Iodine: Biochemistry, Deficiency and Application in Clinical Nutrition

Jenzer, Helena

doi:10.14206/canad.j.clin.nutr.2017.01.01

Cited by 5 publications

(6 citation statements)

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“…Oxidized iodine derivatives are readily reactive and therefore relevant for both the iodination step and for side reactions of hormone biosynthesis. These reactive oxidation products include I -, I2, OI -,HOI, IO3 -, H5IO6, and H3IO6 2- (14). Rutin that added to chloramine-T was shaken using a 1000 rpm vortex shaker for 5 minutes to increase kinetic energy so that the collision event was more effective, and therefore, the I-oxidation reaction will be optimized.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Properties Of 131I-Rutin Under Acidic Labeling Condition As A Radiolabeled Compound For The Diagnosis Of Cancer

Sriyani

Shintia

Rosyidiah

et al. 2021

JSTNI

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Radiolabeled rutin (131I-rutin) has potential use in future diagnosis of cancer. The physicochemical characteristics of 131I-rutin are essential in regard to its distribution and accumulation in the body. Therefore, to ensure successful delivery of a labeled compound, it is necessary to evaluate its physicochemical properties. The labeling of 131I-rutin was accomplished using the oxidation method assisted by Chloramine-T under acidic conditions. Radiochemical purity value was measured by thin-layer chromatography (TLC-SG F254) using 100% methanol as the mobile phase. The electrical charge of 131I-rutin was determined by the paper electrophoresis. Moreover, the lipophilicity (P) was evaluated by the partition coefficient in the organic-water liquid. Plasma protein binding was determined in vitro by precipitation method using a 5% trichloroacetic acid (TCA) solution. The results showed that 131I-rutin has a neutral charge and a lipophilicity value (Log P) of 0.395 ± 0.203 (hydrophilic), and was bound to human blood plasma proteins with a percentage of 69.36% ± 1.88%.

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Section: Resultsmentioning

confidence: 99%

Physicochemical Properties Of 131I-Rutin Under Acidic Labeling Condition As A Radiolabeled Compound For The Diagnosis Of Cancer

Sriyani

Shintia

Rosyidiah

et al. 2021

JSTNI

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“…Iodine is a trace mineral essential in the biosynthesis of thyroid hormone and to regulate basal metabolic rate; thyroid hormones are required for normal neurodevelopment and growth especially in children [35,36]. Iodine in food exists in different chemical forms as iodide, inorganic iodine (I 2 ), iodate, as well as salts of potassium and sodium.…”

Section: Iodinementioning

confidence: 99%

“…Iodine deficiency disorder (IDD) has become a public health problem affecting people of all age groups especially children and breastfeeding mothers [38]. Under normal circumstance, the thyroid gland of a healthy individual is expected to encompass 70-80% of the total iodine in the body, which is about 15-20 mg while the body uses about 80 µg to produce thyroid hormones In the case of deficiency, the hypothalamus-pituitary-thyroid pathway becomes activated such that the volume of the thyroid gland increases until goiter becomes obvious, to be managed with surgery and replacement of thyroid hormone [35]. However in a patient with chronic iodine deficiency, iodine level in the thyroid can be as low as 1 mg leading to a spectrum of IDD which includes hypothyroidism, goiter, mental retardation and other growth abnormalities [39,40].…”

Section: Iodinementioning

confidence: 99%

“…As with most micronutrients, the daily requirements for iodine changes at different life stages, generally ranging between 90 µg to 290 µg. Daily iodine consumption below 50 µg may cause deficiency, while more than 350 µg may lead to excess iodine and above 600 µg can cause damage to the thyroid function [35] suggestive for the value of RDA levels in order to avoid deficiencies and potential toxicity.…”

Section: Iodinementioning

confidence: 99%

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Dietary Micronutrients from Zygote to Senility: Updated Review of Minerals’ Role and Orchestration in Human Nutrition throughout Life Cycle with Sex Differences

et al. 2021

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Micronutrients such as selenium, fluoride, zinc, iron, and manganese are minerals that are crucial for many body homeostatic processes supplied at low levels. The importance of these micronutrients starts early in the human life cycle and continues across its different stages. Several studies have emphasized the critical role of a well-balanced micronutrient intake. However, the majority of studies looked into or examined such issues in relation to a specific element or life stage, with the majority merely reporting the effect of either excess or deficiency. Herein, in this review, we will look in depth at the orchestration of the main element requirements across the human life cycle beginning from fertility and pregnancy, passing through infancy, childhood, adolescence, and reaching adulthood and senility, with insight on the interactions among them and underlying action mechanisms. Emphasis is given towards approaches to the role of the different minerals in the life cycle, associated symptoms for under- or overdoses, and typical management for each element, with future perspectives. The effect of sex is also discussed for each micronutrient for each life stage as literature suffice to highlight the different daily requirements and or effects.

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“…Iodine is an essential nutrient that is vital for regular metabolic activity. Despite the fact that other tissues contain 70% of the body's iodine, the thyroid gland is the most germane organ to the iodine effect [1]. Iodine is a microelement found in some foods naturally and is also offered as a nutritional supplement.…”

Section: Introductionmentioning

confidence: 99%

People's Knowledge and Practice of Salt Iodization, as Well as the Assessment of Iodine Content in Salt in the Cumilla Region of Bangladesh

Jahan

Hossain

Bhuiyan

et al. 2021

JAMPS

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Aim: To evaluate the household iodine content and knowledge, attitude, and behavior regarding salt iodization among the residents of Cumilla, Bangladesh. Subjects and Methods: We conducted a cross-sectional survey of 700 inhabitants in Cumilla's urban and rural areas to determine the iodine concentration of salt they consume. The participants were asked about what they know about iodine deficiency and salt iodization as well as how their salt was packaged and stored. Among them, 338 people provided a sample of salt to be tested of its iodine content by the titrimetric method. Results: 46.57% of people knew that iodization was the best way to prevent iodine deficiency while 35.14% considered salt iodization during purchasing. Most people stored salt in plastic boxes (89.7%) and closed containers (84.14%).Among all participants, only 37.14% of people were aware of the iodine requirement during pregnancy. In urban regions, the median iodine content was 36.76 ppm (OR=0.658, 95% CI, 0.469-0.925), while in rural areas, the median iodine content was 40.92 ppm (OR=1.188, 95% CI, 1.022-1.380). Iodine levels were less than 15 ppm (minimum limit) in 6.8% of samples and greater than 40 ppm (maximum limit) in 56.5%. Only 36.7% of the salt samples contained adequate iodine. Conclusion: An effective and consistent approach for controlling iodine concentration in distributed salt is required at Cumilla, Bangladesh.

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Iodine: Biochemistry, Deficiency and Application in Clinical Nutrition

Cited by 5 publications

References 0 publications

Physicochemical Properties Of 131I-Rutin Under Acidic Labeling Condition As A Radiolabeled Compound For The Diagnosis Of Cancer

Physicochemical Properties Of 131I-Rutin Under Acidic Labeling Condition As A Radiolabeled Compound For The Diagnosis Of Cancer

Dietary Micronutrients from Zygote to Senility: Updated Review of Minerals’ Role and Orchestration in Human Nutrition throughout Life Cycle with Sex Differences

People's Knowledge and Practice of Salt Iodization, as Well as the Assessment of Iodine Content in Salt in the Cumilla Region of Bangladesh

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