Ion-selective electrode for the determination of trazodone in tablets

Abstract

A coated wire trazodone-selective electrode based on incorporation of trazodone-tetraphenylborate ion pair in a poly(vinylchloride) coating membrane was constructed. The influences of membrane composition, temperature, pH of the test solution, and foreign ions on the electrode performance were investigated. The electrode showed a Nernstian response over a trazodone concentration range from 1.41 x 10(-5) to 0.89 x 10(-2) M, at 25 degrees C, and was found to be very selective, precise, and usable within the pH range 2.4-9.0. The standard electrode potentials, E degree, were determined at 20, 25, 30, 35, 40 and 45 degrees C and used to calculate the isothermal temperature coefficient (dE degree/dT) of the electrode. Temperatures higher than 45 degrees C seriously affected the electrode performance. The electrode was successfully used for potentiometric determination of trazodone hydrochloride both in pure solutions and in pharmaceutical preparations.

New colorimetric methods for the determination of trazodone HCl, famotidine, and diltiazem HCl in their pharmaceutical dosage forms

“…These methods are based on spectrophotometry [1,2,3], liquid chromatography [4,5], potentiometry [6], and an ion-selective electrode [3]. The methods used for trazodone are spectrophotometry and fluorimetry [7], liquid chromatography [8], ion-selective electrodes [9], and atomic absorption spectrometry [10]. The methods used for diltiazem are spectrophotometry [11], voltammetry [12], and liquid chromatography [13].…”

Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species

“…The official method for analysis of trazodone hydrochloride based on HPLC using octadecylsilane column and water-0.01 M ammonium phosphate buffer pH 6.0 (60: 40) as mobile phase 2 and potentiometric non-aqueous titration with perchloric acid 3 .The analytical methods that are reported for the determination of trazodonehydrochloride in pharmaceutical formulations include spectrophoto-metric methods [4][5][6][7] ion-selective electrodes 8,9 voltammetry [10][11][12][13] and various chromatographic methods including; HPLC 2,[14][15][16][17] capillary gas chromatography 18 , liquid chromatography-tandem mass spectrometry 19 and instrumental thin layer chromatography 20 . Also, spectrofluorimetric methods have been reported 21,22 .…”

Study of Co(AAOPD) and Cu(AAOPD) Schiff-Base Catalysts Effect in Oxidation Oximes and Carboxylic Acids Derivatives

“…German chemist (Hugo Schiff) was discovered these compounds and Schiff-Base or (-RC=N-) groups, after Hugo Schiff if related Imine from reaction of one Aldehyde with Amine type (I) was produced 1 , call it Aldimine and if related Imine from reaction of a cotton with amine type(I) and Ammonium produced call it ketamine 4 . They used widely in nano-technology 5,6 pharmaceutical fields 7,8 and as artificial receptors 9,10 for corrosion preventing 11 [30][31][32][33][34][35][36] . However in this research, oximes and carboxylic acids in various industrials were examined for Base-Promoted catalysts of Cu(AAOPD) and Co(AAOPD) on synthesis of some derivatives of these compounds.…”