Iodine(III)/AlX3-mediated electrophilic chlorination and bromination of arenes. Dual role of AlX3 (X = Cl, Br) for (PhIO)n depolymerization and as the halogen source

Iodine(iii) reagents for oxidative aromatic halogenation

“…In 2019 Solorio-Alvarado 57 reported another procedure for the aromatic chlorination and bromination of different arenes and heteroarenes 256 . The use of polymeric iodosylbenzene (PhIO) n in combination with aluminium trichloride or tribromide gives rise to chlorinated or brominated derivatives 257–273 (Scheme 24).…”

Recent Update on Transition Metal‐Free C(sp2)−H Bond Halogenation in (Hetero) Arenes

“…In this methodology, Alvarado et al . Depicted [55] a dual role of aluminum halide. The aluminum halide acted as halogen donor as well as it depolymerized the iodosylbenzene.…”

Indomethacin Synthesis, Historical Overview of Their Structural Modifications

“…This important contributor to science takes advantage of the knowledge from different strategies and concepts which involve the use of transition metals [7][8] as well as metal-free protocols. [9][10][11][12][13][14][15][16] Also important is the design and synthesis of different active compounds for addressing other affections such as pain [17] or inflammation. [18] In this context one of the most important (NSAID) non-steroidal anti-inflammatory drug with historical importance due to its effectivity is indomethacin.…”

“…One of the most important tools which has played a key role in the development of the aforementioned treatments is organic synthesis . This important contributor to science takes advantage of the knowledge from different strategies and concepts which involve the use of transition metals [7–8] as well as metal‐free protocols [9–16] . Also important is the design and synthesis of different active compounds for addressing other affections such as pain [17] or inflammation [18] .…”