Ion interaction chromatography of inorganic anions on a polystyrene-divinylbenzene adsorbent in the presence of tetraalkylammonium salts

Iskandarani, Ziad; Pietrzyk, Donald J.

doi:10.1021/ac00251a006

Cited by 64 publications

(30 citation statements)

References 27 publications

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“…Separation of inorganic anions on a poly(styrenedivinylbenzene) adsorbent in the presence of tetraalkylammonium salts [3]. Separation of inorganic anions on a poly(styrenedivinylbenzene) adsorbent in the presence of tetraalkylammonium salts [3].…”

Section: Principlesmentioning

confidence: 99%

Ion Pair Chromatography

Fritz

Gjerde²

2009

Ion Chromatography

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Section: Principlesmentioning

confidence: 99%

Ion Pair Chromatography

Fritz

Gjerde²

2009

Ion Chromatography

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“…Polystyrene (PS) is an amorphous and glassy polymer with highly ordered structures solely constructed by the polymerization of styrene. Owing to its strong covalent linkages between light elements (H and C), PS possesses many unique features such as low density, ease of handling, negligible solubility in water, nonbiodegradability, and nontoxicity, which make it applicable to diverse fields including wastewater treatment, − chromatographic separation, − solid-phase extraction, − and adsorption of proteins/peptides. − …”

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confidence: 99%

Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

et al. 2017

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Polystyrene (PS) is a class of polymer materials that offers great potential for various applications. However, the applications of PS microspheres in paper spray mass spectrometry are largely underexplored. Herein we prepared a series of PS microspheres via a simple dispersion polymerization and then used them as coating materials for paper spray mass spectrometry (MS) in high-sensitivity analysis of various therapeutic drugs in complex biological matrixes. In the preparation of PS-coated papers, the coating method was found playing a key role in determining the performance of the resulting paper substrate in addition to other parameters (e.g., starch type and amount, PS coating amount, and spray solvent). We also found that as a solvent was applied on PS-coated paper for paper spray, the analytes of interest would be first extracted out and then moved to the tip of paper triangle for spray along with the applied solvent. In the process, the surface energy of PS particles had a strong impact on the desorption performance of analytes from PS-coated paper substrate, and the PS with a high surface energy favored the elution of analytes to allow a high MS sensitivity. When the prepared PS coated paper was used as a substrate for paper spray, it gave high sensitivity in analysis of therapeutic drugs in various biological matrixes such as whole blood, serum, and urine with excellent repeatability and reproducibility. In contrast to uncoated filter paper, an improvement of 10-546-fold in sensitivity was achieved using PS-coated paper for paper spray, and an estimated lower limit of quantitation (LLOQs) in the range of 0.004-0.084 ng mL was obtained. The present study is significant in exploring the potential of PS for high-sensitivity MS analysis, and it provides a promising platform in the translation of the MS technique to clinical applications.

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“…For many years, micro-scale PS particles have found a wide variety of applications in many advanced materials and optical devices because of their homogeneous size, large surface area, negligible solubility in water, and invariant surface characteristics. [18][19][20][21] PS has also been extensively used as an adsorbent in the treatment of wastewater, [22][23][24][25][26] chromatographic separations, [27][28][29][30][31][32][33] solid-phase extraction, [34][35][36][37][38][39][40] and adsorption of proteins/peptides. [18][19][20][21][41][42][43][44][45] Although PS represents a powerful substrate that allows high efficiency treatment of various compounds in complex matrices, a complete analysis of its surface interactions is essential to further understand its performance and to develop improved materials.…”

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confidence: 99%

“…52 However, these techniques are essentially limited to exploring the molecular interaction modes at PS surfaces such as electrostatic interactions 43 and hydrophobic interactions, 53 and study the desorption behaviors of analytes on PS substrates. 30,32,33,49,[54][55][56][57][58][59] For the purpose of fully understanding the interactions between PS and adsorbed molecules, the adsorption and desorption of various compounds to the surfaces of PS particles have been widely analyzed, [60][61][62][63][64] but attention has been focused mainly on the reversible and irreversible adsorption mechanisms [61][62][63] or the effect of experimental parameters on adsorption interaction or performance. 60,64 There is little available quantitative experimental data on the correlation between adsorption and desorption behaviors of various analytes on PS substrates from different sources, which restricts greatly the understanding and interpretation of different molecular interactions on PS supports even composed of the same matrix.…”

mentioning

confidence: 99%