Iodine, a preventive and curative agent in the COVID-19 pandemic?

Verheesen, R.H.; Traksel, R. A. M.

doi:10.1016/j.mehy.2020.109860

Cited by 9 publications

(12 citation statements)

References 4 publications

(5 reference statements)

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“…However, in vitro studies showed increased cytokine synthesis in leukocytes treated with NaI or Lugol solution (iodine plus KI), and an epidemiological study showed a decreased immune response in iodine-deficient schoolchildren, despite normal thyroid hormone levels [74] . Interestingly, in Japan, a country known for its high iodine intake by the general population, relatively low mortality from COVID-19 has been observed despite having the eldest population in the world and having adopted relatively moderate lockdown measures [75] . However, both iodine deficiency and excess iodine are associated with an increased risk of thyroid disorders, and excessive iodine intake can precipitate hyper- or hypothyroidism and thyroid autoimmunity in some individuals [76] .…”

Section: Discussionmentioning

confidence: 99%

Association of trace element status in COVID-19 patients with disease severity

Bego

Meseldžić

Prnjavorac

et al. 2022

Journal of Trace Elements in Medicine and Biology

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Section: Discussionmentioning

confidence: 99%

Association of trace element status in COVID-19 patients with disease severity

Bego

Meseldžić

Prnjavorac

et al. 2022

Journal of Trace Elements in Medicine and Biology

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“…The study shows that patients treated with oral formulations of iodine show better prognosis than the placebo hence establishing its role in treating the disease. It has also been hypothesized that less number of deaths seen in Japan despite boosting a large number of old age population is because of the role of iodine in supporting innate immunity against viral pathogens since Japanese are famous for taking higher amounts of iodine [ 21 ] Since different preparations have different concentration-dependent efficacy and side effects, this will provide us to a better idea of optimal dosage with better efficacy and limited toxicity. The efficacy of iodine complex which will be reported in our trial will be compared to those of other topical alternates used to stop viral growth in nasopharynx as published in literature to establish the superiority, if any, of the iodine-based preparations.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of iodine complex in SARS-CoV-2-infected patients with mild to moderate symptoms: study protocol for a randomized controlled trial

Ashraf

Ashraf³

et al. 2022

Trials

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Background Coronavirus disease 2019 (COVID-19) caused by the novel coronavirus-infected millions globally. Despite a wide range of advised options for the treatment of COVID-19, a single strategy to tackle this pandemic remains elusive, thus far. That is why we are conducting a clinical trial to find out the efficacy of iodine complex to clear a viral load of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) along with a reduction in time taken to alleviate symptoms. Method The proposed study is a placebo-controlled, add-on, randomized trial using parallel group designs. This is a closed-label and adaptive with sample size reassessment, multi-centered design with a 1:1:1:1 allocation ratio and superiority framework. It will be conducted in Shaikh Zayed Post-Graduate Medical Complex, Ali Clinic, and Doctors Lounge, Lahore, Pakistan. This study will have three arms of mild to moderately symptomatic COVID-19 patients (50 patients in each) which will receive ionic-iodine polymer complex with 200 mg of elemental iodine: interventional arm A will have encapsulated, arm B will receive suspension syrup form, arm C will get throat spray, while arm X will be standard care with placebo. Data will be collected on self-constructed, close-ended questionnaires after obtaining written consent. Data will be analyzed using SAS version 9.4. COVID-19 patients will be monitored by RT-PCR and HRCT (high-resolution computed tomography) chest. In addition to these, the duration of the symptomatic phase and mortality benefits will be analyzed in both groups. Discussion The study is designed to measure the superior efficacy of the iodine complex as an add-on in treating COVID-19-positive patients with mild to moderate symptoms. This combination is hypothesized to improve various parameters like rapid viral load reduction, clinical and radiological improvement, lower mortality, and reduction in hospitalization. The trial will aid in devising a better strategy to cope with COVID-19 in a relatively inexpensive and accessible way. The implications are global, and this could prove itself to be the most manageable intervention against COVID-19 especially for patients from limited-resource countries with deprived socioeconomic status. Trial registration ClinicalTrials.govNCT04473261. Registered on July 16, 2020.

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“…Комісаренка та Інститутом гігієни праці НАМН України за підтримки Дитячого фонду ООН (ЮНІСЕФ), можна стверджувати, що дефіцит йоду є актуальним для всієї території України [5]. Наслідком ДЙ є зниження секреції тиреоїдних гормонів, що негативно впливає на імунну систему з розвитком соматичних та схильністю до частих респіраторних захворювань [6,7].…”

Section: вступunclassified

The effect of iodine deficiency on the course of recurrent respiratory infection in children living in the iodine deficient region

Sorokman

Макарова

2022

Mìžnarodnij endokrinologìčnij žurnal

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Background. The consequence of iodine deficiency is a decrease in the secretion of thyroid hormones, which adversely affects the immune system with the development of somatic and predisposition to frequent respiratory diseases. The purpose was to investigate the iodine supply of the body of children with recurrent respiratory infections (RRI) by studying the organification and inorganic fractions of iodine in the serum and excretion of iodine in the urine. Materials and methods. The study was conducted by simple sampling, taking into account the characteristics of the clinic course of respiratory disease. Clinical and laboratory and instrumental examination was performed in 60 children aged 3 to 11 years with a diagnosis of RRI. The concentration of iodine in urine, the level of inorganic and organification iodine in the blood were studied. Results. The clinical picture presented with the symptoms of intoxication, fever, and catarrhal symptoms typical of RRI. In children with severe RRI experienced a clear decrease in the iodine level to 57.34 μg/l (p < 0.05) and a decline in the blood content of total iodine and iodine organification by 31.12 and 39.11 % (p < 0.001), respectively. The concentration of inorganic iodine was significantly higher (p < 0.001). Such results indicate a “wrong” subcellular distribution of iodine into fractions in the inflammatory process caused by RRI. The children with detected iodine deficiency demonstrated a more severe course of RRI. There was a moderately negative relationship between the levels of organification and inorganic iodine (r = –0.515; p < 0.05) and a direct relationship between the blood concentrations of total and organification iodine (r = 0.899; p < 0.05). Conclusions. The course of RRI in patients with iodine deficiency is characterized by an increase in the level of inorganic iodine, a decrease in organification iodine and total iodine, the deepening of these changes correlates with the severity of the respiratory disease.

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Iodine, a preventive and curative agent in the COVID-19 pandemic?

Cited by 9 publications

References 4 publications

Association of trace element status in COVID-19 patients with disease severity

Association of trace element status in COVID-19 patients with disease severity

Clinical efficacy of iodine complex in SARS-CoV-2-infected patients with mild to moderate symptoms: study protocol for a randomized controlled trial

The effect of iodine deficiency on the course of recurrent respiratory infection in children living in the iodine deficient region

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