Hydrogel-enabled mechanically active wound dressings

Chang, Le; Du, Huicong; Xu, Feng; Xu, Cuixiang; Liu, Hao

doi:10.1016/j.tibtech.2023.06.004

Cited by 8 publications

(6 citation statements)

References 78 publications

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“…Diabetes is characterized by chronic nonhealing wounds, which contribute to an increase in morbidity and mortality. , Numerous physiological and environmental factors can impede one or more stages of this intricate process, thereby resulting in failure of wound healing. For instance, the presence of elevated levels of proinflammatory cytokines, proteases, and reactive oxygen species (ROS) induces chronic inflammation in wounds such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers . Dysangiogenesis also severely slows wound healing, resulting in chronic nonhealing wounds.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the presence of elevated levels of proinflammatory cytokines, proteases, and reactive oxygen species (ROS) induces chronic inflammation in wounds such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers. 5 Dysangiogenesis also severely slows wound healing, resulting in chronic nonhealing wounds. The process of vascular network creation is an intricate and sequential phenomenon that entails the coordinated interaction of many cells, cytokines, and growth factors.…”

Section: Introductionmentioning

confidence: 99%

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Hybrid Self-Assembled Peptide Hydrogels Promote Skin Wound Healing in Diabetic Mice

Li,

Ma,

et al. 2024

ACS Appl. Polym. Mater.

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The treatment of diabetic wounds is highly important, as long-term nonclosure of chronic wounds is exceedingly painful for patients and can even lead to amputation. Inducing vascularization remains a significant challenge in diabetic wound healing. This article describes a hybrid peptide hydrogel based on pH-sensitive self-assembling and coassembling peptides. To repair tissue in diabetic wounds, Ac-FKFEFKFE-QHREDGS-NH2 (F–Q) and Ac-FKFEFKFE-GRGDS-NH2 (F–G) were hybridized to generate hydrogels. QHREDGS is derived from angiopoietin-1, whereas GRGDS is derived from osteopontin. Coassembly of F–Q and F–G yielded a bioactive hydrogel (F–Q/F–G) with the outstanding stability and the ability to stimulate endothelial cell growth, adhesion, and migration. The levels of CD31, bFGF, and VEGF in HUVECs exposed to the self-assembled functional peptide hydrogels were significantly greater than those in the control group, indicating that these factors could promote angiogenesis. When the F–Q or F–G hydrogel was applied to the skin defect region of diabetic rodents, angiogenesis and re-epithelialization were stimulated. In conclusion, these findings suggest that the F–Q/F–G hydrogel is a biomaterial with potential for promoting wound healing and vascular regeneration in the epidermis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hybrid Self-Assembled Peptide Hydrogels Promote Skin Wound Healing in Diabetic Mice

Li,

Ma,

et al. 2024

ACS Appl. Polym. Mater.

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“…Over the last few decades, there have been enormous developments in materials dedicated to medicine, particularly nanosized materials. Electrospun nanosized materials produced via electrospinning are investigated and applied in various biomedical fields, such as muscle and neural tissue [ 5 , 6 , 7 ], urology [ 8 , 9 ], drug delivery systems [ 10 , 11 , 12 ], regeneration [ 13 , 14 ], cartilage [ 15 ], anti-cancer treatment [ 16 ], and skin, especially wound dressings ( Figure 1 A) [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Over the last few decades, there have been enormous developments in materials dedicated to medicine, particularly nanosized materials. Electrospun nanosized materials produced via electrospinning are investigated and applied in various biomedical fields, such as muscle and neural tissue [5][6][7], urology [8,9], drug delivery systems [10][11][12], regeneration [13,14], cartilage [15], anti-cancer treatment [16], and skin, especially wound dressings (Figure 1A) [17][18][19]. Nanomaterials have unique features, such as a high surface-to-volume ratio, and innovative properties, such as hydrophobicity, morphology, or surface charge, that can be easily modified [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Antimicrobial Drug Delivery Systems and Hydrogels Used for Wound Dressings

