Ion Beam Nanopatterning of Biomaterial Surfaces

Abstract

Ion beam irradiation of solid surfaces may result in the self-organized formation of well-defined topographic nanopatterns. Depending on the irradiation conditions and the material properties, isotropic or anisotropic patterns of differently shaped features may be obtained. Most intriguingly, the periodicities of these patterns can be adjusted in the range between less than twenty and several hundred nanometers, which covers the dimensions of many cellular and extracellular features. However, even though ion beam nanopatterning has been studied for several decades and is nowadays widely employed in the fabrication of functional surfaces, it has found its way into the biomaterials field only recently. This review provides a brief overview of the basics of ion beam nanopatterning, emphasizes aspects of particular relevance for biomaterials applications, and summarizes a number of recent studies that investigated the effects of such nanopatterned surfaces on the adsorption of biomolecules and the response of adhering cells. Finally, promising future directions and potential translational challenges are identified.

Nanopattern Formation on Indium Phosphide Using Energetic Ions: An Overview with Various Ion Beam Parameters

“…X Gao et al (20) and C Teichert et al (21) used the hexagonal arrays of nanodots as templates for the formation of arrays of nanomagnets in high-density magnetic data storage on Cobalt Ferrite and GaSb nanodots respectively. Yu Yang et al (22) studied the rippled surfaces produced by ion bombardment as substrates for cell cultures with the substrate topography influencing cell adhesion and proliferation. A.…”

Surface nanopatterning by ion beam irradiation: compositional effects

“…It is worth noting that, due to the use of medium energy, it was possible to establish a correlation between this long wavelength corrugation and the local surface metal content [126]. In addition, the use of medium-energy ions in IBI with co-deposition set-ups produces taller nanostructures with higher aspect ratios, a fact that could be used for different applications [33,127].…”

“…In addition to this versatility, among the main attributes of IBI nanopatterning, we can also mention the large area that can be patterned, the short processing times and, finally, its cost-effective production. Thus, the technique has been applied in the last years in numerous fields such as magnetism [24][25][26][27][28], plasmonics [29], nanoelectronics [30], photovoltaics [31,32], biomaterials [33], and sensing [34][35][36][37].…”

Site‐Specific Emulation of Neuronal Synaptic Behavior in Au Nanoparticle‐Decorated Self‐Organized TiOx Surface

“…[30,32] As a result, anisotropic, electrical, [36] magnetic, [37,38] and optical properties [39,40] are realized. In addition, patterned surfaces are promising for cold cathode electron emission, [41,42] biology [43] as well as nano bio-electronic applications. [43] Moreover, if the implanted (metal) atoms occupy preferential sites on a patterned surface, the latter can exhibit tunable electrical properties at nanoscale.…”