Activities In and Around Cells Using Ion-Selective Liquid-Membrane Microelectrodes

Modified Screen-Printed Electrode for Potentiometric Determination of Copper(II) in Water Samples

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