Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants

Walsh, Verena; Brown, Jennifer Valeska Elli; McGuire, William

doi:10.1002/14651858.cd005253.pub3

Cited by 23 publications

(37 citation statements)

References 34 publications

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“…In a recent study in three major cities across the UK, researchers found no relation between iodine deficiency and low birth weight and preterm labour [40]. Walsh et al did not find any relation between maternal low iodine intake and perinatal mortality and neural development of the neonates of these mothers [41].…”

Section: Discussionmentioning

confidence: 96%

Maternal and neonatal outcomes and determinants of iodine deficiency in third trimester of pregnancy in an iodine sufficient area

Gargari

Fateh

Bakhshali-bakhtiari

et al. 2020

BMC Pregnancy Childbirth

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Background: Mild to moderate iodine deficiency in pregnant women may expose them to the increased risk of the development of goiter and thyroid disorder. There is a relationship between low maternal UIC (Urinary iodine concentration) in pregnancy and diminished placental weight and neonatal head circumference. The current study was an attempt to assess iodine nutritional status, its determinants and relationship with maternal and neonatal outcomes. Methods: In this population based cross-sectional study, which was conducted from April 2017 to September 2018, information was collected from 884 women of 20-45 years old who referred for periodic pregnancy visits. UIC was measured in random urine samples by applying a manual method which was based on the Sandell-Kolthoff technique. Information related to neonatal and maternal complications was collected from the individuals enrolled in the study through systematic follow-ups of the research team in each hospitals and the referral of trained midwives to the place of delivery and the retrieval of the case files.

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Section: Discussionmentioning

confidence: 96%

Maternal and neonatal outcomes and determinants of iodine deficiency in third trimester of pregnancy in an iodine sufficient area

Gargari

Fateh

Bakhshali-bakhtiari

et al. 2020

BMC Pregnancy Childbirth

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“…Five SRs (3,14,18,24,25) reported no impact of the interventions on the preterm infants. These supplements were inositol, iodine, fat, glutamine, and LCPUFA.…”

Section: No Impactmentioning

confidence: 99%

“…Walsh et al (14) and Amissah et al (18) concluded there was no impact of the iodine and fat supplementation owing to the outcome of no health improvement. Another 3 SRs (3, 24, 25) did not nd any evidence supporting their major outcome improvements though some positive results were observed.…”

Section: No Impactmentioning

confidence: 99%

“…In total, 160 quantitative primary studies were synthesised in the 17 SRs, all of which were RCTs or quasi-RCTs. Nine SRs (3,(13)(14)(15)(16)(17)(18)(19)(20) were published in the late 3 years (2018-2020), 5 SRs (21)(22)(23)(24)(25) were between year 2016 to year 2017 and only 3 SRs (26-28) were from year 2007, year 2010 and year 2014. , criteria 2 (duplicate study selection and data extraction), criteria 6 (characteristics of the included studies provided), criteria 7 (scienti c quality of the included studies assessed and documented), and criteria 8 (scienti c quality of the included studies used appropriately in formulating conclusions). The least met AMSTAR criteria was criteria 10 (likelihood of publication bias assessed) owing to the small number of the primary quantitative studies included in several SRs (3, 14, 16, 18-22, 27, 28).…”

Section: Characteristic and Quality Assessment Of Included Srsmentioning

confidence: 99%

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Effectiveness of Feeding Supplementation in Preterm Infants: An Overview of Systematic Reviews

Tao

Yang

et al. 2020

Preprint

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BackgroundPreterm infants have higher nutrition needs than term infants. The effectiveness of various feeding supplementation was assessed by the improvement of health outcomes in single specific systematic reviews (SRs). The aim of this review is to summarise these SRs to provide comprehensive evidence on the effectiveness of these interventions for preterm infants. MethodsA literature search was conducted in the PUBMED, EMBASE, Science Direct, Cochrane library, Web of Science, and Wiley online library. SR selection followed clear inclusion and exclusion criteria. Data extraction was performed by using the pre-designed tables and quality assessment was done by the AMSTAR tool. ResultsSeventeen SRs were included in the review. Fifteen kinds of feeding supplementation were reported in the SRs. The effectiveness of the interventions was defined as positive, having no impact, or inconclusive. Lactoferrin, probiotic, prebiotic, vitamin D, protein, and arginine were concluded to be positive; inositol, iodine, fat, glutamine, and long chain polyunsaturated fatty acid (LCPUFA) were concluded to have no impact; results for prebiotic (for prevention of hyperbilirubinaemia), carbohydrate, multi-nutrient, taurine, calcium, and phosphorus were inconclusive. All the SRs included were graded as being of high quality. ConclusionsSupplements with positive effects on health improvement were considerable to add to the feeding of preterm infants. More well-designed large RCTs are still needed to address the unsolved problems in the SRs concluded as having no impact or where the results were inconclusive.

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“…Of particular relevance are the detrimental effects of an insufficient maternal intake of iodine on development and maturation of the fetal brain, which represents a foremost preventable cause of mental defects [10]. Further adverse effects include abortion, stillbirth, impairment of cognitive functions, delayed growth and puberty, hypothyroidism, goiter, and infertility [11,12,13,14,15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Iodine Status in Schoolchildren and Pregnant Women of Lazio, a Central Region of Italy

et al. 2019

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The inhabitants of Lazio, similarly to those of other Italian regions, have been historically exposed to the detrimental effects of an inadequate intake of iodine. The latter is a micronutrient essential for the biosynthesis of thyroid hormones (TH). Iodine deficiency is responsible for a number of adverse effects on human health known as iodine deficiency disorders (IDD), the most common of which worldwide are goiter and hypothyroidism. In order to reduce IDD, a national salt iodination program was started in Italy in 2005. In this article we reviewed the available data regarding iodine intake in the Lazio population before and after the introduction of the national salt iodination program, in order to evaluate its efficacy and the eventual problem(s) limiting its success. On the whole, the information acquired indicates that, following the introduction of the program, the dietary iodine intake in the Lazio population is improved. There is, however, still much work ahead to ameliorate the iodine prophylaxis in this region. In fact, although a generally adequate iodine intake in school-age children has been observed, there are still areas where a mild iodine insufficiency is present. Moreover, two independent epidemiological surveys on pregnant women evidenced a low urinary iodine concentration with respect to the reference range conceived by the World Health Organization. These findings demonstrate the need for greater attention to the iodine prophylaxis by health care providers (i.e., obstetricians, gynecologists, pediatricians, etc.), and the implementation of effective advertising campaigns aimed at increasing the knowledge and awareness of the favorable effects of iodine supplementation on population health.

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Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants

Abstract: Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants.

Cited by 23 publications

References 34 publications

Maternal and neonatal outcomes and determinants of iodine deficiency in third trimester of pregnancy in an iodine sufficient area

Maternal and neonatal outcomes and determinants of iodine deficiency in third trimester of pregnancy in an iodine sufficient area

Effectiveness of Feeding Supplementation in Preterm Infants: An Overview of Systematic Reviews

Iodine Status in Schoolchildren and Pregnant Women of Lazio, a Central Region of Italy

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