Moazzami Goudarzi,

Zaszczyńska,

Kowalczyk

et al. 2024

Pharmaceutics

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Wounds and chronic wounds can be caused by bacterial infections and lead to discomfort in patients. To solve this problem, scientists are working to create modern wound dressings with antibacterial additives, mainly because traditional materials cannot meet the general requirements for complex wounds and cannot promote wound healing. This demand is met by material engineering, through which we can create electrospun wound dressings. Electrospun wound dressings, as well as those based on hydrogels with incorporated antibacterial compounds, can meet these requirements. This manuscript reviews recent materials used as wound dressings, discussing their formation, application, and functionalization. The focus is on presenting dressings based on electrospun materials and hydrogels. In contrast, recent advancements in wound care have highlighted the potential of thermoresponsive hydrogels as dynamic and antibacterial wound dressings. These hydrogels contain adaptable polymers that offer targeted drug delivery and show promise in managing various wound types while addressing bacterial infections. In this way, the article is intended to serve as a compendium of knowledge for researchers, medical practitioners, and biomaterials engineers, providing up-to-date information on the state of the art, possibilities of innovative solutions, and potential challenges in the area of materials used in dressings.

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“…Although nanoparticles (NPs) fabricated through self-assembly of antimicrobial peptides are believed to be compact structures, more efforts need to be spent on their longer stability during the local wound release. Wound dressing has been widely used for such purposes due to its facility and multiple functions, among which the hydrogel-based dressings have drawn increasing attention . By taking advantage of controlled delivery, hydrogels enable localized cargo release to avoid systemic drug administration.…”

Section: Introductionmentioning

confidence: 99%

Self-Adapting Biomass Hydrogel Embodied with miRNA Immunoregulation and Long-Term Bacterial Eradiation for Synergistic Chronic Wound Therapy

Wu,

Tang

et al. 2024

ACS Nano

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Chronic wound rescue is critical for diabetic patients but is challenging to achieve with a specific and long-term strategy. The prolonged bacterial inflammation is particularly prevalent in hyperglycemia-induced wounds, usually leading to severe tissue damage. Such a trend could further suffer from an environmental suitability provided by macrophages for persisting Staphylococcus aureus (S. aureus) and even deteriorate by their mutual reinforcement. However, the strategy of both suppressing bacteria growth and immunoreprogramming the inflammatory type of macrophages to break their vicious harm to wound healing is still lacking. Here, a selfadapting biomass carboxymethyl chitosan (CMC) hydrogel comprising immunomodulatory nanoparticles is reported to achieve Gram-negative/ Gram-positive bacteria elimination and anti-inflammatory cytokines induction to ameliorate the cutaneous microenvironment. Mechanistically, antibacterial peptides and CMCs synergistically result in a long-term inhibition against methicillin-resistant S. aureus (MRSA) over a period of 7 days, and miR-301a reprograms the M2 macrophage via the PTEN/PI3Kγ/mTOR signaling pathway, consequently mitigating inflammation and promoting angiogenesis for diabetic wound healing in rats. In this vein, immunoregulatory hydrogel is a promising all-biomass dressing ensuring biocompatibility, providing a perspective to regenerate cutaneous damaged tissue, and repairing chronic wounds on skin.

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Hydrogel-enabled mechanically active wound dressings

Cited by 8 publications

References 78 publications

Hybrid Self-Assembled Peptide Hydrogels Promote Skin Wound Healing in Diabetic Mice

Hybrid Self-Assembled Peptide Hydrogels Promote Skin Wound Healing in Diabetic Mice

Electrospun Antimicrobial Drug Delivery Systems and Hydrogels Used for Wound Dressings

Self-Adapting Biomass Hydrogel Embodied with miRNA Immunoregulation and Long-Term Bacterial Eradiation for Synergistic Chronic Wound Therapy

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