Ion Channels in Development and Cancer

Bates, Emily A.

doi:10.1146/annurev-cellbio-100814-125338

Cited by 179 publications

(176 citation statements)

References 94 publications

(123 reference statements)

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“…Thus, one possibility is that the observed double‐headed worm was induced by a reduced GMF‐mediated disruption of cytoskeletal signaling. Another important recent finding is that microgravity alters ion channel electrophysiology (Richard et al., ); as several studies have shown the importance of endogenous bioelectrical signaling in regenerative patterning in planaria (Beane et al., , ; Chan et al., ; Zhang, Chan, Nogi, & Marchant, ) and many other model systems (Bates, ; Levin, , ; Levin & Stevenson, ; Sundelacruz, Levin, & Kaplan, ), it is possible that some of our observed effects are mediated by alterations of ion channel function. Other possibilities include the effects of the space travel environment upon Wnt pathway molecules (Petersen & Reddien, ; Yazawa, Umesono, Hayashi, Tarui, & Agata, ) or physiological connectivity via gap junctions (Emmons‐Bell et al., ; Nogi & Levin, ; Oviedo et al., ).…”

Section: Discussionmentioning

confidence: 77%

Planarian regeneration in space: Persistent anatomical, behavioral, and bacteriological changes induced by space travel

et al. 2017

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Regeneration is regulated not only by chemical signals but also by physical processes, such as bioelectric gradients. How these may change in the absence of the normal gravitational and geomagnetic fields is largely unknown. Planarian flatworms were moved to the International Space Station for 5 weeks, immediately after removing their heads and tails. A control group in spring water remained on Earth. No manipulation of the planaria occurred while they were in orbit, and space‐exposed worms were returned to our laboratory for analysis. One animal out of 15 regenerated into a double‐headed phenotype—normally an extremely rare event. Remarkably, amputating this double‐headed worm again, in plain water, resulted again in the double‐headed phenotype. Moreover, even when tested 20 months after return to Earth, the space‐exposed worms displayed significant quantitative differences in behavior and microbiome composition. These observations may have implications for human and animal space travelers, but could also elucidate how microgravity and hypomagnetic environments could be used to trigger desired morphological, neurological, physiological, and bacteriomic changes for various regenerative and bioengineering applications.

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Section: Discussionmentioning

confidence: 77%

Planarian regeneration in space: Persistent anatomical, behavioral, and bacteriological changes induced by space travel

et al. 2017

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“…Addressing cancer from the perspective of large-scale coordination cues requires familiarity with the properties of mechanisms that underlie long-range pattern control. Non-neural bioelectricity is precisely such a set of mechanisms, and is increasingly implicated in cancer by molecular studies [181]. Most importantly, the known ability of bioelectric networks to process global information and implement networks with multiple causal layers (e.g.…”

Section: Cancer As a Disease Of Anatomical Homeostasismentioning

confidence: 99%

Cancer as a disorder of patterning information: computational and biophysical perspectives on the cancer problem

Moore

Walker

Levin

2017

Converg. Sci. Phys. Oncol.

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TOPICAL REVIEWCancer as a disorder of patterning information: computational and biophysical perspectives on the cancer problem IntroductionCancer is well-recognized not only as an extremely pernicious medical problem, but also as a group of phenomena deeply connected to the fundamental questions of evolution, multicellularity, pattern (disregulation, and the interplay between the genome and the environment [1,2]. Two fundamental paradigms currently divide the field. One is that cancer results from disorders of genetics: cancer cells are fundamentally broken due to genomic mutation or instability, and their clonal progeny form tumors and metastases. This view is sometimes called the SMT, somatic mutation theory [3][4][5]. A competing perspective is that of cancer as a circuit disease-a disorder of the complex biophysical, transcriptional, and epigenetic dynamics that regulate cellular state and the ability of cells to cooperate in vivo [6][7][8]. Under this view (sometimes called the tissue organization field theory or TOFT, [9,10]), cancer is akin to a traffic jam [11]-the problem is not a permanent discrete alteration within a founder cell and all of its clonal descendants, but an undesirable stable attractor in the complex network of controls that normally guides anatomical homeostasis [12].The relative merits of the two models have been discussed extensively [10,[13][14][15][16][17] AbstractThe current paradigm views cancer as arising clonally from a degradation of genetic information in single cells. A complementary perspective, originating at the dawn of modern developmental biology, is that cancer is the result of a system disorder of algorithms that normally orchestrate individual cell activities toward specific anatomical structures and away from tumorigenesis. A view of cancer as a disease of geometry focuses on the pathways that allow cells to cooperate to build and maintain large-scale anatomical patterning. Cancer may result when cells stop maintaining higher-order structures and reduce the boundary of their computational selves to a single-cell level, reverting to a unicellular lifestyle in which the rest of the organism is merely part of the environment at the expense of which all living things survive. While this view has been widely discussed, little progress has been made in providing a quantitative, mechanistic framework within which this perspective's specific and unique implications for treatment strategies can be tested and biomedically exploited. Here, we highlight two recent areas of progress which may facilitate much-needed progress on the cancer problem. First, we review the roles that endogenous bioelectrical networks, operating across many tissues in vivo, play as a medium of information processing in tumor suppression, progression, and reprogramming. Second, we provide a primer to the development of computational theory and tools for quantifying the information and causal control structures in cancer and other complex biological systems. Rigorous mathematical formalisms now exist to...

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“…Cancer development is characterized by a panel of hallmarks (including enhanced and autonomous proliferation, cell death resistance, immortality, angiogenesis, invasion and metastasis) in which ion channels mutations or alterations have been shown to be involved [101][102][103][104][105].…”

Section: Ne Differentiation In Cancer Progression-perspectives On Thementioning

confidence: 99%

Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation

Warnier¹,

Gackière²,

Roudbaraki³

et al. 2017

J Cell Signal

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Neuroendocrine cells release their secretion into the extracellular environment through calcium-dependent signalling pathways. These cells share common morphological and molecular features such as the expression of specific biomarkers, neurite outgrowth and dense core secretory granules. In order to elucidate the signalling pathways leading from undifferentiated to differentiated neuroendocrine cells, the role of voltage-dependent calcium channels, central actors in the excitation-secretion coupling, has been comprehensively investigated. T-type calcium channels appear to belong to the most important ion channel family involved in the neuroendocrine differentiation process. They could also participate in the development of neuroendocrine tumours.

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Ion Channels in Development and Cancer

Cited by 179 publications

References 94 publications

Planarian regeneration in space: Persistent anatomical, behavioral, and bacteriological changes induced by space travel

Planarian regeneration in space: Persistent anatomical, behavioral, and bacteriological changes induced by space travel

Cancer as a disorder of patterning information: computational and biophysical perspectives on the cancer problem

Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation

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