Ion-Excited Mechanically Active Self-Assembling Membranes for Rapid Wound Healing

Abstract

Biodegradable hydrogels or membranes show great application potential in wound healing of skin tissue in recent years because of their excellent biocompatibility and healing promotion. However, poor mechanical properties and single biological properties are the main challenges that traditional hydrogels or membranes need to overcome, while some other hydrogels or membranes with excellent mechanical properties are still limited by complicated preparation processes and high cost as well as poor biological safety. Here, a kind of Na + /Ca 2+ -inspired layer by layer self-assembly membrane (LBLSM) with controlled deformation is prepared through a simple method. LBLSM showed excellent antibacterial ability and mechanical properties under conditions of no matter drying, water or ethanol, which facilitated LBLSM to maintain a stable state in the face of more complicated treatments. More interestingly, the controlled deformation of LBLSM could be achieved and precisely regulated by Na + /Ca 2+ alternative treatment, which helped the regular diastole and contraction of the wound, further effectively activating cellular proliferation and promoting rapid wound healing. In conclusion, ion-excited LBLSM provides a good demonstration and inspiration for the application of mechanically active biomaterials in wound healing.

3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances

“…The most common therapeutic strategy for full-thickness skin defects is skin grafting or cell therapy for rapid wound closure . The severe damage or absence of wounds’ epithelialization demonstrates that dermal reconstruction is indispensable in wound healing . The tissue engineering approach could be a promising dermal regeneration and repair technique.…”

“…3 The severe damage or absence of wounds' epithelialization demonstrates that dermal reconstruction is indispensable in wound healing. 4 The tissue engineering approach could be a promising dermal regeneration and repair technique. At present, several products of tissue engineering are being used for skin defects.…”